phosphorylase, Glycogen, Brain Proteine (GPBB)

Bezeichnung:
phosphorylase, Glycogen, Brain Proteine (GPBB)
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Synonyme:
GLYPHOA, GPBB, pygb
alle Proteine anzeigen Gen GeneID UniProt
GPBB 110078 Q8CI94
GPBB 5834 P11216
Ratte GPBB GPBB 25739 P53534

Weitere Synonyme anzeigen

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Weitere Proteine zu phosphorylase, Glycogen, Brain Interaktionspartnern

Human phosphorylase, Glycogen, Brain (GPBB) Interaktionspartner

  1. Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP (zeige BGLAP Proteine) through the formation of an intramolecular disulfide bond (Cys (zeige DNAJC5 Proteine)(318)-Cys (zeige DNAJC5 Proteine)(326)), known to act as a redox switch that precludes the allosteric activation of bGP (zeige BGLAP Proteine) by AMP (zeige APRT Proteine).

  2. disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP (zeige APRT Proteine) without affecting its activation by phosphorylation. This unique regulatory feature of bGP (zeige BGLAP Proteine) sheds new light on the isoform-specific regulation of glycogen (zeige GYS1 Proteine) phosphorylase and glycogen (zeige GYS1 Proteine) metabolism.

  3. the bGP (zeige BGLAP Proteine) structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP (zeige APRT Proteine).

  4. GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome.

  5. H-FABP (zeige FABP3 Proteine) and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome

  6. Brain-type glycogen (zeige GYS1 Proteine) phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor.

phosphorylase, Glycogen, Brain (GPBB) Protein Überblick

Protein Überblick

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Alternative names and synonyms associated with phosphorylase, Glycogen, Brain (GPBB)

  • phosphorylase, glycogen, muscle (pygm)
  • phosphorylase, glycogen; brain (PYGB)
  • phosphorylase, glycogen; brain (pygb)
  • brain glycogen phosphorylase (Pygb)
  • phosphorylase, glycogen; brain (Pygb)
  • GLYPHOA Protein
  • GPBB Protein
  • pygb Protein

Bezeichner auf Proteinebene für GPBB

brain glycogen phosphorylase , phosphorylase, glycogen; brain , glycogen phosphorylase, brain form , glycogen phosphorylase B

GENE ID SPEZIES
379862 Xenopus laevis
431680 Xenopus (Silurana) tropicalis
469908 Pan troglodytes
477003 Canis lupus familiaris
100173733 Pongo abelii
100380295 Salmo salar
110078 Mus musculus
5834 Homo sapiens
100037229 Xenopus laevis
421248 Gallus gallus
505560 Bos taurus
25739 Rattus norvegicus
403051 Danio rerio
554325 Ovis aries
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