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TrxR2 was overexpressed in non-small-cell lung cancer cells; our results suggest that TrxR2 acts as an oncogenic gene in the context of lung cancer progression
p53R2 (zeige RRM2B Proteine) acts as a positive regulator of TrxR2 activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage
TrxR2 deficiency-induced impaired proliferation and death of chondrocytes may be the pathological mechanism of the osteoarthropathy due to Selenium deficiency.
Evidence that the rs4485648 polymorphism of the TrxR2 gene might exert an independent effect on the development of Diabetic retinopathy.
Data suggest that TXNRD2 may represent a druggable target that could be deployed to reduce the development of fatal pulmonary metastases in patients with osteosarcoma (OS).
A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2, ATXN2 (zeige ATXN2 Proteine), and FOXC1 (zeige FOXC1 Proteine)
The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for Myocardial infarction in subjects with T2 Diabetes mellitus of Slovenian origin.
Data suggest TXNRD1 (zeige TXNRD1 Proteine) and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.
Absence of TXNRD2 in humans leads to glucocorticoid deficiency.
Single Nucleotide Polymorphisms in the genes GPX1 (zeige GPX1 Proteine) (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (zeige DIO2 Proteine) (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population.
Maintenance of mitochondrial ROS (zeige ROS1 Proteine) via Txnrd2 in endothelial cells is necessary for an intact vascular homeostasis and remodeling. Txnrd2 plays a vitally important role in balancing mitochondrial ROS (zeige ROS1 Proteine) production in the endothelium.
Suggest role for Txnrd2 in sustaining heart function during aging and suggest that Txnrd2 may be a modifier of heart failure.
Regulatory link was discovered between mitochondrial Txnrd and the JNK (zeige MAPK8 Proteine)-PHD2 (zeige EGLN1 Proteine)-Hif-1alpha (zeige HIF1A Proteine) axis, which highlights how the loss of Txnrd2 and the resulting altered mitochondrial redox balance impairs tumor growth as well as tumor-related angiogenesis.
The SirT1 (zeige SIRT1 Proteine) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (zeige SOD2 Proteine), catalase (zeige CAT Proteine), peroxiredoxins 3 and 5, thioredoxin 2 (zeige TXN2 Proteine), thioredoxin reductase 2, and uncoupling protein 2 (zeige UCP2 Proteine).
Data indicate that mammalian thioredoxin reductase (H-TrxR) reduces hypothiocyanous acid (HOSCN).
Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.
Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 (zeige TXN2 Proteine) system and that inhibition of TrxR2 results in increased H(2)O(2) emission.
Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial TrxR2 gene
Neither Trx2 (zeige TXN2 Proteine) nor TrxR2 gain of function modified the redox regulation of mitochondria-dependent apoptosis in cos-7 cells, Hela cells and Mouse Neuro2a cells.
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22.
, thioredoxin reductase
, selenoprotein Z
, thioredoxin reductase 2, mitochondrial
, thioredoxin reductase 3
, thioredoxin reductase TR3
, thioredoxin reductase beta
, TR beta