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In midgastrula embryos, Wnt5a (zeige WNT5A Proteine), Wnt11, and Wnt11b, but not Wnt3a (zeige WNT3A Proteine), acted across many cell diameters to orient Prickle3 (zeige PRICKLE3 Proteine)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
PAR-1 (zeige F2R Proteine) RNA rescues neural cell markers in embryos in which noncanonical Wnt (zeige WNT2 Proteine) signaling has been blocked. Novel roles for Wnt11R and PAR-1 (zeige F2R Proteine) were identified in neural cell specification. An unexpected connection was shown between morphogenesis and cell fate.
Xenopus Wnt11-R is expressed in neural tissue, the brachial arches, and the muscle layer of the heart.
Wnt11-R signaling regulates a calcium sensitive EMT (zeige ITK Proteine) event essential for dorsal fin development of Xenopus.
wnt11r is required in a non-cell-autonomous manner to control neural crest migration.
These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development.
Wnt4 (zeige WNT4 Proteine) and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation.
Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis.
under tensile stress, miR (zeige MLXIP Proteine)-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt (zeige WNT2 Proteine)/PCP (zeige BMP1 Proteine) pathway by directly targeting Wnt11
a mechanistic link between E-cadherin (zeige CDH1 Proteine) loss and subsequent control of Rho-driven anoikis resistance through p120 (zeige CTNND1 Proteine)- and Kaiso (zeige ZBTB33 Proteine)-dependent expression of Wnt11, is reported.
Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs (zeige NR2E3 Proteine) & found differential gene expression patterns for Wnt5a (zeige WNT5A Proteine) & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes.
Data show that Wnt5a (zeige WNT5A Proteine) and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation.
These results provide formal genetic proof that the majority of the endocardium and myocardium diverge by mid-gastrulation in the mouse, and suggest a tight spatial and temporal control of Wnt11 expression in the myocardial lineage.
Wnt5a (zeige WNT5A Proteine)/Wnt11 inhibit beta-catenin (zeige CTNNB1 Proteine) to promote SHF (zeige SHF Proteine) development through Caspase (zeige CASP3 Proteine)-dependent Akt (zeige AKT1 Proteine) degradation
Notch1 (zeige NOTCH1 Proteine)-induced WISP-1 (zeige WISP1 Proteine) expression appeared to be Wnt11-dependent, but Wnt1 (zeige WNT1 Proteine)-independent
Noncanonical Wnt (zeige WNT2 Proteine) signaling via Wnt5a (zeige WNT5A Proteine)/5b/11 may have role in the pathogenesis of aortic valve calcification.
TGF-beta1-induced sm-alpha-actin expression is mediated by WNT-11 via RhoA activation and subsequent actin cytoskeletal remodeling.
The positive rates of Wnt11 protein in normal esophageal epithelium tissue was 29.8% and in esophageal carcinomas tissue was 31.9%; there was no significant difference between the two groups
Data suggest that Wnt-11 may serve as a target for cervical cancer therapy.
The Wnt11 gene plays an important role in human mesenchymal stromal cells for enhancing the osteogenesis in an infectious environment.
Demonstrate immunohistochemical expression of Wnt11 and BCL2A1 (zeige BCL2A1 Proteine) in complete moles and normal villi.
Report high expression of Wnt11 in esophageal squamous cell carcinoma, which was significantly associated with AJCC stage.
High expression of Wnt-11 is associated with metastasis in cervical cancer.
differential Wnt11 immunoexpression in high-grade human serous ovarian cancer compared to low-grade human serous ovarian cancer could play important roles in serous ovarian cancer progression and may be modulated by Wnt5a (zeige WNT5A Proteine) expression levels.
data suggest an important role of Ror2 (zeige ROR2 Proteine) in mediating Wnt11 signaling and in regulating convergence and extension movements in zebrafish.
Swap70b and Def6a (zeige DEF6 Proteine) delineate Wnt11 and Wnt5b (zeige WNT5B Proteine) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
CTCF (zeige CTCF Proteine) acts upstream of wnt11 during zebrafish muscle development.
findings provide the first evidence that wnt11 itself is a downstream target of the Jnk (zeige MAPK8 Proteine) cascade in the non-canonical Wnt (zeige WNT2 Proteine) pathway
data reveal a previously unrecognized role for Wnt (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+) signalling in establishing an electrical gradient in the plane of the developing cardiac epithelium through modulation of ion-channel function
Wnt11 and Prickle1a are expressed in the dorsal forerunner cells and regulate Kupffer's vesicle morphogenesis.
three Wnt (zeige WNT2 Proteine) noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
wnt11 and Fz5 signaling promotes early eye development through the coordinated antagonism of signals that suppress retinal identity
Results suggest that Wnt11 controls tissue morphogenesis by modulating E-cadherin (zeige CDH1 Proteine)-mediated cell cohesion through Rab5c (zeige Rab5c Proteine), a novel mechanism of Wnt (zeige WNT2 Proteine) signaling in gastrulation.
with combined loss of Tbx16 and Wnt11 (Silberblick), coalesence is essentially absent. Possibly as a consequence, both the anterior movement of presumptive prechordal plate and organizer function, as assayed by eye-field separation, are disrupted.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.
, WNT11-related protein
, protein Wnt-11-related
, wingless-type MMTV integration site family, member 11
, protein Wnt-11b-2
, protein Wnt-11-like
, Wnt-11 protein
, wingless-related MMTV integration site 11