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Human TLN1 Protein expressed in Escherichia coli (E. coli) - ABIN1047720
Ben-Yosef, Francomano: Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. in Genomics 2000
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CD90 (Thy1 (zeige THY1 Proteine)) is a novel interactor of talin 1 in effector cells of autoimmune equine uveitis.
These findings suggested that Talin-1 protein was significantly upregulated in PCa (zeige FLVCR1 Proteine) tissues compared with that of BPH (zeige GLI3 Proteine) tissue and Talin-1 expression was an independent predictor for lymph node metastasis and biochemical recurrence of PCa (zeige FLVCR1 Proteine).
Serum talin-1 had 97.7% sensitivity.
Both TLN-1 and TLN-2 (zeige TLN2 Proteine) levels correlate with tumorigenicity in human HCC (zeige FAM126A Proteine), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
TLN1 significantly increases in refractory glioblastoma multiforme
Applying correlative imaging to link live cell and fixed immunofluorescence data on a single cell basis, we related per cell talin-1 levels to per cell measures quantitatively defining an array of cellular properties.
Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration.
Our data demonstrate that high expression of Talin-1 is associated with significantly poorer OS and poorer DMFS in NPC (zeige NPC1 Proteine) and depletion of Talin-1 expression inhibited NPC (zeige NPC1 Proteine) cell migration and invasion. Talin-1 may serve as novel prognostic biomarker in NPC (zeige NPC1 Proteine).
The activation of vinculin (zeige VCL Proteine) by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin (zeige VCL Proteine) association.
Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa (zeige ITGB3 Proteine) complex transmembrane/C-terminal domains and talin-1 in cell membrane environment during platelet activation.
Data suggest that anionic lipids (such as phosphatidylinositol phosphates) play crucial role in localization of peripheral membrane proteins (such as TLN1, auxilin-1, and PTEN [phosphatase and tensin homolog]). [review-like article]
FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (zeige FN1 Proteine) binding and adhesion.
Binding of vinculin (zeige VCL Proteine) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 or talin-2 (zeige TLN2 Proteine) modulates extracellular rigidity sensing.
Conformational activation of talin by PREL-1 (zeige APBB1IP Proteine) triggers integrin-mediated cell adhesion.
Direct methylation of talin, a key regulatory molecule in cell migration, by Ezh2 disrupted the binding of talin to F-actin and thereby promoted the turnover of adhesion structures.
reduction of talin-beta3 integrin (zeige ITGB3 Proteine) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding
As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM (zeige APBB1IP Proteine) binding and exposes the vinculin (zeige VCL Proteine) binding sites, which recruit vinculin (zeige VCL Proteine) to stabilize the complex.
Talin1 has unique expression versus talin 2 (zeige TLN2 Proteine) in the heart and modifies the hypertrophic response to pressure overload.
Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss.
suggest that Tln1-mediated Itgbeta1b plays a crucial role in maintaining cardiac sarcomeric Z-disks and endothelial/endocardial cell integrity in zebrafish
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
, Talin 1