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Human JUP ELISA Kit für Sandwich ELISA - ABIN417915
Ortega-Martínez, Gardeazabal, Erramuzpe, Sanchez-Diez, Cortés, García-Vázquez, Pérez-Yarza, Izu, Luís Díaz-Ramón, de la Fuente, Asumendi, Boyano: Vitronectin and dermcidin serum levels predict the metastatic progression of AJCC I-II early-stage melanoma. in International journal of cancer 2016
Knockdown of GATA6 (zeige GATA6 ELISA Kits) completely eliminated the effect of TCF1 (zeige HNF1A ELISA Kits), while forced expression of GATA6 (zeige GATA6 ELISA Kits) induced hESC differentiation
Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB (zeige CREB1 ELISA Kits)) protein (CBP (zeige CREBBP ELISA Kits))/beta-catenin (zeige CTNNB1 ELISA Kits) or gamma-catenin interaction.
Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF (zeige VEGFA ELISA Kits)-induced phosphorylation of VE-cadherin (zeige CDH5 ELISA Kits)
In JUP mutations are the frequent cause of Arrhythmogenic cardiomyopathy, isolated Brugada syndrome can appear due to reduced sodium channel activities.
investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles
Reduced plakoglobin staining in intercalated discs of heart tissue from human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization
Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.
Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology.
Expression of gamma-catenin in NSCLC cells resulted in reduced cell migration as determined by both scratch assays and trans-well cell migration assays.
Six variants of uncertain clinical significance in the PKP2 (zeige PKP2 ELISA Kits), JUP, and DSG2 (zeige DSG2 ELISA Kits) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (zeige TGFB3 ELISA Kits)/C-related pathogenic splice site mutations.
Mice with hepatic loss of the desmosomal protein gamma-Catenin are prone to cholestatic injury and chemical carcinogenesis.
EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase
In 2 knockin mouse models, endogenous Jup was engineered to express the Naxos-associated form of plakoglobin. Insufficiency of the truncated Naxos plakoglobin, rather than gain of function, accounted for cardiac disease manifestations.
plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (zeige LEF1 ELISA Kits)) differentially regulates the proximal promoters of Dsc2 (zeige DSC2 ELISA Kits) and Dsc3 (zeige DSC3 ELISA Kits)
our study reveals a function for gamma-catenin in the regulation of mESC differentiation and has implications for human cancers in which gamma-catenin is mutated and/or aberrantly expressed.
The data suggest novel function(s) for plakoglobin (PG) beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival.
decreased plakoglobin expression increases the invasive behavior of breast cancer cells; this is the first demonstration of a functional role for plakoglobin/gamma-catenin in the metastatic process
The cadherin-catenin signaling pathway was inactivated in spinal motor neurons to assess the significance of motor neuron position in motor circuit assembly; genetic inactivation of both beta- and gamma-catenin or N-cadherin (zeige CDH2 ELISA Kits), disrupts motor neuron positioning.
Lack of plakoglobin in epidermis leads to keratoderma.
Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.
plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development
knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted (zeige POMT2 ELISA Kits) tail
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\; however, not all transcripts have been fully described.
, junction plakoglobin
, Junction plakoglobin
, junction plakoglobin-like
, catenin (cadherin-associated protein), gamma 80kDa
, desmoplakin III
, gamma-catenin (plakoglobin)