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Human ITGB1 Protein expressed in Wheat germ - ABIN2752830
Ahn, Mohamedali, Anand, Cheruku, Birch, Sowmya, Cantor, Ranganathan, Inglis, Frank, Agrez, Nice, Baker: Characterization of the interaction between heterodimeric ?v?6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. in Journal of proteome research 2014
Findings demonstrate the neurotrophin (zeige BDNF Proteine), BDNF (zeige BDNF Proteine)-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (zeige MAG Proteine) .
Findings identify beta(1)-integrin as an important functional cargo during Ca(2+)-dependent rapid endocytosis stimulated by a diffusible guidance cue in Xenopus spinal neurons.
Itgb1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of Sharpin-deficient mice.
Taken together, acid-induced acute lung injury results in epithelial microvesicle shuttling of miR-17/221 that in turn modulates macrophage beta1 integrin recycling, promoting macrophage recruitment and ultimately contributing to lung inflammation.
Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (zeige CDH2 Proteine) pathway.
the transcription regulators YAP (zeige YAP1 Proteine) and TAZ (zeige TAZ Proteine) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.
Itgb1 is an essential niche molecule that maintains satellite cell (SC) homeostasis, and sustains the expansion and self-renewal of this stem cell pool during regeneration. We further show that Itgb1 cooperates with fibroblast growth factor 2 (Fgf2 (zeige FGF2 Proteine)), a potent growth factor for SCs (zeige TWIST1 Proteine), to synergistically activate their common downstream effectors, the mitogen-activated protein (MAP) kinase Erk (zeige MAPK1 Proteine) and protein kinase B (Akt (zeige AKT1 Proteine)).
this study shows that alpha4beta1 integrin mediates memory CD8 (zeige CD8A Proteine)+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.
results demonstrate that c-Cbl (zeige CBL Proteine) mediates the ubiquitination/degradation of integrin beta1, which leads to COMP (zeige COMP Proteine) deficiency-induced dilated cardiomyopathy.
Ptrh2 (zeige PTRH2 Proteine) levels were up-regulated in dystrophin (zeige DMD Proteine) deficient mdx (zeige DMD Proteine) muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx (zeige DMD Proteine) muscle and Duchenne muscular dystrophy (zeige DMD Proteine) patients. Similar to the a7 integrin, Ptrh2 (zeige PTRH2 Proteine) expression was decreased in laminin-a2 null gastrocnemius muscle
this study has identified a new role for Parvin (zeige PARVA Proteine) and alphaPix (zeige ARHGEF6 Proteine) downstream of the integrin-ILK (zeige ILK Proteine) signaling axis for mammary epithelial cell differentiation.
alpha5beta1 integrin can stimulate drug resistance in cancer cells via a mechanism based on inhibition of protein kinase (zeige CDK7 Proteine) Erk (zeige EPHB2 Proteine).
We measured the effect of recombinant Gal-3 (zeige LGALS3 Proteine) added exogenously on the lateral mobility of the alpha5b1 integrin on HeLa cells. Using single-particle tracking (SPT (zeige AGXT Proteine)) we detected increased lateral mobility of the integrin in the presence of Gal-3 (zeige LGALS3 Proteine), while its truncated C-terminal domain (Gal (zeige GAL Proteine)-3C) showed only minor reductions in lateral mobility.
By directly binding to the 3'UTRs of ITGA6 (zeige ITGA6 Proteine) and ITGB1, we found miR (zeige MLXIP Proteine)-30e-5p to suppress mainly the adhesion of ITGA6 (zeige ITGA6 Proteine) in CRC (zeige CALR Proteine) cells to laminin.Taken together, miR (zeige MLXIP Proteine)-30e-5p is a novel effector of P53 (zeige TP53 Proteine)-induced suppression of migration, invasion and metastasis
These data outline a new signaling mechanism by which KCa1.1 (zeige KCNMA1 Proteine) regulates beta1-integrin function and therefore invasiveness of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs).
sp(2) -Iminosugar alpha-glucosidase (zeige AGLU Proteine) inhibitor 1 (zeige PPP1R1A Proteine)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1 (zeige STIM1 Proteine), and FAK (zeige PTK2 Proteine) signaling pathways.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
The SALL4 (zeige SALL4 Proteine) - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.
membrane-proximal N-glycosylation is critical for intermolecular interactions between integrin beta1 and other cell membrane proteins, such as syndecan-4 (zeige SDC4 Proteine) and epidermal growth factor receptor (zeige EGFR Proteine). Moreover, alpha2,6-sialylation is required for beta1 activation
High ITGB1 expression is associated with lung metastasis in ovarian cancer.
the loss of MUC16 (zeige MUC16 Proteine) and E-cadherin (zeige CDH1 Proteine) expression resulted in the formation of more compact spheroids. In addition, our data describe an unusual link between E-cadherin (zeige CDH1 Proteine) expression and less compact spheroids. Our data also emphasize the role of MUC16 (zeige MUC16 Proteine) and b1 integrin in Epithelial ovarian cancer (EOC) spheroid formation.
beta1-integrin antigen-antibody interactions and the distribution of beta1-integrin protein on spermatogonial stem cell membrane were demonstrated using atomic force microscopy
The overall findings suggest that the secreted galectin-3 (zeige LGALS3 Proteine) stimulated by PGF (zeige PGF Proteine) plays a role in structural luteolysis by binding to beta 1 integrin.
Putative function of fibronectin (zeige FN1 Proteine) and its receptor (integrin alpha(5 (zeige ITGA5 Proteine))beta(1)) in male and female gametes during bovine fertilization in vitro.
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myosin light chain diphosphorylation.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
both the gpIb-VWF (zeige VWF Proteine) interaction and the integrin alpha(2 (zeige ITGA2 Proteine))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (zeige GSTA3 Proteine))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (zeige VWF Proteine) is bound
TRPV4 (zeige TRPV4 Proteine) channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
integrin beta 1
, integrin beta-1*
, integrin beta-1-B
, VLA-4 subunit beta
, fibronectin receptor subunit beta
, integrin beta-1
, beta OL
, beta oligodendroglia
, integrin VLA-4 subunit beta
, integrin beta 1 (fibronectin receptor beta)
, glycoprotein IIa
, integrin VLA-4 beta subunit
, very late activation protein, beta polypeptide
, integrin beta-1 subunit
, CSAT antigen
, JG22 antigen
, Fibronectin receptor subunit beta
, Integrin VLA-4 subunit beta
, Integrin subunit beta-1