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Rat (Rattus) NOX4 ELISA Kit für Sandwich ELISA - ABIN431602
El-Naga: Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4. in Chemico-biological interactions 2015
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Human NOX4 ELISA Kit für Sandwich ELISA - ABIN417447
Vital, Castro, Ittmann: Oxidative stress promotes benign prostatic hyperplasia. in The Prostate 2016
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Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (zeige ARCN1 ELISA Kits).
TIS21 (zeige BTG2 ELISA Kits) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (zeige ROS1 ELISA Kits)-ABI2-DRF (zeige MPO ELISA Kits) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (zeige NOX1 ELISA Kits)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (zeige TGFB1 ELISA Kits) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (zeige ROS1 ELISA Kits) and p38MAPK (zeige MAPK14 ELISA Kits). ROS (zeige ROS1 ELISA Kits) derived from NADPH oxidase (zeige NOX1 ELISA Kits) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (zeige BRD4 ELISA Kits) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (zeige TGFB1 ELISA Kits)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (zeige CYBA ELISA Kits) is possible and that the activity of Nox1 (zeige NOX1 ELISA Kits) and Nox4 but not Nox5 (zeige NOX5 ELISA Kits) exclusively depends on p22phox (zeige CYBA ELISA Kits).
These processes are mediated upstream by the reactive oxygen species (ROS (zeige ROS1 ELISA Kits))-producing enzyme Nox4.
data suggest that monocytic Nox4 is a central regulator of actin dynamics, and induction of Nox4 is the rate-limiting step in metabolic stress-induced monocyte priming and dysfunction associated with accelerated atherosclerosis and the progression of atherosclerotic plaques
findings demonstrate that manipulation of the host PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathway and Nox4 gene expression is a novel mechanism involved in T. gondii survival and proliferation
we used the Ang II (zeige AGT ELISA Kits) infused hph-1 (zeige EGLN2 ELISA Kits) mice to examine the roles of NOX isoforms in the development of AAA (zeige AAAS ELISA Kits). We generated double mutants of hph-1 (zeige EGLN2 ELISA Kits)-NOX1 (zeige NOX1 ELISA Kits), hph-1 (zeige EGLN2 ELISA Kits)-NOX2 (zeige CYBB ELISA Kits), hph-1 (zeige EGLN2 ELISA Kits)-p47phox, and hph-1 (zeige EGLN2 ELISA Kits)-NOX4
The major reactive oxygen species (ROS (zeige ROS1 ELISA Kits)) source in brain, NADPH oxidase (zeige NOX1 ELISA Kits) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (zeige NFE2L2 ELISA Kits), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (zeige ROS1 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits) signalling pathway.
Nox2 (zeige CYBB ELISA Kits)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.
FYN (zeige FYN ELISA Kits) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (zeige EDN1 ELISA Kits) production.
CYLD (zeige CYLD ELISA Kits) contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling.
Data suggests that ROS (zeige ROS1 ELISA Kits) produced during primitive endoderm differentiation is dependent in part on increased NOX1 (zeige NOX1 ELISA Kits) and NOX4 levels, which is under the control of GATA6 (zeige GATA6 ELISA Kits). Furthermore, these results suggest that the combined activity of multiple NOX proteins is necessary for the differentiation of F9 cells to primitive endoderm.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (zeige TGFB1 ELISA Kits)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (zeige NOX1 ELISA Kits) mediates oxidative stress and apoptosis caused by TNF-alpha (zeige TNF ELISA Kits) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (zeige NOX1 ELISA Kits)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (zeige HMOX2 ELISA Kits).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (zeige NOX1 ELISA Kits) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (zeige P4HB ELISA Kits) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4