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Prospective study demonstrated that AHRR (zeige CYP1A1 ELISA Kits) and F2RL3 methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer.
F2RL3 variants have the potential to markedly alter platelet PAR4 (zeige PAWR ELISA Kits) reactivity particularly after exposure to therapeutic PAR1 (zeige MARK2 ELISA Kits) antagonists.
these findings are the first to show that internalization of activated PAR4 (zeige PAWR ELISA Kits) is linked to proper ERK1/2 (zeige MAPK1/3 ELISA Kits) and Akt (zeige AKT1 ELISA Kits) activation.
an intracellular PAR4 C-terminal motif that regulates calcium signaling and beta-arrestin interactions, was identified.
the contribution of PAR1 (zeige MARK2 ELISA Kits) and PAR4 (zeige PAWR ELISA Kits) to thrombin (zeige F2 ELISA Kits)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.
Suppression of PAR4 (zeige PAWR ELISA Kits) expression has no significant effect on the proliferation of SW620 cells, but can inhibit the migration of the cells.
Both GPIbalpha (zeige GP1BA ELISA Kits) and PAR4 (zeige PAWR ELISA Kits) are required for thrombin (zeige F2 ELISA Kits)-induced reactive oxygen species formation in human platelets.
Bladder PAR (zeige JTB ELISA Kits) activation elicits urothelial MIF (zeige AMH ELISA Kits) release and urothelial MIF (zeige AMH ELISA Kits) receptor signaling at least partly through CXCR4 (zeige CXCR4 ELISA Kits) to result in abdominal hypersensitivity without overt bladder inflammation
protease-activated receptor 4 and Trefoil factor 2 (zeige TFF2 ELISA Kits) are expressed in human colorectal cancer
The PAR4 (zeige PAWR ELISA Kits) expression and activation via intracellular signaling pathways and the role of PAR4 (zeige PAWR ELISA Kits) signaling pathways in the development and maintenance of pain.
beige (zeige LYST ELISA Kits) adipocyte renaissance was governed by liver kinase b1 (zeige STK11 ELISA Kits) and histone deacetylase 4 (zeige HDAC5 ELISA Kits) in white adipocytes.
miR-17-92-dependent tuning of LKB1 (zeige STK11 ELISA Kits) levels regulates both the metabolic potential of Myc (zeige MYC ELISA Kits)+ lymphomas and tumor growth in vivo.
Findings indicate that the energy-sensing LKB1 (zeige STK11 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits) pathway regulates IGF1 (zeige IGF1 ELISA Kits) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (zeige IGF1R ELISA Kits)-PKB (zeige AKT2 ELISA Kits) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (zeige STK11 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits) mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
this study identified the molecular mechanism of increased angiogenesis and tumor growth with LKB1 (zeige STK11 ELISA Kits) deficiency
These results suggest that although physiologic LKB1 (zeige STK11 ELISA Kits) expression exerts a potent pro-survival effect in lymphocytes, LKB1 (zeige STK11 ELISA Kits) inactivation nonetheless facilitates transformation of B, but not T, lymphocytes.
These results suggest that the LKB1 (zeige STK11 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits)-FoxO1 (zeige FOXO1 ELISA Kits) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
Lkb1 (zeige STK11 ELISA Kits) activates the Notch (zeige NOTCH1 ELISA Kits) signaling pathway, which subsequently increases Pax7 (zeige PAX7 ELISA Kits) expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 (zeige STK11 ELISA Kits) regulates Notch (zeige NOTCH1 ELISA Kits) activation through AMPK (zeige PRKAA1 ELISA Kits)-mTOR (zeige FRAP1 ELISA Kits) pathway in myoblasts.
mitochondrial dysfunction triggers LKB1 (zeige STK11 ELISA Kits)-mediated AMPK (zeige PRKAA1 ELISA Kits) activation, which stimulates Sirt2 (zeige SIRT2 ELISA Kits) phosphorylation, leading to activation of mTOR (zeige FRAP1 ELISA Kits)-RAPTOR (zeige RPTOR ELISA Kits) and Glut1 (zeige SLC2A1 ELISA Kits)-mediated glucose uptake.
these data demonstrated that LKB1 (zeige STK11 ELISA Kits)/AMPK (zeige PRKAA1 ELISA Kits) signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1 (zeige STK11 ELISA Kits)/AMPK (zeige PRKAA1 ELISA Kits) signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
proteinase-activated receptor 4
, coagulation factor II (thrombin) receptor-like 3
, coagulation factor II (thrombin)
, protease-activated receptor-4
, thrombin receptor-like 3
, coagulation factor II receptor-like 3
, protease-activated receptor 4
, LKB1 short isoform
, liver kinase B1 homolog
, serine/threonine-protein kinase 11
, serine/threonine-protein kinase LKB1
, serine/threonine-protein kinase STK11