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In the TMD (zeige TTN ELISA Kits) discovery cohort, sex-stratified analysis identified 2 additional genome-wide significant loci in females. One lying upstream of the relaxin/insulin-like family peptide receptor 2 ( RXP2) (chromosome 13, rs60249166,[OR] = 0.65, P = 3.6 x 10(-8)) was replicated among females in the meta-analysis (1-tailed P = 0.052). The other (chromosome 17, rs1531554, OR = 0.68, P = 2.9 x 10(-8)) was replicated among f
Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.
Findings suggest a novel and gender-specific role for INSL3 (zeige INSL3 ELISA Kits) and cognate receptor RXFP2 signaling in ocular surface homeostasis.
These results provide new mechanistic insights into the binding and activation events of RXFP1 (zeige RXFP1 ELISA Kits) and RXFP2 by their native hormone ligands.
Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin (zeige 0 ELISA Kits)
relaxin-2 (zeige RLN1 ELISA Kits) and its receptors RXFP1 (zeige RXFP1 ELISA Kits) and RXFP2 are expressed in GSV and their expression is significantly decreased in varicose GSV
haplotype analysis of the RXFP2 gene in T222P carriers and their parents showed that this variant is linked to the previously inferred C-C-G-A-13 haplotype and consequently provides further support to the 'founder effect' hypothesis
higher expression of LGR8 may facilitate tumor invasiveness in the early clinical stage of hepatocellular carcinoma.
Data show that synthetic parallel dimer of the B-chain of INSL3 (zeige INSL3 ELISA Kits) is a potent inhibitor of the native peptide's binding to its receptor, RXFP2.
the only clinical consequence of alterations of the INSL3 (zeige INSL3 ELISA Kits)-LGR8 system seems to be failure of the testis to normally descend in the scrotum during embryonic development, without affecting the spermatogenic and endocrine components of the testis itself
Results suggest that DES (zeige DES ELISA Kits) causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells.
The results displayed that INSL3 (zeige INSL3 ELISA Kits) changed RXFP2 expression in mouse gubernaculum testis cells in vitro
data suggest a novel role for Rln (zeige RLN1 ELISA Kits) in craniofacial skeletal development and metabolism through Rxfp2
Rxfp1 (zeige RXFP1 ELISA Kits), Rxfp2, and Nr3c1 (zeige NR3C1 ELISA Kits) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
Spermatogonial stem cells undergo drastic depletion in the cryptorchid testes of RXFP2 deficient mice.
Data suggest that Insl3 (zeige INSL3 ELISA Kits)/Rxfp2 (insulin-like peptide 3 (zeige INSL3 ELISA Kits)/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility.
Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis.
A deficiency for Rxfp2 on Cav1 (zeige CAV1 ELISA Kits)-deficient background led to more than a 2-fold increase in the incidence of uterine cysts.
A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3 (zeige INSL3 ELISA Kits), resulting in failure of the transabdominal phase of testicular descent.
RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent.
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
G protein coupled receptor affecting testicular descent
, G-protein coupled receptor 106
, G-protein coupled receptor affecting testicular descent
, leucine-rich repeat-containing G protein-coupled receptor 8
, leucine-rich repeat-containing G-protein coupled receptor 8
, relaxin family peptide receptor 2
, relaxin receptor 2
, G protein-coupled receptor 106
, INSL3 receptor