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Both FMRP deficiency in Fmr1(I304N) mice and Fmr1 knockdown impeded the axonal delivery of miR-181d, Map1b, and Calm1 and reduced the protein levels of MAP1B and calmodulin in axons.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
Data suggest that Cys3602 in RyR2 (ryanodine receptor 2) plays important role in activation/termination of Ca2+ release, but it is not essential for calmodulin regulation of RyR2.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.
Ca(2+) binding to calmodulin induces major conformational changes in both IQ motifs and the post-IQ domain and increases flexibility of the myosin-1c tail.
Using mass spectrometry this study identified calmodulin as a calcium-dependent GluN2A (zeige GRIN2A Proteine) binding partner.
new insights into the role of BTK (zeige BTK Proteine), an important target for autoimmune diseases, in B cell activation (zeige BLNK Proteine)
The relationships between the interaction of alphaCaMKII with CaM and the conformational change of alphaCaMKII, were investigated.
the conformational changes of calmodulin (zeige KRIT1 Proteine) upon Ca(2 (zeige CA2 Proteine)+) and mastoparan binding
MLCK and calmodulin (CaM) co-purify with unphosphorylated SMM from chicken gizzard, suggesting that they are tightly bound.
Human arrhythmogenic calmodulin mutations impede the activation of SK2 channels in human embryonic kidney 293 cells.
The results demonstrated CaM binding to DR5 (zeige TNFRSF10B Proteine)-mediated DISC in a calcium dependent manner and may identify CaM as a key regulator of DR5 (zeige TNFRSF10B Proteine)-mediated DISC formation for apoptosis in breast cancer.
Insights from structural proteomics can be used to generate CaM-insensitive mutants of CaM targets for functional studies in vitro or ideally in vivo.
The unique C terminus of the calcineurin isoform CNAbeta1 confers non-canonical regulation of enzyme activity by Ca(2+) and calmodulin
The main functional derangement in CALM1-F142L was prolonged repolarization with altered rate-dependency and sensitivity to beta-adrenergic stimulation.
These results reveal that mTOR is a new type of calmodulin-dependent kinase, and TRPML1, lysosomal calcium and calmodulin play essential regulatory roles in the mTORC1 signaling pathway.
The structural basis for the recognition of EEF2K by calmodulin has been presented.
irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU (zeige CALU Proteine), and RCN1 (zeige RCAN1 Proteine), suggesting important roles for these mediators in promoting irradiated tumor cell survival during hypoxia
Calcium modulates calmodulin-ACTN1 (zeige ACTN1 Proteine) interaction with and agonist-dependent internalization of the adenosine A2A receptor (zeige ADORA2A Proteine).
Data suggest that GRB10 (zeige GRB10 Proteine) and GRB14 (zeige GRB14 Proteine) are both Ca2 (zeige CA2 Proteine)+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 (zeige GRB10 Proteine) and GRB14 (zeige GRB14 Proteine), as compared to a single one present in GRB7 (zeige GRB7 Proteine). (GRB10 (zeige GRB10 Proteine) = growth factor receptor-bound protein 10 (zeige GRB10 Proteine); GRB14 (zeige GRB14 Proteine) = growth factor receptor-bound protein 14 (zeige GRB14 Proteine); CaM = calmodulin; GRB7 (zeige GRB7 Proteine) = growth factor receptor-bound protein 7 (zeige GRB7 Proteine))
analysis of CaM docked to a functioning KCNQ K(+) channel (KCNQ2 and KCNQ3) [KCNQ2, KCNQ3]
Asp-CaM complex has a critical role in centrosome-pole cohesion and centrosome inheritance in neural stem cells
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
characterized the interdomain motions in the calcium-bound state of calmodulin (Ca(2+)-CaM) using NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations
Regulatory implications of a novel mode of interaction of calmodulin with a double IQ-motif target sequence from murine dilute myosin V (zeige MYO5A Proteine).
null behavioral phenotype originates in the nervous system and involves a calmodulin function that requires calcium binding to all four sites of the protein
the direct interaction of melatonin with intact calcium-saturated CaM is calcium-dependent; Molecular dynamics simulations follow the dynamics of melatonin in the binding pocket of CaM
potential functional role for calmodulin in regulation of the glycolytic pathway
A mutation to the gene encoding calmodulin deregulates muscle contraction.
Drosophila CaM is able to fully activate inducible nitric oxide synthase (iNOS (zeige NOS2 Proteine)); moreover, iNOS (zeige NOS2 Proteine) activation by CaM, like neuronal NOS (zeige NOS1 Proteine), is not dependent on Ca2 (zeige CA2 Proteine)+ being bound to all four Ca2 (zeige CA2 Proteine)+-binding sites, but has specific and distinct requirements.
Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2 (zeige CA2 Proteine)+)-stimulating G protein-coupled receptor (zeige GPBAR1 Proteine), which could prevent cell damage due to extra Ca(2 (zeige CA2 Proteine)+) influx.
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calmodulin 1 (phosphorylase kinase, delta)
, calmodulin 2
, calmodulin 3
, calmodulin 1 (phosphorylase kinase, delta)
, phosphorylase kinase subunit delta
, phosphorylase kinase, delta subunit
, prepro-calmodulin 1
, Calmodulin-2 A
, Calmodulin-2 B
, CG8472 gene product from transcript CG8472-RC
, CaM Gamma 2