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anti-Human Thrombospondin 1 Antikörper:
anti-Mouse (Murine) Thrombospondin 1 Antikörper:
anti-Rat (Rattus) Thrombospondin 1 Antikörper:
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Cow (Bovine) Monoclonal Thrombospondin 1 Primary Antibody für BP, ICC - ABIN151527
Cupi, Sarra, De Nitto, Franzè, Marafini, Monteleone, Del Vecchio Blanco, Paoluzi, Di Fusco, Gentileschi, Ortenzi, Colantoni, Pallone, Monteleone: Defective expression of scavenger receptors in celiac disease mucosa. in PLoS ONE 2014
Show all 4 Pubmed References
Human Polyclonal Thrombospondin 1 Primary Antibody für ELISA, WB - ABIN4359279
Pan, Chang, Chuang, Hung: The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells. in Experimental biology and medicine (Maywood, N.J.) 2008
These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
High plasma levels of TSP-1 are associated with increased pulmonary arterial pressure, increased pulmonary vascular resistance and decreased survival pulmonary hypertension.
Our data suggest that the molecular network including TSP-1, TGF-beta1 (zeige TGFB1 Antikörper), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
Genetic variants of THBS1 were significantly more frequent in patients affected by idiopathic/genetic generalized epilepsies than in non-epileptic controls.
In pulmonary hypertension TSP1-CD47 (zeige CD47 Antikörper) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
High THBS1 expression is associated with primary effusion lymphoma.
Results show that the presence of OPN (zeige SPP1 Antikörper) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.
KLK4 (zeige KLK4 Antikörper) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.
Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)
cultured astrocytes isolated from an Fmr1 (zeige FMR1 Antikörper) knockout (Fmr1 (zeige FMR1 Antikörper) KO) mouse model of Fragile X (zeige FMR1 Antikörper) syndrome displayed a significant decrease in TSP-1 (zeige GZMA Antikörper) protein expression compared to the wildtype (WT) astrocytes.
In pulmonary hypertension TSP1 (zeige GZMA Antikörper)-CD47 (zeige CD47 Antikörper) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
HIF-1alpha (zeige HIF1A Antikörper) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (zeige MLXIP Antikörper)-21 via inhibiting a novel target gene TSP-1 (zeige GZMA Antikörper). Both of them may contribute to the protective effect of HIF-1alpha (zeige HIF1A Antikörper) on renal I/R injury.
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige GZMA Antikörper)/CD47 (zeige CD47 Antikörper) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
TSP-1 (zeige GZMA Antikörper) deficiency promotes maladaptive remodelling of the ECM (zeige MMRN1 Antikörper) leading to accelerated abdominal aortic aneurysms progression.
TSP-1 (zeige GZMA Antikörper) suppressed insulin (zeige INS Antikörper) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (zeige MAPK8 Antikörper), p38 (zeige CRK Antikörper), and IKK (zeige CHUK Antikörper).
Three transcription factors were overexpressed and eleven underexpressed in TSP1 (zeige GZMA Antikörper)(-/-) compared to WT LGs (zeige LGSN Antikörper).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
demonstrate that HIF-2alpha (zeige EPAS1 Antikörper) is clearly implicated in the TSP1 (zeige GZMA Antikörper) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (zeige THBS2 Antikörper) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (zeige THBS2 Antikörper), up-regulates expression of FGF2 (fibroblast growth factor 2 (zeige FGF2 Antikörper)).
Thrombospondin has a role in inducing RhoA (zeige RHOA Antikörper) inactivation through FAK (zeige PTK2 Antikörper)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (zeige INS Antikörper)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (zeige CD44 Antikörper) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (zeige KDM5D Antikörper)).
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (zeige IGF1 Antikörper) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (zeige TGFB1 Antikörper) expression.
ELL (zeige ELL Antikörper) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, thrombospondin 1