anti-MMP14 (MMP14) Antikörper

Bezeichnung:
anti-Matrix Metallopeptidase 14 (Membrane-inserted) Antikörper (MMP14)
Auf www.antikoerper-online.de finden Sie aktuell 263 Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MMP14 Kits (28) und MMP14 Proteine (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 332 MMP14 Produkte verfügbar.
Synonyme:
AI325305, MMP-14, MMP-X1, MMP1, MT-MMP, MT-MMP-1, MT-MMP 1, Mt1-mmp, MT1MMP, MTMMP1, sabe

Meistgesuchte Reaktivitäten zu anti-MMP14 (MMP14) Antikörper

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anti-Human MMP14 Antikörper:

anti-Mouse (Murine) MMP14 Antikörper:

anti-Rat (Rattus) MMP14 Antikörper:

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Am meisten referenzierte anti-MMP14 Antikörper

  1. Human Polyclonal MMP14 Primary Antibody für IHC (p), WB - ABIN3044302 : Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet. in Biochemical and biophysical research communications 2012 (PubMed)
    Zeige alle 6 Referenzen für 3044302

  2. Human Polyclonal MMP14 Primary Antibody für WB - ABIN3043408 : Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice. in High altitude medicine & biology 2013 (PubMed)
    Zeige alle 6 Referenzen für 3043408

  3. Human Polyclonal MMP14 Primary Antibody für FACS, IHC (p) - ABIN390138 : Will, Hinzmann: cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. in European journal of biochemistry / FEBS 1995 (PubMed)
    Zeige alle 4 Referenzen für 390138

  4. Human Monoclonal MMP14 Primary Antibody für FACS, IHC - ABIN4899219 : Mierke, Bretz, Altevogt: Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion. in The Journal of biological chemistry 2011 (PubMed)
    Zeige alle 4 Referenzen für 4899219

  5. Human Polyclonal MMP14 Primary Antibody für ELISA, WB - ABIN1536142 : Sato, Takino, Okada, Cao, Shinagawa, Yamamoto, Seiki: A matrix metalloproteinase expressed on the surface of invasive tumour cells. in Nature 1994 (PubMed)
    Zeige alle 2 Referenzen für 1536142

  6. Human Polyclonal MMP14 Primary Antibody für EIA, IHC (p) - ABIN358687 : Takino, Sato, Yamamoto, Seiki: Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain. in Gene 1995 (PubMed)
    Zeige alle 2 Referenzen für 358687

  7. Human Monoclonal MMP14 Primary Antibody für FACS - ABIN4895756 : Loskutov, Kozyulina, Kozyreva, Ice, Jones, Roston, Smolkin, Ivanov, Wysolmerski, Pugacheva: NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. in Oncogene 2015 (PubMed)

  8. Human Polyclonal MMP14 Primary Antibody für WB - ABIN1881546 : Sakr, Takino, Domoto, Nakano, Wong, Sasaki, Nakanuma, Sato: GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. in Cancer science 2010 (PubMed)

  9. Human Monoclonal MMP14 Primary Antibody für FACS - ABIN4895758 : Sathyamoorthy, Tezera, Walker, Brilha, Saraiva, Mauri, Wilkinson, Friedland, Elkington: Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis. in Journal of immunology (Baltimore, Md. : 1950) 2015 (PubMed)

Weitere Antikörper gegen MMP14 Interaktionspartner

Human Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. Data suggest that phosphorylation of Thr567 in cytoplasmic tail of MT1-MMP (MMP14) influences behavior of both individual ovarian cancer cells and multicellular aggregates; tumor cells expressing MT1-MMP-T567E phosphomimetic mutant exhibit enhanced cell migration and enhanced cell adhesion to peritoneum and other biological surfaces.

  2. MMP-14 Is a novel substrate for matriptase (zeige ST14 Antikörper), which regulates the levels of MMP-14 on the cell surface. High levels of matriptase (zeige ST14 Antikörper) in alpha-1 antitrypsin (zeige SERPINA1 Antikörper) deficiency may contribute to increased extracellular matrix degradation by alveolar macrophages both directly and through MMP-14 activation.

  3. High expression of MMP14 and CDK7 (zeige CDK7 Antikörper) was independent prognostic factors for overall survival in patients with gastric cancer.

  4. only collagen-IV (zeige COL4 Antikörper) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (zeige SRC Antikörper) phosphorylation, p190RhoGAP (zeige GRLF1 Antikörper)-B (also known as ARHGAP5 (zeige ARHGAP5 Antikörper)) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites.

  5. This study demonstrates that excessive ECM (zeige MMRN1 Antikörper) degradation mediated by high levels of MT1-MMP is not associated with cell migration and tumourigenesis, while low levels of MT1-MMP promote invasion and vascularization in vivo.

  6. DDR2 (zeige DDR2 Antikörper) mediates collagen-induced activation of MT1-MMP in human fibroblasts

  7. results suggest that the cytoplasmic domain regulates MT1-MMP function in a manner required for cell survival, but is dispensable for cell migration

  8. MMP14 plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF (zeige HBEGF Antikörper), which accelerates lung tumor progression.

  9. We conclude that ADAM12 (zeige ADAM12 Antikörper) and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas, which qualifies these proteins in diagnosis and therapy.

  10. The results suggest a regulatory role of miRNA-410 in modulating levels of MMP-14 in endometrial cancer

Mouse (Murine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 and MMP15 (zeige MMP15 Antikörper) in regulating mammary gland adipocyte differentiation. Whereas MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 (zeige MMP15 Antikörper) differentially controls the formation of thermogenic brown fat.

  2. The authors identified the membrane-tethered matrix metalloprotease (zeige ADAMTS7 PLURAL_@27060@) MT1-MMP as a prominent host-extracellular matrix-remodeling collagenase in influenza infection.

  3. MMP-14 expression in fibroblasts plays a crucial role in collagen remodeling in adult skin and largely contributes to dermal homeostasis underlying its pathogenic role in fibrotic skin disease in a mouse model

  4. MT1-MMP directly cleaves LYVE-1 (zeige LYVE1 Antikörper) on lymphatic endothelial cells to inhibit LYVE-1 (zeige LYVE1 Antikörper)-mediated lymphangiogenic responses and restrains the production of VEGF-C (zeige VEGFC Antikörper).

  5. The authors propose a model for cell-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular bridge tethering collagen fibrils to the plasma membrane of fibripositors.

  6. We demonstrate that MMP-14-mediated signaling in fetal hepatic progenitor cells promotes biliary luminal formation around the portal vein and negatively controls the maturation of hepatocytes.

  7. Results show a reciprocal association between levels of heparanase (zeige HPSE Antikörper) and MMP14, a membrane-bound MMP, shedding light on how branching occurs within developing mammary glands.

  8. MT1-MMP proteolytic activity is required for maintaining cell integrity, loss of MT1-MMP causes cell senescence and nuclear defects.

  9. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 (zeige TIMP1 Antikörper) and TIMP2 (zeige TIMP2 Antikörper) correlates negatively with the invasive potential of cells.

  10. Angiotensin II suppresses RECK (zeige RECK Antikörper), but induces matrix metalloproteinases both in vivo and in vitro.

Cow (Bovine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. results suggest that ET-1 (zeige EDN1 Antikörper)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Antikörper)-PKCalpha (zeige PKCa Antikörper)-p(38)MAPK (zeige MAPK1 Antikörper) and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Antikörper) expression in the cells

  2. Data indicate the involvement of PKC-alpha (zeige PKCa Antikörper) in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP-dependent and -independent pathway.

  3. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (zeige MMP2 Antikörper); MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

  4. MMP-14, MMP-2 (zeige MMP2 Antikörper) and TIMP-2 (zeige TIMP2 Antikörper) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  5. Results describe distinct changes in expression of MMP2 (zeige MMP2 Antikörper), MMP14, and the metallopeptidase (zeige ECEL1 Antikörper) inhibitor TIMP2 (zeige TIMP2 Antikörper) between different phases of the estrous cycle indicating an endocrine regulation.

  6. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 (zeige MMP2 Antikörper) and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.

  7. MT1-MMP seems to act by inducing tissue remodeling in cartilage

  8. sphingosine 1-phosphate is the predominant serum factor essential for MT1-MMP-dependent migration and morphogenic differentiation of vascular endothelial cells

Rabbit Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. MT1-MMP plays a crucial role in RAGE (zeige AGER Antikörper)-activated NADPH oxidase (zeige NOX1 Antikörper)-dependent signaling pathways.

  2. MMP-1 (zeige MMP1 Antikörper) was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation.

Pig (Porcine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion.

  2. A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling.

  3. PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 (zeige MMP2 Antikörper) as critical events in neointimal hyperplasia after vascular injury.

  4. Induction of endogenous MMP-14 gene and coexpression of SAF-1 (zeige MAZ Antikörper) & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 (zeige MAZ Antikörper) as a key regulator of MMP-14 gene induction in macrophage cells.

  5. In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion.

MMP14 Antigen-Profil

Beschreibung des Gens

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Alternative names and synonyms associated with MMP14

  • matrix metallopeptidase 14 (membrane-inserted) (mmp14) Antikörper
  • matrix metallopeptidase 14 (membrane-inserted) (MMP14) Antikörper
  • matrix metallopeptidase 14 (membrane-inserted) (Mmp14) Antikörper
  • AI325305 Antikörper
  • MMP-14 Antikörper
  • MMP-X1 Antikörper
  • MMP1 Antikörper
  • MT-MMP Antikörper
  • MT-MMP-1 Antikörper
  • MT-MMP 1 Antikörper
  • Mt1-mmp Antikörper
  • MT1MMP Antikörper
  • MTMMP1 Antikörper
  • sabe Antikörper

Bezeichner auf Proteinebene für MMP14

matric metalloproteinase 14 , matrix metalloproteinase-14 , membrane type 1 metalloprotease , membrane-type-1 matrix metalloproteinase , MMP-14 , MMP-X1 , MT-MMP 1 , MT1MMP , MTMMP1 , Membrane type 1-MMP , matrix metalloproteinase 14 (membrane-inserted) , membrane-type matrix metalloproteinase 1 , type 1 matrix metalloprotease 14 , matrix metalloproteinase 14 membrane-inserted , matrix metalloproteinase 14, membrane-inserted , membrane type 1-matrix metalloproteinase , MT1-MMP , matrix metalloproteinase 14 preproprotein , matrix metallopeptidase 1 (interstitial collagenase) , matrix metalloproteinase 14 , membrane type 1 metalloproteinase , membrane-type 1 matrix metalloproteinase , membrane type-1 metalloproteinase

GENE ID SPEZIES
594950 Xenopus (Silurana) tropicalis
4323 Homo sapiens
17387 Mus musculus
81707 Rattus norvegicus
281915 Bos taurus
100009598 Oryctolagus cuniculus
397471 Sus scrofa
443116 Ovis aries
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