CD44 Proteine (CD44)

CD44 Proteine (CD44)
Auf finden Sie aktuell 35 CD44 Proteine von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CD44 Antikörper (1569) und CD44 Kits (58) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1674 CD44 Produkte verfügbar.
AU023126, AW121933, AW146109, CD44A, CDW44, CSPG8, ECMR-III, HCELL, HERMES, HUTCH-I, IN, LHR, Ly-24, MC56, MDU2, MDU3, METAA, MIC4, Pgp-1, Pgp1, RHAMM
alle Proteine anzeigen Gen GeneID UniProt
CD44 12505 P15379
CD44 25406  
CD44 960 P16070

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Am meisten referenzierte CD44 Proteine

  1. Human CD44 Protein expressed in Wheat germ - ABIN1348653 : Gebhard, Jain, Nair, Emmons, Argilagos, Koomen, McLaughlin, Hazlehurst: MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. in Molecular cancer therapeutics 2013 (PubMed)
    Zeige alle 2 Referenzen für 1348653

  2. Human CD44 Protein expressed in HEK-293 Cells - ABIN2713719 : Zhang, Jia, Wang, Li, Hou, Yin, Wang, He, Lu: A CD44 specific peptide developed by phage display for targeting gastric cancer. in Biotechnology letters 2015 (PubMed)

  3. Human CD44 Protein expressed in HEK-293 Cells - ABIN2180800 : Hanley, Burdick, Konstantopoulos, Sackstein: CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. in Cancer research 2005 (PubMed)

Weitere Proteine zu CD44 Interaktionspartnern

Mouse (Murine) CD44 Interaktionspartner

  1. study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production

  2. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.

  3. OA/GPNMB acts through ERK (zeige EPHB2 Proteine) and AKT (zeige AKT1 Proteine) signaling pathways in mesenchymal stem cells via CD44

  4. These findings support the usefulness of the conditional Cd44 allele in unraveling essential physiological and pathological functions of CD44 isoforms.

  5. CD44 role in the atrophic epidermis

  6. CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis.

  7. CD44V6 is part of a positive-feedback loop with TGFbeta1 (zeige TGFB1 Proteine)/TGFbetaRI signaling that acts to increase NOX4 (zeige NOX4 Proteine)/ROS (zeige ROS1 Proteine) production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.

  8. HAS2 (zeige HAS2 Proteine)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (zeige MAPK3 Proteine)/EGR1 (zeige EGR1 Proteine) signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (zeige TGFB1 Proteine)-stimulated CD44V6/ERK (zeige EPHB2 Proteine)/EGR1 (zeige EGR1 Proteine) signaling.

  9. CD44 promotes accumulation of M2 macrophages, extracellular matrix deposition, and wall thickening during arteriovenous fistula maturation.

  10. CD44-expressing Neural Stem Cells are self-renewing and multipotent and they synthesize Hyaluronan that accumulates with aging. CD44-null Neural Stem Cells demonstrate increased proliferation in vitro and in vivo.

Pig (Porcine) CD44 Interaktionspartner

  1. Increased CD44s protein and posttranslational modification of CD44 with polylactosamine on macrophages from stage III could be involved in the cleaning up apoptotic granulosa cells

  2. CD44 has a key role in oocyte maturation but not in cumulus expansion.

  3. This study demonstrates that the CD14 (zeige CD14 Proteine)-negative isolation yields an enhanced cell population SFB (zeige CEBPB Proteine) that is more potent than MSCP (zeige SLC25A37 Proteine) as a cell source for cartilage tissue engineering.

  4. CD44 is expressed in the cumulus-oocyte complexes during cumulus expansion. The interaction between hyaluronan and CD44 is closely related to gap junctional communication of the cumulus-oocyte complexes during meiotic resumption.

Human CD44 Interaktionspartner

  1. CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin (zeige LTF Proteine) expression was upregulated (P < 0.0005).

  2. In clinical specimens of breast cancer, authors established that the expression of CD44s and HAS2 (zeige HAS2 Proteine) was positively correlated. Results establish a positive feedback mechanism that sustains PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling in tumor cells, further illuminating the nearly universal role of this pathway in cancer cell survival.

  3. In regulation of tumour cells with high CD44 expression.

  4. ZEB1-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 (zeige ESRP1 Proteine) and CD44 contribute to early pathogenesis and metastatic potential in established lung cancer

  5. In conclusion, CD44 and Oct3/4 (zeige POU5F1 Proteine) overexpression may imply malignant transformation of pancreatic ducts and could help pathologists make a more accurate diagnosis and decision on clear surgical margins.

  6. Expression analyses of miR (zeige MLXIP Proteine)-383 in PCa (zeige FLVCR1 Proteine) clinical tissues established that low miR (zeige MLXIP Proteine)-383 expression is associated with poor prognosis. Functional data suggest that miR (zeige MLXIP Proteine)-383 regulates PCa (zeige FLVCR1 Proteine) tumor-initiating/stem-like cells via CD44 regulation. Ectopic expression of miR (zeige MLXIP Proteine)-383 inhibited tumor-initiating capacity of CD44+ PCa (zeige FLVCR1 Proteine) cells

  7. our data demonstrated that FOXO3 is essential for CD44 expression and the properties of cancer stem cells (CSCs). Our data also indicated that patients with high FOXO3 activation signatures had poor prognoses. This evidence suggested that cGMP induction and FOXO3 inhibition could be ideal candidates for pancreatic CSC

  8. CD44, both a functional biomarker and therapeutic target, promoted CD133(+) CD44(+) lung cancer stem cell-like cells metastasis by Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)-FoxM1 (zeige FOXM1 Proteine)-Twist signaling.

  9. CD133 and CD44 in glioblastoma stem cells have roles in cell proliferation, phenotype stability and intra-tumor heterogeneity

  10. SRGN (zeige SRGN Proteine) secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44

Cow (Bovine) CD44 Interaktionspartner

  1. CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2 (zeige HYAL2 Proteine).

  2. release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.

  3. CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro

  4. determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25 (zeige IL2RA Proteine), CD44, and CD62L (zeige SELL Proteine) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.

  5. detection of CD44 in the bovine oviductal epithelium

  6. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM (zeige HMMR Proteine)-mediated signalling pathways involving Cdc2 (zeige CDK1 Proteine) and gamma-adducin (zeige ADD3 Proteine).

  7. The novel finding that TSP-1 (zeige THBS1 Proteine)-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 (zeige THBS1 Proteine) and HyA (zeige KDM5D Proteine)).

Horse (Equine) CD44 Interaktionspartner

  1. An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.

CD44 Protein Überblick

Protein Überblick

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Alternative names and synonyms associated with CD44

  • CD44 antigen (Cd44)
  • CD44 antigen-like (LOC100525150)
  • Cd44 molecule (Cd44)
  • CD44 molecule (Indian blood group) (CD44)
  • syndecan 4 (SDC4)
  • AU023126 Protein
  • AW121933 Protein
  • AW146109 Protein
  • CD44A Protein
  • CDW44 Protein
  • CSPG8 Protein
  • ECMR-III Protein
  • HCELL Protein
  • HERMES Protein
  • HUTCH-I Protein
  • IN Protein
  • LHR Protein
  • Ly-24 Protein
  • MC56 Protein
  • MDU2 Protein
  • MDU3 Protein
  • METAA Protein
  • MIC4 Protein
  • Pgp-1 Protein
  • Pgp1 Protein
  • RHAMM Protein

Bezeichner auf Proteinebene für CD44 Proteine (CD44)

ECMR-III , GP90 lymphocyte homing/adhesion receptor , HUTCH-I , PGP-I , extracellular matrix receptor III , hermes antigen , hyaluronate receptor , lymphocyte antigen 24 , phagocytic glycoprotein 1 , phagocytic glycoprotein I , CD44 antigen , Cell surface glycoprotein CD44 (hyaluronate binding protein) , PGP-1 , Hermes antigen , cell surface glycoprotein CD44 , chondroitin sulfate proteoglycan 8 , epican , hematopoietic cell E- and L-selectin ligand , heparan sulfate proteoglycan , homing function and Indian blood group system , extracellular matrix receptor-III , CD44-like protein , lymphocyte surface antigen precursor CD44 , syndecan 4 (amphiglycan, ryudocan) , syndecan-4

12505 Mus musculus
100750640 Cricetulus griseus
100525150 Sus scrofa
25406 Rattus norvegicus
960 Homo sapiens
403939 Canis lupus familiaris
101098744 Felis catus
281057 Bos taurus
395666 Gallus gallus
101113884 Ovis aries
100034221 Equus caballus
100301546 Oryctolagus cuniculus
419184 Gallus gallus
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