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By downregulating TRAIL-R1, TGFbeta1 (zeige TGFB1 Proteine) may not only promote tumor escape from immune surveillance but also negatively impact on TRAIL- or TRAIL-R1-based therapy regimens for treatment of Pancreatic ductal adenocarcinoma.
Results show that downregulation of DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) by SLC26A2 (zeige SLC26A2 Proteine) confers resistance to TRAIL.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (zeige HLADRB4 Proteine) expression in p53 (zeige TP53 Proteine)-dependent manner and inhibiting NF-kappaB (zeige NFKB1 Proteine) activity.
findings together highlight a previously undiscovered mechanism that positively regulates DR4 (zeige HLADRB4 Proteine) expression through activation of the MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine)/AP-1 (zeige FOSB Proteine) signaling pathway.
results suggest that the altered TRAIL, DR4 (zeige HLADRB4 Proteine) alleles and sTRAIL levels may be associated with some other potential biomarkers for vitiligo (zeige MITF Proteine)
The nanovectorization of TRAIL enhanced its binding to both DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) receptors at 37 degrees C and could potentially sensitized cancer cells to TRAIL induced apoptosis through simultaneous activation of DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) as described in this paper for the non-small lung carcinoma cell line (H1703), the two hepatocarcinoma cell lines (SK-Hep1, HUH) and the colon carcinoma cell line (HCT116WT).
Pro-survival effects by NF-kappaB (zeige NFKB1 Proteine), Akt (zeige AKT1 Proteine) and ERK(1 (zeige MAPK3 Proteine)/2) and anti-apoptosis actions by Six1 (zeige SIX1 Proteine) disrupt apoptotic functions of TRAIL-Dr4 (zeige HLADRB4 Proteine)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Bee venom inhibits colon cancer cell growth, and these anti-proliferative effects may be related to the induction of apoptosis by activation of DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) and inhibition of NF-kappaB (zeige NFKB1 Proteine) activity.
study involving a relatively large sample size showed that TNFRSF10 eQTL (zeige EQTN Proteine) SNPs within lncRNAs might influence both hepatocellular carcinoma development and HBV infection
Study investigated the association between colorectal cancer and polymorphisms in TRAIL and DR4 (zeige HLADRB4 Proteine) gene in Pakistani patients; TRAIL gene 1595 C>T genotypes percentage in colorectal cancer patients was statistically non-significant; for DR4 (zeige HLADRB4 Proteine) A1322G, homozygous GG genotype was 36% in the patients and in controls: there was statistically insignificant difference (p> 0.05).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
TNF-related apoptosis-inducing ligand receptor 1
, TRAIL receptor 1
, cytotoxic TRAIL receptor
, death receptor 4
, tumor necrosis factor receptor superfamily member 10A
, tumor necrosis factor receptor superfamily member 10a variant 2
, tumor necrosis factor receptor superfamily, member 10a
, tumor necrosis factor receptor superfamily member 10A-like