EpCAM Antikörper

Produktnummer ABIN614761

Produktdetails anti-EpCAM Antikörper

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EpCAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Spezifität: This antibody recognizes CD326 / EpCAM, a marker of epithelial lineages, that is over-expressed in many carcinomas.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure by SDS-PAGE

Immunogen: Human breast cancer MCF-7 cells

Klon: 323-A3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 15 mM Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-EpCAM Antikörper (ABIN614761)

Dvorakova, Vranac, Janouskova, ?ernilec, Koren, Lukan, Nováková, Matej, Holada, ?urin Šerbec: "Detection of the GPI-anchorless prion protein fragment PrP226* in human brain." in: BMC neurology, Vol. 13, pp. 126, (2013) (PubMed).

Kirman, Jenkins, Fowler, Whelan: "Naturally occurring antibodies to epithelial cell adhesion molecule (EpCAM)." in: Digestive diseases and sciences, Vol. 48, Issue 12, pp. 2306-9, (2004) (PubMed).

Winter, Nagtegaal, van Krieken, Litvinov: "The epithelial cell adhesion molecule (Ep-CAM) as a morphoregulatory molecule is a tool in surgical pathology." in: The American journal of pathology, Vol. 163, Issue 6, pp. 2139-48, (2003) (PubMed).

Balzar, Briaire-de Bruijn, Rees-Bakker, Prins, Helfrich, de Leij, Riethmüller, Alberti, Warnaar, Fleuren, Litvinov: "Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions." in: Molecular and cellular biology, Vol. 21, Issue 7, pp. 2570-80, (2001) (PubMed).

Balzar, Bakker, Briaire-de-Bruijn, Fleuren, Warnaar, Litvinov: "Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule." in: Molecular and cellular biology, Vol. 18, Issue 8, pp. 4833-43, (1998) (PubMed).

Litvinov, Bakker, Gourevitch, Velders, Warnaar: "Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion." in: Cell adhesion and communication, Vol. 2, Issue 5, pp. 417-28, (1995) (PubMed).

Litvinov, Velders, Bakker, Fleuren, Warnaar: "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule." in: The Journal of cell biology, Vol. 125, Issue 2, pp. 437-46, (1994) (PubMed).

Fukudome, Furuse, Imai, Nishimura, Takagi, Hinuma, Yoshie et al.: "Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen ..." in: Journal of virology, Vol. 66, Issue 3, pp. 1394-401, (1992) (PubMed).

Details zu EpCAM

Target: EpCAM (EPCAM) (Epithelial Cell Adhesion Molecule (EPCAM))

Andere Bezeichnung: CD326 / EPCAM / TACSTD1 (EPCAM Produkte)

Synonyme: DIAR5 antikoerper, EGP-2 antikoerper, EGP314 antikoerper, EGP40 antikoerper, ESA antikoerper, HNPCC8 antikoerper, KS1/4 antikoerper, KSA antikoerper, M4S1 antikoerper, MIC18 antikoerper, MK-1 antikoerper, TACSTD1 antikoerper, TROP1 antikoerper, ECS-1 antikoerper, ECS1 antikoerper, ESA1 antikoerper, M17S1 antikoerper, EGP antikoerper, Ep-CAM antikoerper, sb:cb6 antikoerper, tacstd antikoerper, wu:fj17g02 antikoerper, zgc:110304 antikoerper, zgc:77119 antikoerper, tacstd1 antikoerper, MGC80540 antikoerper, EPCAM antikoerper, egp antikoerper, ksa antikoerper, m4s1 antikoerper, mk-1 antikoerper, cd326 antikoerper, egp40 antikoerper, mic18 antikoerper, trop1 antikoerper, ep-cam antikoerper, hegp-2 antikoerper, co17-1a antikoerper, ga733-2 antikoerper, CD326 antikoerper, Egp314 antikoerper, EpCAM1 antikoerper, GA733-2 antikoerper, Ly74 antikoerper, Tacsd1 antikoerper, Tacstd1 antikoerper, gp40 antikoerper, epithelial cell adhesion molecule antikoerper, flotillin 2 antikoerper, epithelial cell adhesion molecule S homeolog antikoerper, EPCAM antikoerper, FLOT2 antikoerper, epcam antikoerper, epcam.S antikoerper, Epcam antikoerper

Hintergrund: CD326 / EpCAM (also known as ESA, EGP40, EGP-2, KSA1/4, CO17-1A, GA733-2, MOC31, Ber-EP4) is a 40 kDa transmembrane glycoprotein serving as adhesion molecule in the basolateral membranes in a variety of epithelial cells. CD326 mediates calcium-independent homotypic cell-cell adhesions. CD326 over-expression has been detected in many epithelial tumours and is often associated with bad prognosis. It has been used for diagnostics of (pre-) malignancies at early stages.Synonyms: Adenocarcinoma-associated antigen, EGP314, Ep-CAM, Epithelial cell adhesion molecule, Epithelial glycoprotein 314, GA733-2, KS 1/4 antigen, KSA, M1S2, M4S1, MIC18, Major gastrointestinal tumor-associated protein GA733-2, TROP1, Trop-1, Tumor-associated calcium signal transducer 1

Gen-ID: 4072

NCBI Accession: NP_002345

UniProt: P16422