Cytokeratin 13 (KRT13) Antikörper

Details zu Produkt Nr. ABIN335313, Anbieter: Anmelden zum Anzeigen
  • CK13
  • K13
  • Krt-1.13
  • Krt1-13
  • keratin 13
  • KRT13
  • Krt13
Human, Rind (Kuh), Ratte (Rattus)
Klonalität (Klon)
Monoklonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen Ks13.1 is a mouse monoclonal IgG1 antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a cytokeratin preparation extracted from human esophagus.
Klon Ks13-1
Isotyp IgG1
Spezifität Ks13.1 reacts exclusively with cytokeratin 13 which is present in non-cornified squamous epithelia, except cornea, and transitional epithelial regions, with the exception of basal cell layers of some stratified epithelia. As a result the antibody also reacts with neoplasms derived from these epithelia.
Andere Bezeichnung Cytokeratin 13 / Keratin K13 (KRT13 Antibody Abstract)
Hintergrund Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 – 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Forschungsgebiet Extracellular Matrix
Applikationshinweise Ks13.1 is suitable for immunoblotting and immunohistochemistry on frozen tissues and paraffin embedded tissue after protease pretreatment. Optimal antibody dilution should be determined by titration.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Each vial contains 1 ml of culture supernatant containing 0.09% sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Produkt verwendet in: Demirkesen, Hoede, Moll: "Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins." in: Journal of cutaneous pathology, Vol. 22, Issue 6, pp. 518-35, 1996 (PubMed).

Dallenbach-Hellweg, Lang: "Immunohistochemical studies on uterine tumors. I. Invasive squamous cell carcinomas of the cervix and their precursors." in: Pathology, research and practice, Vol. 187, Issue 1, pp. 36-43, 1991 (PubMed).

Moll, Achtstätter, Becht, Balcarova-Ständer, Ittensohn, Franke: "Cytokeratins in normal and malignant transitional epithelium. Maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines." in: The American journal of pathology, Vol. 132, Issue 1, pp. 123-44, 1988 (PubMed).

Dockhorn-Dworniczak, Franke, Schröder, Czernobilsky, Gould, Böcker: "Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas." in: Differentiation; research in biological diversity, Vol. 35, Issue 1, pp. 53-71, 1988 (PubMed).

Moll, Franke, Schiller, Geiger, Krepler: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).