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Human T-lymphotropic virus 1 Tax (zeige CNTN2 ELISA Kits) protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 (zeige TBK1 ELISA Kits) to evade host innate immunity.
STING activated an antiviral/type I interferon (zeige IFNA ELISA Kits) response with live but not killed S. aureus.
study identifies the AIM2 (zeige AIM2 ELISA Kits) inflammasome and cGAS/IFI16 (zeige IFI16 ELISA Kits)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
NEMO (zeige IKBKG ELISA Kits) was critically involved in the cGAS-STING pathway.
Studied association of genetic variants of the MAVS, MITA and MFN2 genes with leprosy in Han Chinese from Southwest China; found no association between the variants and susceptibility to leprosy.
both IL-6 (zeige IL6 ELISA Kits) and RIG-I (zeige DDX58 ELISA Kits) are downstream molecules of STING along the DNA sensor pathway.
We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (zeige CECR1 ELISA Kits) (DADA2), a subtype of macrophage activation syndrome (MAS (zeige MAS1 ELISA Kits)), and stimulator of interferon (zeige IFNA ELISA Kits) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (zeige MEFV ELISA Kits)
Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (zeige IFNA ELISA Kits) signaling
a critical role of p38 (zeige CRK ELISA Kits)-mediated USP21 (zeige USP21 ELISA Kits) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (zeige CRK ELISA Kits)-USP21 (zeige USP21 ELISA Kits) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.
Data show that stimulator of interferon (zeige IFNA ELISA Kits) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3 (zeige IRF3 ELISA Kits)-independent immune cell dysregulation and lung disease in mice.
These results highlight the crucial role of MFN1 (zeige MFN1 ELISA Kits) in maintaining the competency of the STING pathway.
to contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin (zeige BST2 ELISA Kits), a viral restriction factor
found that CCCP impairs the interaction between STING and TBK1 (zeige TBK1 ELISA Kits) and concomitantly triggers mitochondria fission.
Yersinia YopJ negatively regulates IRF3 (zeige IRF3 ELISA Kits)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
demonstrate that in colon tumor model, therapeutic anti-CD47 (zeige CD47 ELISA Kits) preferentially relies on STING-mediated DNA sensing in dendritic cells
STING is a central mediator of interferon (zeige IFNA ELISA Kits) regulated inflammasome activation in Chlamydia trachomatis infection.
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173