SIN3A Proteine (SIN3A)

Bezeichnung:
SIN3 Transcription Regulator Homolog A (Yeast) Proteine (SIN3A)
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Synonyme:
AW553200, mKIAA4126, mSin3A, Sin3
alle Proteine anzeigen Gen GeneID UniProt
SIN3A 25942 Q96ST3
Ratte SIN3A SIN3A 363067  
SIN3A 20466 Q60520

Weitere Synonyme anzeigen

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Human SIN3 Transcription Regulator Homolog A (Yeast) (SIN3A) Interaktionspartner

  1. Haploinsufficiency of SIN3A causes mild intellectual disability by affecting the development of cortical integrity.

  2. Two novel translocations leading to the inactivation of RUNX1 (zeige RUNX1 Proteine) and its partners SIN3A and TCF12 (zeige TCF12 Proteine) in myeloid leukemia (zeige BCL11A Proteine).

  3. Study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by Sertoli cell-only syndrome in humans.

  4. down regulation of miR (zeige MLXIP Proteine)-202 increased the expression of its target Mxd1 (zeige MXD1 Proteine), followed by Mxd1 (zeige MXD1 Proteine) recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc (zeige MYC Proteine)-Max target proteins.

  5. protein pairs significantly correlated with an increased risk of death in non-small cell lung cancer: mSin3A with p16, and c-Myc (zeige MYC Proteine) with mSinA

  6. Aberrantly expressed miR (zeige MLXIP Proteine)-210 regulates human U251 glioma cells apoptosis and proliferation partly through directly down-regulating SIN3A protein expression.

  7. Bone-marrow-specific deletion of Sin3a, indicated that Sin3a-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis.

  8. SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor (zeige AHR Proteine).

  9. EBNA3C binds strongly to BATF/IRF4/SPI1/RUNX3 sites to enhance transcription and recruits RBPJ/Sin3A- and REST/NRSF-repressive complexes to repress p14(ARF) and p16(INK4A) expression

  10. BIM (zeige BCL2L11 Proteine) silencing in anaplastic large cell lymphoma occurs through recruitment of MeCP2 (zeige MECP2 Proteine) and the SIN3a/histone deacetylase 1/2 corepressor complex.

Mouse (Murine) SIN3 Transcription Regulator Homolog A (Yeast) (SIN3A) Interaktionspartner

  1. Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac (zeige HDAC3 Proteine) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.

  2. TGF-beta1 (zeige TGFB1 Proteine)-induced inhibition of PPARgamma (zeige PPARG Proteine) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3 (zeige SMAD3 Proteine), mSin3A and HDAC1 (zeige HDAC1 Proteine) at the PPARgamma (zeige PPARG Proteine) promoter.

  3. Sin3a mRNA is recruited during maturation and that inhibiting its recruitment not only inhibits development beyond the 2-cell stage but also compromises the fidelity of reprogramming gene expression

  4. Report role of myocardial mSin3A/HDAC1 (zeige HDAC1 Proteine)/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy.

  5. SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor (zeige AHR Proteine).

  6. Treatment with GlcN, in contrast, inhibits LPS (zeige TLR4 Proteine)-ind inflammation and decreased LPS (zeige TLR4 Proteine)-mediated recruitment of OGT (zeige OGT Proteine), mSin3A, and HDACs.

  7. Within the male germline, Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes.

  8. Sin3A-deleted testes exhibit a Sertoli-cell only phenotype, consistent with the absolute requirement for Sin3A in germ cells' development and/or viability.

  9. Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population

  10. ARID4B physically interacts with the breast cancer metastasis suppressor BRMS1 (zeige BRMS1 Proteine), and we detected differential binding of the Arid4b alleles to mSIN3A and mSDS3 (zeige SUDS3 Proteine)

SIN3A Protein Überblick

Protein Überblick

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.

Alternative names and synonyms associated with SIN3A

  • SIN3 transcription regulator homolog A (yeast) (SIN3A)
  • SIN3 homolog A, transcription regulator (yeast) (SIN3A)
  • SIN3 transcription regulator family member A (SIN3A)
  • SIN3 transcription regulator homolog A (yeast) (Sin3a)
  • transcriptional regulator, SIN3A (yeast) (Sin3a)
  • AW553200 Protein
  • mKIAA4126 Protein
  • mSin3A Protein
  • Sin3 Protein

Bezeichner auf Proteinebene für SIN3A

SIN3 homolog A, transcription regulator , transcriptional co-repressor Sin3A , paired amphipathic helix protein Sin3a , SIN3 homolog A, transcription regulator (yeast) , paired amphipathic helix protein Sin3a-like , SIN3 transcription regulator homolog A , histone deacetylase complex subunit Sin3a , transcriptional corepressor Sin3a , transcriptional regulator, SIN3A , transcriptional regulator, SIN3 yeast homolog A

GENE ID SPEZIES
453759 Pan troglodytes
478372 Canis lupus familiaris
518504 Bos taurus
705719 Macaca mulatta
100404916 Callithrix jacchus
100477344 Ailuropoda melanoleuca
100641919 Amphimedon queenslandica
25942 Homo sapiens
415307 Gallus gallus
363067 Rattus norvegicus
20466 Mus musculus
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