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Human MMP2 Protein expressed in Human Cells - ABIN2002031
Brooks, Silletti, von Schalscha, Friedlander, Cheresh: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. in Cell 1998
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Human MMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1080273
Zheng, Hu, Huang, Xu, Yang, Li: In vivo bioengineered ovarian tumors based on collagen, matrigel, alginate and agarose hydrogels: a comparative study. in Biomedical materials (Bristol, England) 2015
study demonstrated that matrix metalloproteinase 1 (zeige MMP1 Proteine) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
Data indicate that matrix metalloproteinases mmp1 (zeige MMP1 Proteine) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (zeige CA2 Proteine)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (zeige WNT4 Proteine) signaling antagonist, MMP2 cleaves the glypican (zeige GPC1 Proteine), reducing the ability of Dlp (zeige DMD Proteine) to interact with the Wnt (zeige WNT4 Proteine) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (zeige ADCY10 Proteine) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (zeige MMP9 Proteine) in the embryonic zebrafish.
MMP-2 and -9 expression were suppressed significantly by treatment with SB-3CT. The data demonstrated, for the first time, that SB-3CT strongly reduced corneal lymphangiogenesis and macrophage infiltration during inflammation.
animals were submitted to the evaluation of Blood-Brain Barrier permeability and MMP-2 and MMP-9 (zeige MMP9 Proteine) in striatum, hippocampus and cerebral cortex
High MMP2 expression is associated with abdominal aortic aneurysm.
Low MMP2 expression is associated with liver fibrosis.
Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 (zeige MMP9 Proteine) were knocked out in gamma - sarcoglycan (zeige SGCG Proteine)-deficient mice. The study found that up-regulation of MMP-14 (zeige MMP14 Proteine) is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
NH2-terminal truncated MMP-2 "primes" the kidney to enhanced susceptibility to I-R injury via induction of mitochondrial dysfunction.
Study demonstrated evidence of beta-dystroglycan cleavage by matrix metalloproteinase-2/-9 in permanent middle cerebral artery occlusion mouse brains; this cleavage was implicated in aquaporin-4 (zeige AQP4 Proteine) redistribution and brain edema in cerebral ischemia.
These results indicate that increased MMP2 and MMP9 (zeige MMP9 Proteine) activity in the brains of mouse adenovirus type 1-infected susceptible mice may be due to MMP activity produced by endothelial cells, astrocytes, and microglia, which in turn may contribute to blood-brain barrier disruption and encephalitis in susceptible mice.
Studies define a novel HMGA1 (zeige HMGA1 Proteine)-MMP-2 pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.
activation of astrocyte MMP2/JNK1 (zeige MAPK8 Proteine)/2 contributes to the pathogenesis of pain hypersensitivity in the complex regional pain syndrome model
Concentrations of MMP-2 and MMP-9 (zeige MMP9 Proteine) in serum in humans measured after acute stroke are potentially influenced by extraneous covariates rather than being directly associated with characteristics of the underlying stroke.
There were no differences in activities of MMP-2, proMMP-9, and MMP-9 (zeige MMP9 Proteine)/NGAL (neutrophil gelatinase associated lipocalin (zeige LCN2 Proteine)) complex (gelatin substrate) in men with detected prostate cancer, although the latter two were somewhat diminished.
Data indicate that the matrix metallopeptidases MMP-2/MMP-9 (zeige MMP9 Proteine) ratio provided better compromise between specificity and sensitivity in distinguishing PE from normal pregnancies, than either of the two MMPs alone.
The A/A genotype (OR=0.120) and A allele (OR=0.442) reduce the risk of recurrent depressive disorder occurrence in the examined polymorphisms for MMP-2, MMP-7 (zeige MMP7 Proteine) and MMP-9 (zeige MMP9 Proteine).
Data suggest that MMP2 expression in lung neoplasms can be regulated by dietary factors; here, metabolites of quercetin (an antioxidant, anticarcinogenic dietary supplement) quercetin-3-glucuronide and quercetin 3'-sulfate down-regulates expression of MMP2 in A549 cells; the mechanism for this enzyme repression appears to involve up-regulation of PPARgamma (zeige PPARG Proteine).
MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA (zeige VEGFA Proteine), VEGFR1 (zeige FLT1 Proteine), VEGFR2 (zeige KDR Proteine), HGF (zeige HGF Proteine) and MMP2
Expression of MMP2 is suppressed by Rubus idaeus extract by down-regulating ERK1/2 signaling pathway.
The rates of CD44st and MMP2 expression were higher in squamous cell carcinomas than in adenocarcinomas, were closely associated with lymph node metastasis and TNM (zeige ODZ1 Proteine) stage, and affected patients' prognoses.
characteristics involving MMP-2 and MMP-9 (zeige MMP9 Proteine) in Chagas' disease to clarify their participation on the inflammation/regulation and fibrosis, and the synergistic or antagonistic role between them [Review]
This study showed a significantly greater prevalence of the C/C and C/T genotypes in the patients with age-related macular degeneration (AMD (zeige AMD1 Proteine)) younger than 65 years and those aged >/=65 years, respectively.
this study shows that differential FFAR1 signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (zeige NOX1 Proteine) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (zeige DYM Proteine) proliferation occurs through the involvement of Spm (zeige NPC1 Proteine)-Cer (zeige CBLN1 Proteine)-S1P (zeige MBTPS1 Proteine) signaling axis under ANG II (zeige AGT Proteine) stimulation of PASMCs
The expression patterns of MMP1 (zeige MMP1 Proteine), MMP2, and MMP8 (zeige MMP8 Proteine) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (zeige MMP1 Proteine), MMP2, and MMP8 (zeige MMP8 Proteine) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (zeige MMP1 Proteine), MMP2, and MMP8 (zeige MMP8 Proteine) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (zeige MMP1 Proteine) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (zeige MMP9 Proteine) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (zeige PKCa Proteine) in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Proteine) expression by NF-kappaB (zeige NFKB1 Proteine)-MT1-MMP (zeige MMP14 Proteine)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (zeige MMP14 Proteine)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 (zeige TIMP2 Proteine) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (zeige MMP14 Proteine), MMP-2 and TIMP-2 (zeige TIMP2 Proteine) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (zeige MMP9 Proteine), TIMP1 (zeige TIMP1 Proteine), and NGAL (zeige LCN2 Proteine) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (zeige MMP9 Proteine) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (zeige MMP9 Proteine) and MMP-2, caspase-3 (zeige CASP3 Proteine) and BDNF (zeige BDNF Proteine)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (zeige MMP14 Proteine) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (zeige CSF2 Proteine) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (zeige MMP9 Proteine) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2, VEGFR-1 (zeige FLT1 Proteine), VEGFR-2 (zeige KDR Proteine), and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.
Inflammatory factors such as TNF-alpha (zeige TNF Proteine) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (zeige DMD Proteine).
Castor oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (zeige AMBP Proteine) effectively inhibited the increased expression of MMP-2, MMP-3 (zeige MMP3 Proteine), and iNOS (zeige NOS2 Proteine) in degenerated NP cells induced by IL-1beta (zeige IL1B Proteine) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (zeige MMP9 Proteine) and TIMP-1 (zeige TIMP1 Proteine) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)