TGFB1 Proteine (TGFB1)

Bezeichnung:
Transforming Growth Factor, beta 1 Proteine (TGFB1)
Auf www.antikoerper-online.de finden Sie aktuell 121 Transforming Growth Factor, beta 1 (TGFB1) Proteine von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TGFB1 Antikörper (465) und TGFB1 Kits (196) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 805 TGFB1 Produkte verfügbar.
Synonyme:
ai39657, betaig-h3, bigh3, cdb1, cdg2, cdgg1, ced, csd, csd1, csd2, csd3, dpd1, ebmd, lap, lcd1, MGC146225, tgf, tgf-beta, TGF-BETA-1, TGF-beta1, TGF-beta5, tgfb, Tgfb-1, TGFB1, TGFB4, tgfb5, tgfbeta, TGFbeta1, TGFBI, wu:fb13a07, xx:ai39657
alle Proteine anzeigen Gen GeneID UniProt
TGFB1 7040 P01137
TGFB1 59086 P17246
TGFB1 21803 P04202

Weitere Synonyme anzeigen

TGFB1 Proteine (TGFB1) nach Spezies

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Am meisten referenzierte TGFB1 Proteine

  1. Human TGFB1 Protein expressed in CHO Cells - ABIN2666973 : Acosta-Rodriguez, Napolitani, Lanzavecchia, Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. in Nature immunology 2007 (PubMed)
    Zeige alle 13 Referenzen für 2666973

  2. Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188 : Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983 (PubMed)
    Zeige alle 4 Referenzen für 2009188

  3. Dog (Canine) TGFB1 Protein expressed in Human Cells - ABIN2008955 : Letterio, Roberts: Regulation of immune responses by TGF-beta. in Annual review of immunology 1998 (PubMed)
    Zeige alle 3 Referenzen für 2008955

  4. Human TGFB1 Protein expressed in HEK293 - ABIN2039654 : Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997 (PubMed)
    Zeige alle 3 Referenzen für 2039654

  5. Human TGFB1 Protein expressed in CHO Cells - ABIN2003410 : Vaughn, Broussard, Hall, Scott, Blanton, Milunsky, Hecht: Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. in Genomics 2000 (PubMed)
    Zeige alle 3 Referenzen für 2003410

  6. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2181808 : Derynck, Jarrett, Chen, Eaton, Bell, Assoian, Roberts, Sporn, Goeddel: Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. in Nature 1985 (PubMed)

  7. Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505 : Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015 (PubMed)

Weitere Proteine zu TGFB1 Interaktionspartnern

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. TGF-beta1 regulated pAKT (zeige AKT1 Proteine) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

  2. These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF (zeige VEGFA Proteine), CXCR4 (zeige CXCR4 Proteine), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

  3. SIV infection of rhesus macaques results in the emergence of IL-17 (zeige IL17A Proteine)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (zeige IL18 Proteine) expression.

  4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (zeige CD8A Proteine)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

  2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (zeige LDB2 Proteine).

  3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (zeige SMAD5 Proteine) mediated pathway.

  4. PCSK7 (zeige PCSK7 Proteine) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

  5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

  6. TGFbeta1 plays a role in zebrafish keratocyte migration.

  7. data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (zeige SMAD4 Proteine) and preventing the formation of Smad2 (zeige SMAD2 Proteine)/3/4 and Smad1 (zeige SMAD1 Proteine)/5/9/4 complexes

  8. TGF-beta1 acts at multiple sites, including LH receptor (zeige LHCGR Proteine), 20beta-HSD (zeige HAL Proteine) and membrane progestin receptor-beta (zeige PAQR8 Proteine), to inhibit zebrafish oocyte maturation

  9. These data suggest Pez (zeige PTPN14 Proteine) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

  10. Data show that Rock2 (zeige ROCK2 Proteine) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

  2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (zeige SYCP3 Proteine) serves as a vegetally enriched, intrinsic factor (zeige GIF Proteine) to ensure a prepared status of Smads for their activation.

  3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

  4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

  5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (zeige SMAD4 Proteine)

  6. sortilin (zeige SORT1 Proteine) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. these studies characterize an accessory TGF-beta-stimulated BMP R-Smad (zeige SMAD1 Proteine) signaling mechanism in interstitial cells of the developing lung.

  2. The aim of the present study was to detect antibodies against Epstein-Barr virus and explore the levels of TGFbeta and IL-10 (zeige IL10 Proteine) in Polish gastric cancer patients.

  3. Excess expression of TGF-beta1 gene in pterygium tissue of atopic individuals suggests that growth factors play a role in the pathogenesis of pterygium

  4. Flightless-I (Drosophila) homolog (FLII (zeige FLII Proteine)) activates TGFbeta1-mediated expression of COL1A2 (zeige COL1A2 Proteine) gene.

  5. The transforming growth factor beta (TGF-beta) pathway is required for E-cadherin (zeige CDH1 Proteine) loss to induce inhibition of Nucleotide Excision Repair.

  6. The current study provides novel evidence that TGFbeta upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R (zeige IGF1R Proteine), EGFR (zeige EGFR Proteine), PDGFbetaR, and FGFR1 (zeige FGFR1 Proteine) in human hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cells. This, in turn, sensitized HCC (zeige FAM126A Proteine) cells to individual cognate RTK ligands, leading to cell survival.

  7. Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR (zeige AHR Proteine)) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma.

  8. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta.

  9. By linking leptin (zeige LEP Proteine) signalling to the established TGFB1 pathway of metastasis / EMT (zeige ITK Proteine).

  10. the results indicate prominent antagonistic effects of IL-1alpha on TGF-beta regulated interferon (zeige IFNA Proteine) signaling, as well as on a wide variety of other genes and pathways in fibroblasts.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. Activated TGF-beta signaling rescued miR (zeige MYLIP Proteine)-143-reduced FSHR (zeige FSHR Proteine) and intracellular signaling molecules, and miR (zeige MYLIP Proteine)-143-induced porcine granulosa cell apoptosis.

  2. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (zeige PTK2 Proteine)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (zeige PTK2 Proteine) signaling is inhibited.

  3. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (zeige SMAD1 Proteine) and MAPK (zeige MAPK1 Proteine) signal pathways in intestinal epithelium cells after TNF-alpha (zeige TNF Proteine) challenge

  4. this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (zeige EGFR Proteine) signaling pathways

  5. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

  6. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

  7. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (zeige IL10 Proteine), and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.

  8. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (zeige TGFB2 Proteine) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

  9. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (zeige MAPK14 Proteine) signaling, reduces CFTR (zeige CFTR Proteine) expression to impair CFTR (zeige CFTR Proteine)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (zeige CFTR Proteine) mutations and ultimately would compromise male fertility.

  10. High yield isolation of BMP-2 (zeige BMP2 Proteine) from bone and in vivo activity of a combination of BMP-2 (zeige BMP2 Proteine)/TGF-beta1.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (zeige FGF2 Proteine) expression through the activation of AP-1 (zeige JUN Proteine) and NF-kappaB (zeige NFKB1 Proteine) in bovine mammary gland fibroblasts.

  2. The results identify TGFB1 and ESRRA (zeige ESRRA Proteine) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

  3. the combined treatment with TGF-beta1 and BMP-7 (zeige BMP7 Proteine) or treatment first with TGF-beta1 followed by BMP-7 (zeige BMP7 Proteine) was more effective than other treatment groups in both chondrogenic differentiation and SZP (zeige PRG4 Proteine) secretion.

  4. Tenascin-X (zeige TNXB Proteine) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

  5. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).

  6. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

  7. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

  8. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.

  9. Role of TGF-beta1 and TNF-alpha (zeige TNF Proteine) in IL-1beta (zeige IL1B Proteine) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

  10. vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor (zeige FGF2 Proteine) and transforming growth factor beta(1) released by endothelial cells

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. inhibition of GLUT1 (zeige SLC2A1 Proteine) activity and/or expression is shown to impair TGF-beta-driven fibrogenic processes, including cell proliferation and production of profibrotic mediators

  2. Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (zeige SMN1 Proteine), and COL1a1 (zeige COL1A1 Proteine) expression in a liver fibrosis disease model.

  3. TAZ (zeige TAZ Proteine) is required for TGFbeta induction of smooth muscle genes in primary aortic vascular smooth muscle cells.

  4. Data suggest that Gas5 suppresses Tgfb1/Smad3 (zeige SMAD3 Proteine) signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 (zeige SMAD3 Proteine) via multiple RNA Smad (zeige SMAD1 Proteine)-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 = transforming growth factor beta 1; Smad3 (zeige SMAD3 Proteine) = MAD homolog 3 (zeige SMAD3 Proteine) protein)

  5. this study shows that TGF-beta1 exhibits improved pregnancy outcomes induced by Toxoplasma gondii infection

  6. this study shows that TGF-beta promotes salivary gland innate lymphoid cells differentiation by suppressing Eomes (zeige EOMES Proteine)

  7. protein expression and activity of Tgf-beta1 signaling in degenerative condylar cartilages

  8. These results suggest that DMSO, a fusogenic substance, enhances TGF-beta activity presumably by inducing fusion of cytoplasmic vesicles (containing TbetaR-II (zeige TGFBR2 Proteine)) and the plasma membrane, resulting in increased localization of TbetaR-II (zeige TGFBR2 Proteine) to non-lipid raft microdomains where canonical signaling occurs.

  9. selective inhibition of SMAD3 (zeige SMAD3 Proteine) or CCT6A (zeige CCT6A Proteine) efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma.

  10. TGFB1 activation is associated with liver fibrosis.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (zeige SMAD3 Proteine) signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (zeige NFKB1 Proteine), and the amelioration of disc degradation.

  4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (zeige ROCK1 Proteine) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

  5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

  6. Smad7 (zeige SMAD7 Proteine) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (zeige NOTCH1 Proteine) signaling target in limbal epithelial stem cells.

  7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

  8. After NOTCH1 (zeige NOTCH1 Proteine) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (zeige Vcan Proteine) and collagen II.

  9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

  10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. TGF beta is involved in the pathogenesis of tympanosclerosis.

  2. There was significantly higher expression of TGF-beta1 and MMP-9 (zeige MMP9 Proteine) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) Interaktionspartner

  1. Within the limitations of the study design, production of COMP (zeige COMP Proteine) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

  2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

TGFB1 Protein Überblick

Protein Überblick

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Alternative names and synonyms associated with TGFB1

  • transforming growth factor, beta 1 (TGFB1)
  • transforming growth factor, beta 1a (tgfb1a)
  • transforming growth factor, beta-induced, 68kDa (TGFBI)
  • transforming growth factor, beta-induced, 68kDa (tgfbi)
  • transforming growth factor, beta-induced, 68kDa (LOC100227786)
  • transforming growth factor beta 1 (TGFB1)
  • transforming growth factor, beta 1 (Tgfb1)
  • transforming growth factor, beta 1 (tgfb1)
  • transforming growth factor, beta 1 (tgf)
  • ai39657 Protein
  • betaig-h3 Protein
  • bigh3 Protein
  • cdb1 Protein
  • cdg2 Protein
  • cdgg1 Protein
  • ced Protein
  • csd Protein
  • csd1 Protein
  • csd2 Protein
  • csd3 Protein
  • dpd1 Protein
  • ebmd Protein
  • lap Protein
  • lcd1 Protein
  • MGC146225 Protein
  • tgf Protein
  • tgf-beta Protein
  • TGF-BETA-1 Protein
  • TGF-beta1 Protein
  • TGF-beta5 Protein
  • tgfb Protein
  • Tgfb-1 Protein
  • TGFB1 Protein
  • TGFB4 Protein
  • tgfb5 Protein
  • tgfbeta Protein
  • TGFbeta1 Protein
  • TGFBI Protein
  • wu:fb13a07 Protein
  • xx:ai39657 Protein

Bezeichner auf Proteinebene für TGFB1

transforming growth factor beta1 , transforming growth factor, beta 1 , transforming growth factor, beta-induced, 68kDa , transforming growth factor-beta-induced protein ig-h3-like , transforming growth factor beta-1-like , TGF-beta-1 , transforming growth factor beta 4 , transforming growth factor beta-1 , TGF-beta 1 protein , latency-associated peptide , transforming growth factor, beta 1 (Camurati-Engelmann disease) , transforming growth factor-beta-1 , TGF-beta 1 , transforming growth factor-beta 1 , transforming growth factor, beta-1 , transforming growth factor beta 1 , regulatory protein , transforming growth factor-beta , TGF-beta-5 , tgf beta , tgf-beta 5 , transforming gorwth factor-Beta5 , transforming growth factor-B5 , transforming growth factor-beta 5 , Transforming growth factor beta-1

GENE ID SPEZIES
574135 Macaca mulatta
359834 Danio rerio
768263 Felis catus
456060 Pan troglodytes
462081 Pan troglodytes
481519 Canis lupus familiaris
495971 Xenopus laevis
712503 Macaca mulatta
779782 Xenopus (Silurana) tropicalis
100227786 Taeniopygia guttata
100397340 Callithrix jacchus
100401979 Callithrix jacchus
100441300 Pongo abelii
100459982 Pongo abelii
100580274 Nomascus leucogenys
100581386 Nomascus leucogenys
100873157 Gallus gallus
7040 Homo sapiens
397078 Sus scrofa
443417 Ovis aries
59086 Rattus norvegicus
403998 Canis lupus familiaris
282089 Bos taurus
21803 Mus musculus
100008645 Oryctolagus cuniculus
100135628 Cavia porcellus
100033900 Equus caballus
397778 Xenopus laevis
100136774 Oncorhynchus mykiss
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