Ubiquilin 2 (UBQLN2) ELISA Kits

UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Zusätzlich bieten wir Ihnen Ubiquilin 2 Antikörper (60) und Ubiquilin 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
UBQLN2 29978 Q9UHD9
UBQLN2 54609 Q9QZM0
Anti-Ratte UBQLN2 UBQLN2 317396  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.64 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für Ubiquilin 2 Interaktionspartner

Human Ubiquilin 2 (UBQLN2) Interaktionspartner

  1. The structures of proteasome substrate receptor complexes with the shuttle factors that deliver ubiquitinated proteins to proteasomes have been solved, namely human Rpn13 (zeige Adrm1 ELISA Kits) complexed with PLIC2 and Saccharomyces cerevisiae Rpn1 (zeige PSMD2 ELISA Kits) with Rad23.

  2. Ubiquilins are a family of chaperones for cytosolically exposed transmembrane domains and use ubiquitin to triage clients for degradation via coordinated intra- and intermolecular interactions.

  3. We analyzed mutations in the UBQLN2 gene in a Chinese cohort with sporadic ALS (sALS). A novel missense mutation was detected in one sALS patient. The p.M392V mutation substitutes a highly conserved residue, has not been reported in the population databases, and previously, at the same residue, a missense mutation p.M392I was detected in two Turkey ALS patients and was considered to be pathogenic.

  4. Frontotemporal dementia -linked mutations in gene ubiquilin 2 encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  5. excess UBQLN2 is toxic rather than protective to neurons and that uncontrolled enhancement of UBQLN2 function is involved in UBQLN2 pathogenesis

  6. Ubiquilin-2 immunostaining - a new marker as a diagnostic supplement in urine cytology?

  7. UBQLN2 is specifically expressed in the urine of urothelial carcinoma patients.

  8. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3

  9. These findings provide a molecular basis for the development of ALS/FTD-associated proteinopathy and establish novel therapeutic targets for ALS.

  10. Mutations in UBQLN2 gene cause dominant inheritance of amyotrophic lateral sclerosis due to Defective Proteasome Delivery.

Mouse (Murine) Ubiquilin 2 (UBQLN2) Interaktionspartner

  1. UBQLN2 most evidently bound to HSP70 (zeige HSP70 ELISA Kits)-type chaperones, UBQLN1 (zeige UBQLN1 ELISA Kits) and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice.

  2. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3

  3. UBQLN2 dysregulation in neurons can drive NF-kappaB (zeige NFKB1 ELISA Kits) activation and cytosolic TDP-43 (zeige TARDBP ELISA Kits) aggregation.

  4. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.

  5. results were confirmed by similar findings for ubiquilin-1 (zeige UBQLN1 ELISA Kits) and -2 in human brain tissue sections, where accumulation was observed in huntingtin (zeige HTT ELISA Kits) inclusions

  6. UBQLN2-transfected cells did not show increased starvation-induced cell death.

Ubiquilin 2 (UBQLN2) Antigen-Profil

Beschreibung des Gens

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Genbezeichner und Symbole assoziert mit Ubiquilin 2 (UBQLN2) ELISA Kits

  • ubiquilin 1 (ubqln1) Antikörper
  • ubiquilin 2 (UBQLN2) Antikörper
  • ubiquilin 1 L homeolog (ubqln1.L) Antikörper
  • ubiquilin 2 (Ubqln2) Antikörper
  • ALS15 Antikörper
  • Chap1 Antikörper
  • da41 Antikörper
  • Dsk2 Antikörper
  • HRIHFB2157 Antikörper
  • N4BP4 Antikörper
  • plic-1 Antikörper
  • Plic-2 Antikörper
  • Plic2 Antikörper
  • RGD1563566 Antikörper
  • UBQLN2 Antikörper
  • ubqn Antikörper
  • xdrp1 Antikörper

Bezeichner auf Proteinebene für Ubiquilin 2 (UBQLN2) ELISA Kits

ubiquilin 2 , ubiquilin-2 , Nedd4 binding protein 4 , protein linking IAP with cytoskeleton 2 , ubiquitin-like product Chap1/Dsk2 , Ubiquitin-related protein

394829 Xenopus (Silurana) tropicalis
419078 Gallus gallus
446997 Xenopus laevis
491909 Canis lupus familiaris
539529 Bos taurus
743819 Pan troglodytes
100347089 Oryctolagus cuniculus
29978 Homo sapiens
54609 Mus musculus
317396 Rattus norvegicus
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