Tumor Protein P63 Proteine (TP63)

TP63 encodes a member of the p53 family of transcription factors. Zusätzlich bieten wir Ihnen p63 Antikörper (78) und p63 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TP63 21454 P11983
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.787,14 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
304,76 €
Details

TP63 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, ,
Rat (Rattus)

Am meisten referenzierte p63 Proteine

  1. Human p63 Protein expressed in Wheat germ - ABIN1323400 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

  2. Human p63 Protein expressed in Baculovirus infected Insect Cells - ABIN2005583 : Crum, McKeon: p63 in epithelial survival, germ cell surveillance, and neoplasia. in Annual review of pathology 2010 (PubMed)

Weitere Proteine zu Tumor Protein P63 (TP63) Interaktionspartnern

Horse (Equine) Tumor Protein P63 (TP63) Interaktionspartner

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Mouse (Murine) Tumor Protein P63 (TP63) Interaktionspartner

  1. these results therefore highlight an unanticipated role for p53 (zeige TP53 Proteine) family proteins in a regulatory network that integrates essential Wnt (zeige WNT2 Proteine)-Tcf (zeige HNF4A Proteine) and nodal-Smad (zeige SMAD1 Proteine) inputs.

  2. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (zeige TP53 Proteine) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  3. TGFb3 (zeige TGFB3 Proteine)-induced down-regulation of p63 (zeige CKAP4 Proteine) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

  4. miR-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.

  5. this study shows that CCTalpha (zeige PCYT1A Proteine) is required for antigen-specific, germinal center-derived memory B cells

  6. Taken together, these data show that p63 (zeige CKAP4 Proteine) regulates the self-renewal and differentiation of oesophageal stem cells in humans and mice.

  7. IL-6 (zeige IL6 Proteine)/P-STAT3 (zeige STAT3 Proteine) activation influences p63 (zeige CKAP4 Proteine) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  8. In vivo inhibition of both p63 (zeige CKAP4 Proteine) and p73 (zeige ARHGAP24 Proteine) in combination accelerates tumor regression and increases survival of p53 (zeige TP53 Proteine)-deficient mice.

  9. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (zeige P2RX7 Proteine) (P2X7R (zeige P2RX7 Proteine)) and plays a role in lymphoid neoplasm metastasis.

  10. The data presented here reveal an additional level of interplay between CCT (zeige FLVCR2 Proteine) and actin mediated via gelsolin (zeige GSN Proteine), suggesting that CCT (zeige FLVCR2 Proteine) may influence processes depending on gelsolin (zeige GSN Proteine) activity, such as cell motility.

Human Tumor Protein P63 (TP63) Interaktionspartner

  1. p63 (zeige RPE65 Proteine) is a master regulator in epidermal biology and regulates glycolysis sugar taste in the epidermis.

  2. Anaplastic large cell lymphomas without TP63 rearrangements may express TAp63 isoforms of p63 (zeige RPE65 Proteine) and this expression is associated with extra copies of TP63, probably due to widespread genomic copy number abnormalities rather than focal gains.

  3. Up-regulation of transcription factor DeltaNp63 led to the decline of miR (zeige MLXIP Proteine)-181a expression, resulting in an overexpression of the antiaging protein Sirt1 (zeige SIRT1 Proteine), in CD4 (zeige CD4 Proteine)(+) T cells from HCV-infected individuals. Either reconstituting miR (zeige MLXIP Proteine)-181a or silencing DeltaNp63 or Sirt1 (zeige SIRT1 Proteine) expression in CD4 (zeige CD4 Proteine)(+) T cells led to accelerated T cell senescence.

  4. Knock-down of WWP1 (zeige WWP1 Proteine) abrogates DNA damage-induced down-regulation of DeltaNp63alphaand partially rescues cell apoptosis

  5. The reduction of tumor protein p63 and tumor protein p73 (zeige TP73 Proteine) isoforms, rather than alteration of DeltaN isoform expression, exerted a significant functional repercussion on cell death and proliferation in hepatitis B virus -expressing HepB cells.

  6. TGF-beta1 (zeige TGFB1 Proteine) increased OSCC cell proliferation by upregulating the expression of DeltaNp63 and c-Myc (zeige MYC Proteine) oncogenes. Although the basal OSCC cell proliferation is sustained by activating DeltaNp63, increased induction of c-Myc (zeige MYC Proteine) causes unregulated OSCC cell proliferation.

  7. Results suggest that TP63 rs7631358 G > A and CSF1R (zeige CSF1R Proteine) rs10079250 A > G may affect the risk and prognosis of lung cancer in never-smoking females.

  8. The findings demonstrate that miR (zeige MLXIP Proteine)-203a plays an essential role in keratinocyte proliferation and differentiation caused by extracellular calcium by targeting the SNAI2 (zeige SNAI2 Proteine) and DeltaNp63 genes.

  9. Immunohistochemical detection of thyroid transcription factor 1 (zeige NKX2-1 Proteine), Napsin A (zeige NAPSA Proteine), and P40 (zeige IL9 Proteine) fragment of TP63 can be used in the subclassification of non-small cell lung carcinomas.

  10. CK5 (zeige KRT5 Proteine) and p40 (zeige IL9 Proteine) are good diagnostic markers for squamous cell carcinoma and superior to p63 (zeige RPE65 Proteine)

Zebrafish Tumor Protein P63 (TP63) Interaktionspartner

  1. they unravel essential roles of TAp63 and p53 (zeige TP53 Proteine) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (zeige NOTCH1 Proteine) signalling and caspase 3 (zeige CASP3 Proteine) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (zeige BBC3 Proteine) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (zeige RPS19 Proteine)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (zeige TP53 Proteine) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Xenopus laevis Tumor Protein P63 (TP63) Interaktionspartner

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (zeige BMP4 Proteine).

  3. The role of p63 as a negative Wnt (zeige WNT2 Proteine)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Protein Überblick

Protein Überblick

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Genbezeichner und Symbole assoziert mit Tumor Protein P63 Proteine (TP63)

  • tumor protein p63 (TP63)
  • tumor protein p63 (tp63)
  • tumor protein p63 (LOC100227936)
  • tumor protein p73-like (LOC100393670)
  • tumor protein p73-like (LOC100433100)
  • tumor protein p73-like (LOC100480840)
  • tumor protein p73-like (LOC100496308)
  • tumor protein p73-like (LOC100512967)
  • tumor protein p73-like (LOC100545037)
  • tumor protein p73-like (LOC100577122)
  • tumor protein p73-like (LOC100594205)
  • tumor protein p73-like (LOC100611345)
  • tumor protein p73-like (LOC100624851)
  • tumor protein p73-like (LOC100648488)
  • t-complex protein 1 (Tcp1)
  • transformation related protein 63 (Trp63)
  • tumor protein p63 (Tp63)
  • tumor protein p63-like (LOC100355881)
  • AI462811 Protein
  • AI528772 Protein
  • AIS Protein
  • B(p51A) Protein
  • B(p51B) Protein
  • c-cpn Protein
  • CCT Protein
  • Cct1 Protein
  • Ccta Protein
  • DNp63 Protein
  • EEC3 Protein
  • id:ibd3516 Protein
  • ket Protein
  • LMS Protein
  • NBP Protein
  • np63 Protein
  • OFC8 Protein
  • p40 Protein
  • p51 Protein
  • P51/P63 Protein
  • p53CP Protein
  • P63 Protein
  • p73H Protein
  • p73L Protein
  • RHS Protein
  • SHFM4 Protein
  • Tcp-1 Protein
  • TP53CP Protein
  • TP53L Protein
  • Tp63 Protein
  • tp73l Protein
  • tp73l-A Protein
  • TRic Protein
  • Trp53rp1 Protein
  • TRP63 Protein
  • wu:fc89f04 Protein
  • wu:fk85h07 Protein
  • wu:fk88b02 Protein
  • Xp63 Protein

Bezeichner auf Proteinebene für Tumor Protein P63 Proteine (TP63)

tumor protein p63 , tumor protein 63 , p63 gamma , tumor protein p73-like , tumor protein 63-like , CCT-alpha , T-complex protein 1 subunit alpha , T-complex protein 1 subunit alpha A , T-complex protein 1 subunit alpha B , TCP-1-A , TCP-1-B , TCP-1-alpha , t-complex polypeptide 1 , tailless complex polypeptide 1A , tailless complex polypeptide 1B , transformation-related protein 63 , CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , transformation related protein 63 , tumor protein 63 kDa , delta-Np63 , fc89f04

GENE ID SPEZIES
100059752 Equus caballus
100170632 Oryzias latipes
703997 Macaca mulatta
100048992 Ovis aries
460930 Pan troglodytes
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100393670 Callithrix jacchus
100433100 Pongo abelii
100444448 Pongo abelii
100480840 Ailuropoda melanoleuca
100496308 Xenopus (Silurana) tropicalis
100512967 Sus scrofa
100545037 Meleagris gallopavo
100577122 Apis mellifera
100594205 Nomascus leucogenys
100606847 Nomascus leucogenys
100611345 Pan troglodytes
100624851 Sus scrofa
100648488 Bombus terrestris
21454 Mus musculus
22061 Mus musculus
8626 Homo sapiens
246334 Rattus norvegicus
260407 Danio rerio
373640 Xenopus laevis
374269 Gallus gallus
100732143 Cavia porcellus
100625258 Sus scrofa
488125 Canis lupus familiaris
615335 Bos taurus
101108874 Ovis aries
100355881 Oryctolagus cuniculus
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