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TRAF4 encodes a member of the TNF receptor associated factor (TRAF) family. Zusätzlich bieten wir Ihnen TRAF4 Antikörper (79) und viele weitere Produktgruppen zu diesem Protein an.
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miR (zeige MLXIP Proteine)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 (zeige NCOA1 Proteine) downstream of MEK (zeige MAP2K1 Proteine)-C/EBP (zeige CEBPA Proteine)-mediated leptin (zeige LEP Proteine) and insulin (zeige INS Proteine) signaling, and that insulin (zeige INS Proteine) and/or leptin (zeige LEP Proteine) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (zeige CALR Proteine).
TRAF4 expression is higher in mastocytosis patients with food hypersensitivity in their medical history, while B3GAT1 (zeige B3GAT1 Proteine) expression is lower in mastocytosis patients with insect venom allergy in history
Determined the crystal structure of TRAF (zeige TRAF1 Proteine) domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary.
TRAF4 may promote oral squamous carcinoma cell growth, invasion and migration by Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
There was a significant positive correlation between TRAF2 (zeige TRAF2 Proteine) and TRAF4 expression levels in malignant pleural effusion cells
The TRAF4-ERK (zeige IL17A Proteine)5 is a dominant pathway in human skin squamous cell carcinoma.
Data showed that TRAF4 was highly expressed in non-small cell lung cancer (NSCLC) cells, and miR (zeige MLXIP Proteine)-370 overexpression significantly inhibited its expression. These results suggest that TRAF4 serves as an oncogene (zeige RAB1A Proteine) in NSCLC.
these results suggest that TRAF4 promoted colon cancer cell growth and invasion
Expression of tumor necrosis factor receptor-assicated factor 4 correlates with expression of Girdin and promotes nuclear translocation of Girdin in breast cancer
p70s6k (zeige RPS6KB1 Proteine)/S6 signaling pathway played an important role in the promoting function of TRAF4 on cell proliferation. This work suggests a new direction for understanding the oncogenic function of TRAF4 in breast cancer.
A novel IL-17 (zeige IL17A Proteine) signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 (zeige MAPK7 Proteine) axis.
Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2 (zeige SMURF2 Proteine), to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2 (zeige DAZAP2 Proteine)).
Like IKKalpha (zeige CHUK Proteine), TRAF4 is atypical within its family because it is the only TRAF (zeige TRAF1 Proteine) family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
Report divergent effects of p47(phox) phosphorylation at S303-4 or S379 on tumor necrosis factor-alpha (zeige TNF Proteine) signaling via TRAF4 and MAPK (zeige MAPK1 Proteine) in endothelial cells.
These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination.
enhances TNF-alpha (zeige TNF Proteine) translation
A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.
TRAF4 may play a role in p53 (zeige TP53 Proteine)-mediated proapoptotic signaling in the response to cellular stress
MEKK4 (zeige MAP3K4 Proteine) is the MAPK (zeige MAPK1 Proteine) kinase kinase for TRAF4 regulation of the JNK (zeige MAPK8 Proteine) pathway
cloning of two zebrafish orthologs of the human traf4, traf4a and traf4b; during embryogenesis, traf4b expression is present in a weak ubiquitous manner
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
, RING finger protein 83
, cysteine-rich domain associated with RING and Traf domains protein 1
, cysteine-rich domain associated with ring and TRAF domain
, malignant 62
, metastatic lymph node gene 62 protein
, tumor necrosis receptor-associated factor 4A
, TNF receptor-associated factor 4
, cysteine-rich motif associated to RING and Traf domains protein 1
, LOW QUALITY PROTEIN: TNF receptor-associated factor 4