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The protein encoded by SCG3 is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Zusätzlich bieten wir Ihnen Secretogranin III Kits (16) und Secretogranin III Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SCG3 Primary Antibody für IHC, IHC (p) - ABIN4352445
Leja, Essaghir, Essand, Wester, Oberg, Tötterman, Lloyd, Vasmatzis, Demoulin, Giandomenico: Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009
HBXIP (zeige HBXIP Antikörper) facilitates the proliferation of hepatoma cells by up-regulating SCG3 via E2F1 (zeige E2F1 Antikörper) and miR (zeige MLXIP Antikörper)-509-3p modulation.
SCG3 is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested
SCG3 may be involved in apoptosis signal transduction as a caspase (zeige CASP3 Antikörper) substrate.It may be a pivotal component of the neuroendocrine pathway & play an important role in neuronal communication & neurotransmitter release.
Our data suggest that genetic variations in the FTO (zeige FTO Antikörper), SCG3 and MTMR9 (zeige MTMR9 Antikörper) genes independently influence the risk of metabolic syndrome.
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs (zeige FBN1 Antikörper)) II and III.
SgIII was expressed in 41 of 47 neuroendocrine tumours. The expression of SgIII agreed well with that of CgA (zeige CGA Antikörper), CgB (zeige CGB Antikörper) and SgII (zeige SEMG2 Antikörper), with exceptions of phaeochromocytomas and parathyroid adenomas.
Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion.
these data suggest that SgIII, DMT-1 (zeige DMRT1 Antikörper) and HNP-1 (zeige DEFA1 Antikörper) are implicated in cell-mediated LDL oxidation.
we show by RNA silencing that CPE (zeige CPE Antikörper) and SgIII play a synergistic role in the trafficking of POMC (zeige POMC Antikörper) to granules of the regulated secretory pathway in AtT20 cells
SgIII knockdown impairs intracellular retention of chromogranin A (zeige CHGA Antikörper) and proopiomelanocortin (zeige POMC Antikörper) in AtT-20 cells.
The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits.
SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A (zeige CHGA Antikörper) to secretory granules in pituitary and pancreatic endocrine cells
SgIII and CPE (zeige CPE Antikörper) form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC (zeige POMC Antikörper)-derived peptides are transferred from CPE (zeige CPE Antikörper) to SgIII, and subsequently to CgA (zeige CGA Antikörper).
SCG2 (zeige SCG2 Antikörper), as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules.
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones\; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.