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The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Zusätzlich bieten wir Ihnen SMAD5 Antikörper (111) und SMAD5 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.
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TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.
Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.
Data show that interplay of Smad1 (zeige SMAD1 ELISA Kits)/5 and MAP kinase (zeige MAPK1 ELISA Kits) signaling system (ERK (zeige MAPK1 ELISA Kits) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 (zeige SMAD1 ELISA Kits) and smad9 (zeige SMAD9 ELISA Kits) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.
Functional investigation of a subset of these genes, fgf10a (zeige FGF10 ELISA Kits), tgfb2 (zeige TGFB2 ELISA Kits), pax9 (zeige PAX9 ELISA Kits), and smad5 revealed their necessity in zebrafish palatogenesis.
maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (zeige BMP4 ELISA Kits)/7 signaling to establish the initial dorsoventral asymmetry
Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (zeige SMAD1 ELISA Kits) and Smad5.
Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.
the BMP-2 (zeige BMP2 ELISA Kits)/Smad1 (zeige GARS ELISA Kits)/5/RUNX2 (zeige RUNX2 ELISA Kits) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (zeige BGLAP ELISA Kits) synth
miR (zeige MLXIP ELISA Kits)-23a and miR (zeige MLXIP ELISA Kits)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (zeige FASL ELISA Kits)-Fas (zeige FAS ELISA Kits) pathway
Our findings suggest that suppression of miR (zeige MLXIP ELISA Kits)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (zeige RUNX2 ELISA Kits) signaling axis.
Overexpression of the BMP4 (zeige BMP4 ELISA Kits)/SMAD4 (zeige SMAD4 ELISA Kits)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.
The polycomb group protein L3MBTL1 (zeige L3MBTL1 ELISA Kits) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.
adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (zeige AKT1 ELISA Kits) and SMAD1 (zeige GARS ELISA Kits)/5 during long-period culture.
balance between Smad1 (zeige GARS ELISA Kits)/5- and Smad2 (zeige SMAD2 ELISA Kits)/3-dependent signaling defines the outcome of the effect of TGF-beta (zeige TGFB1 ELISA Kits) on atherosclerosis where Smad1 (zeige GARS ELISA Kits)/5 is responsible for proatherogenic effects
among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (zeige CA8 ELISA Kits).
Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (zeige SMAD4 ELISA Kits)/smad5 pathway.
Inhibiting Smurf1 (zeige SMURF1 ELISA Kits) mediated ubiquitination of Smad1 (zeige GARS ELISA Kits)/5.
We discovered that Smad1 (zeige SMAD1 ELISA Kits)/5/4-Amhr2 (zeige AMHR2 ELISA Kits)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (zeige SMAD1 ELISA Kits)/5/4-Amhr2 (zeige AMHR2 ELISA Kits)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (zeige TGFB1 ELISA Kits)-stimulated BMP R-Smad (zeige SMAD1 ELISA Kits) signaling mechanism in interstitial cells of the developing lung.
Thyroid-specific Smad1 (zeige SMAD1 ELISA Kits) and Smad5 double-knockout (Smad1 (zeige SMAD1 ELISA Kits)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 (zeige SMAD1 ELISA Kits) and Smad5 have overlapping functions to govern hepcidin (zeige HAMP ELISA Kits) transcription. Moreover, erythropoietin (zeige EPO ELISA Kits) and erythroferrone target Smad1 (zeige SMAD1 ELISA Kits)/5 signaling and require Smad1 (zeige SMAD1 ELISA Kits)/5 to suppress hepcidin (zeige HAMP ELISA Kits) expression.
miR (zeige MLXIP ELISA Kits)-106b-5p and miR-17-5p are novel Smad5 regulators.
BetA can enhance in vivo osteogenic potentials of BMP2 (zeige BMP2 ELISA Kits), possibly via stimulating Smad 1 (zeige SMAD1 ELISA Kits)/5/8 and p38 (zeige CRK ELISA Kits) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.
Data show that in R-Smad (zeige SMAD1 ELISA Kits) proteins Smad1 (zeige SMAD1 ELISA Kits);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (zeige SMAD1 ELISA Kits) signaling is dispensable for self-renewal.
Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).
The crystal structure of Smad5-MH1 (zeige SCN5A ELISA Kits) domain in complex with a composite DNA sequence demonstrates that the MH1 (zeige SCN5A ELISA Kits) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (zeige SCN5A ELISA Kits) assembly.
The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (zeige BMP2 ELISA Kits)/Smad1 (zeige SMAD1 ELISA Kits)/5/8 and Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) pathways.
a detailed computational model for TGF-beta (zeige TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 ELISA Kits)/5/8 and Smad2 (zeige SMAD2 ELISA Kits)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 ELISA Kits).
The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.
mothers against decapentaplegic homolog 5
, SMA- and MAD-related protein 5
, SMAD 5
, SMAD family member 5
, mothers against DPP homolog 5
, MAD, mothers against decapentaplegic homolog 5
, SMAD, mothers against DPP homolog 5
, mothers against decapentaplegic, drosophila, homolog of, 5
, MAD homolog 5
, Smad 5
, Mothers against decapentaplegic homolog 5