Retinoschisin 1 Proteine (RS1)

RS1 encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. Zusätzlich bieten wir Ihnen Retinoschisin 1 Antikörper (9) und Retinoschisin 1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RS1 6247 O15537
Maus RS1 RS1 20147 Q9Z1L4
RS1    
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Showing 6 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Takifugu rubripes His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.536,98 €
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
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RS1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Takifugu rubripes

Weitere Proteine zu Retinoschisin 1 (RS1) Interaktionspartnern

Human Retinoschisin 1 (RS1) Interaktionspartner

  1. these findings support distinct mechanisms of pathology for two classes of X-linked retinoschisis -associated mutations in the retinoschisin assembly.

  2. A novel RS1 (97delT) mutation was identified in a Taiwanese family with X-linked retinoschisis (XLRS). This finding expands the RS1 mutation spectrum and may help to further understand the molecular pathogenesis of XLRS.

  3. A novel RS1 (304C > T) mutation in a Taiwanese family with X-linked retinoschisis.

  4. We identified a novel causative mutation of RS1 in a Chinese family with X-linked juvenile retinoschisis.

  5. the disease and p.Arg197Cys mutation of RS1 gene was identified

  6. Sequencing of the RS1 gene identified 16 mutations, nine of which were novel.

  7. Severe RS1 missense changes were associated with a lower ERG b (zeige ERG Proteine)/a ratio than were mild changes in X-linked retinoschisis suggesting the effect of the mutations on protein structure influenced the retinal dysfunction.

  8. Two novel exonic deletions within the RS1 gene locus, are reported.

  9. There is profound phenotypic variability in patients with XLRS. Nonsense, splice-site, or frame-shifting mutations in RS1 consistently caused electronegative bright-flash ERG (zeige ERG Proteine), delayed flicker response, and abnormal PERG

  10. Four novel RS1 gene mutations have been described in male Polish patients with X-linked juvenile retinoschisis.

Mouse (Murine) Retinoschisin 1 (RS1) Interaktionspartner

  1. retinoschisin is a novel regulator of MAP kinase (zeige MAPK1 Proteine) signalling and exerts an anti-apoptotic effect on retinal cells.

  2. Based on this structure, we propose that RS1 couples neighboring membranes together through octamer-octamer contacts, perhaps modulated by interactions with other membrane components.

  3. Changes in Rs1-knockout mice were associated with age related alterations in photoreceptor morphology and transcription factor expression that suggest delayed photoreceptor maturation.

  4. Time line analysis after short-term treatment with dorzolamide failed to show short-, intermediate-, or long-term evidence of structural improvement in Rs1h(-/y) mice.

  5. The results of this study demonstrated that loss of Rs1 gene function has a significant impact on the expression of photoreceptor transcription factor network genes, and morphological and functional defects in young (P21) Rs1-KO mice.

  6. RS1 is needed for preservation of synaptic structures but not synaptogenesis in retinoschisis model.

  7. Data suggest that a CpG island enhancer and two CBRs may act in a combinatorial fashion to fine-tune RS1 transcript levels in the retina.

  8. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 (zeige ATP1A3 Proteine) and ATP1B2 (zeige ATP1B2 Proteine).

  9. Upon Rs1 adsorption, phosphatidylserine and phosphatidylserine-containing mixed lipid bilayers underwent fast and extensive reorganization.

  10. Inactivation of Rs1h suggests a role of retinoschisin in retinal cell layer organization and synaptic structure

Retinoschisin 1 (RS1) Protein Überblick

Protein Überblick

This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

Genbezeichner und Symbole assoziert mit Retinoschisin 1 Proteine (RS1)

  • retinoschisin 1 (RS1)
  • retinoschisin 1 (rs1)
  • retinoschisis (X-linked, juvenile) 1 (human) (Rs1)
  • RS Protein
  • Rs1h Protein
  • tmgc1 Protein
  • Xlrs1 Protein

Bezeichner auf Proteinebene für Retinoschisin 1 Proteine (RS1)

retinoschisis (X-linked, juvenile) 1 , retinoschisin 1 , retinoschisin , retinoschisin-like , X-linked juvenile retinoschisis protein , X-linked juvenile retinoschisis protein homolog , retinoschisis 1 homolog

GENE ID SPEZIES
491762 Canis lupus familiaris
615193 Bos taurus
748866 Pan troglodytes
779332 Xenopus laevis
100124900 Xenopus (Silurana) tropicalis
100126075 Oryctolagus cuniculus
100127441 Sus scrofa
100423325 Macaca mulatta
6247 Homo sapiens
20147 Mus musculus
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