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The protein encoded by RP9 can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . Zusätzlich bieten wir Ihnen Retinitis Pigmentosa 9 (Autosomal Dominant) Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Mutations in a protein target of the Pim-1 (zeige PIM1 Antikörper) kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa
Has a role in pre-mRNA splicing, further evidence that PAP-1 (zeige REG3A Antikörper) is indeed the RP9 gene.
PAP-1 interacted with Prp3p but not Prp31p in human cells and yeast, and the basic region of PAP-1 and the C-terminal region of Prp3p, regions beside spots found in retinitis pigmentosa mutations, were needed for binding
CIR was found to be colocalized with PAP-1 in nuclear speckles.
The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine\\/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene.
Pim-1 kinase associated protein
, pim-1-associated protein
, retinitis pigmentosa 9 protein
, retinitis pigmentosa 9 (autosomal dominant)
, retinitis pigmentosa 9 homolog