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The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Zusätzlich bieten wir Ihnen Prostaglandin E Synthase Antikörper (58) und Prostaglandin E Synthase Kits (21) und viele weitere Produktgruppen zu diesem Protein an.
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C-myc (zeige MYC Proteine) regulates mPGES1 expression by binding to the proximal promoter. C-myc (zeige MYC Proteine) transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.
COX-2 and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis
The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1
These findings support the value of a prognostic and predictive role for mPGES1.
Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2) and microsomal PGE (zeige LIPF Proteine) synthase-1 (mPGES-1) dependent pathway.
Data show that cyclooxygenase2 (COX2)overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (zeige EGR1 Proteine)) in colorectal cancer cell lines.
mPGES-1 is downregulated via EGR1 (zeige EGR1 Proteine) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes
results demonstrate that mPGES-1 is a target gene of defective mismatch repair in human colorectal cancer, with functional consequence
Altered expression of EP2 (zeige SPAG11B Proteine) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (zeige IL1B Proteine) to increase COX-2 and mPGES-1 expression, which results in low PGE2 production
High levels of intra tumoral mPGES-1 is associated with poor prognosis. mPGES-1 after chemotherapy is associated with improved outcomes.
mPGES-1 overexpression prevents Fas (zeige FAS Proteine)-induced hepatocyte apoptosis and liver injury through activation of Akt (zeige AKT1 Proteine) .
The expression of Lcn2 (zeige LCN2 Proteine) and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS (zeige TLR4 Proteine)), indicating that Lcn2 (zeige LCN2 Proteine) mediates LPS (zeige TLR4 Proteine)-induced inflammation. These findings shed light on the role of Lcn2 (zeige LCN2 Proteine) during decidualization.
The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (zeige PGR Proteine).
mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (zeige LDLR Proteine) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.
Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.
Prostacyclin synthase (zeige PTGIS Proteine) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Gas6 (zeige GAS6 Proteine), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.
Vascular mPGES-1 plays a protective role in blood vessels and attenuates rupture of cerebral aneurysms.
Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.
The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (zeige PTGS2 Proteine)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
Prostaglandin E synthase interacts with inducible heat shock protein 70 (zeige HSPA1A Proteine) after heat stress in bovine primary dermal fibroblast cells.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (zeige TNF Proteine)) and Fas (zeige FAS Proteine) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (zeige HSP90AA1 Proteine) (heat shock 90 kD protein 1 alpha).
PGES pathway is responsible for the endometrial production of PGE (zeige LIPF Proteine)(2) in the bovine endometrium during the estrous cycle
This study showed that COX-1 (zeige PTGS1 Proteine) and COX-2 (zeige PTGS2 Proteine) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.
microsomal prostaglandin E synthase-1
, prostaglandin E synthase
, MGST1-like 1
, glutathione S-transferase 1-like 1
, microsomal glutathione S-transferase 1-like 1
, microsomal prostaglandin E synthase 1
, p53-induced apoptosis protein 12
, p53-induced gene 12 protein
, tumor protein p53 inducible protein 12