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Prostaglandin E Synthase Proteine (PTGES)

The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Zusätzlich bieten wir Ihnen Prostaglandin E Synthase Antikörper (58) und Prostaglandin E Synthase Kits (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGES 9536 O14684
PTGES 64292 Q9JM51
Ratte PTGES PTGES 59103  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
594,29 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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PTGES Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Prostaglandin E Synthase (PTGES) Interaktionspartnern

Human Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. C-myc (zeige MYC Proteine) regulates mPGES1 expression by binding to the proximal promoter. C-myc (zeige MYC Proteine) transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.

  2. COX-2 and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis

  3. The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1

  4. These findings support the value of a prognostic and predictive role for mPGES1.

  5. Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2) and microsomal PGE (zeige LIPF Proteine) synthase-1 (mPGES-1) dependent pathway.

  6. Data show that cyclooxygenase2 (COX2)overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (zeige EGR1 Proteine)) in colorectal cancer cell lines.

  7. mPGES-1 is downregulated via EGR1 (zeige EGR1 Proteine) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes

  8. results demonstrate that mPGES-1 is a target gene of defective mismatch repair in human colorectal cancer, with functional consequence

  9. Altered expression of EP2 (zeige SPAG11B Proteine) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (zeige IL1B Proteine) to increase COX-2 and mPGES-1 expression, which results in low PGE2 production

  10. High levels of intra tumoral mPGES-1 is associated with poor prognosis. mPGES-1 after chemotherapy is associated with improved outcomes.

Mouse (Murine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. mPGES-1 overexpression prevents Fas (zeige FAS Proteine)-induced hepatocyte apoptosis and liver injury through activation of Akt (zeige AKT1 Proteine) .

  2. The expression of Lcn2 (zeige LCN2 Proteine) and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS (zeige TLR4 Proteine)), indicating that Lcn2 (zeige LCN2 Proteine) mediates LPS (zeige TLR4 Proteine)-induced inflammation. These findings shed light on the role of Lcn2 (zeige LCN2 Proteine) during decidualization.

  3. The results show that mPges-1 may be a direct downstream target gene of the P4 receptor (zeige PGR Proteine).

  4. mPges-1 depletion modestly increased thrombogenesis in LDL-receptor (zeige LDLR Proteine) knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.

  5. Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.

  6. Prostacyclin synthase (zeige PTGIS Proteine) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  7. Gas6 (zeige GAS6 Proteine), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.

  8. Vascular mPGES-1 plays a protective role in blood vessels and attenuates rupture of cerebral aneurysms.

  9. Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.

  10. The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL.

Cow (Bovine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2 (zeige PTGS2 Proteine)), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.

  2. Prostaglandin E synthase interacts with inducible heat shock protein 70 (zeige HSPA1A Proteine) after heat stress in bovine primary dermal fibroblast cells.

  3. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (zeige TNF Proteine)) and Fas (zeige FAS Proteine) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  4. Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (zeige HSP90AA1 Proteine) (heat shock 90 kD protein 1 alpha).

  5. PGES pathway is responsible for the endometrial production of PGE (zeige LIPF Proteine)(2) in the bovine endometrium during the estrous cycle

Horse (Equine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. This study showed that COX-1 (zeige PTGS1 Proteine) and COX-2 (zeige PTGS2 Proteine) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

Prostaglandin E Synthase (PTGES) Protein Überblick

Protein Überblick

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Genbezeichner und Symbole assoziert mit PTGES

  • prostaglandin E synthase (PTGES)
  • prostaglandin E synthase (ptges)
  • prostaglandin E synthase (Ptges)
  • 2410099E23Rik Protein
  • D2Ertd369e Protein
  • MGC80290 Protein
  • MGST-IV Protein
  • MGST1-L1 Protein
  • MGST1L1 Protein
  • mPGES Protein
  • MPGES-1 Protein
  • Pges Protein
  • PIG12 Protein
  • PP102 Protein
  • PP1294 Protein
  • PTGES Protein
  • TP53I12 Protein

Bezeichner auf Proteinebene für PTGES

microsomal prostaglandin E synthase-1 , prostaglandin E synthase , MGST1-like 1 , glutathione S-transferase 1-like 1 , microsomal glutathione S-transferase 1-like 1 , microsomal prostaglandin E synthase 1 , p53-induced apoptosis protein 12 , p53-induced gene 12 protein , tumor protein p53 inducible protein 12

GENE ID SPEZIES
417193 Gallus gallus
654407 Sus scrofa
446534 Xenopus laevis
473071 Pan troglodytes
9536 Homo sapiens
64292 Mus musculus
59103 Rattus norvegicus
100733230 Cavia porcellus
282019 Bos taurus
480698 Canis lupus familiaris
100034143 Equus caballus
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