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NGB encodes an oxygen-binding protein that is distantly related to members of the globin gene family. Zusätzlich bieten wir Ihnen Neuroglobin Antikörper (85) und Neuroglobin Kits (51) und viele weitere Produktgruppen zu diesem Protein an.
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Human Neuroglobin Protein expressed in Wheat germ - ABIN1312525
Powers: p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy. in Journal of neuropathology and experimental neurology 2006
Ngb expression is limited to the subpopulation of typ (zeige UBXN11 Proteine)e I spiral ganglion cells, those which innervate inner hair cell (zeige UBXN11 Proteine)s, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb.
Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK (zeige PRKAA1 Proteine) signaling.
Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury.
Overexpression of neuroglobin reduced sensorimotor deficits following TBI (zeige TBPL1 Proteine). An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI (zeige TBPL1 Proteine) may improve recovery.
reflect lesser perturbations produced by acute inhalation of combustion smoke in the Ngb overexpressing mouse, suggesting that Ngb mitigates mitochondrial dysfunction and neurotoxicity and raises the threshold of smoke inhalation-induced brain injury
A critical role for neuroglobin is demonstrated via its differential interaction with phosphatase and tensin homolog (PTEN) and Akt during neurite induction.
Neuroglobin overexpression resulted in a significant reduction in infarct volume 24 hours after brain ischemia.
Ngb overexpression can inhibit oxygen-glucose deprivation-induced mitochondria permeability transition opening in primary cultured mouse cortical
CREB (zeige CREB1 Proteine) may also mediate transcriptional regulation of neuroglobin gene.
Ngb deficiency neither affected the level of Melanopsin (zeige OPN4 Proteine) and Tyrosine Hydroxylase (zeige TH Proteine) proteins nor the intactness of PACAP (zeige ADCYAP1 Proteine)-positive retinohypothalamic projections in the suprachiasmatic nucleus.
Knockdown of GATA-2 (zeige GATA2 Proteine) caused NGB (zeige GTPBP4 Proteine) expression to drop dramatically, indicating GATA-2 (zeige GATA2 Proteine) as an essential transcription factor for the activation of NGB (zeige GTPBP4 Proteine) expression via binding to a novel distal regulatory element of NGB (zeige GTPBP4 Proteine).
analysis of how the interaction of hydrogen sulfide (zeige SQRDL Proteine) with human neuroglobin is muted (zeige MUTED Proteine) by a distal ligand
NO oxidation kinetics at physiological NO concentrations. The use of a polarized electrode to efficiently interconvert the ferric (Fe(3+)) and ferrous (Fe(2+)) forms of an immobilized NGB (zeige GTPBP4 Proteine) showed that the disulfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the free ferrous deoxy-NGB (zeige GTPBP4 Proteine), which is the redox active form of the protein in contrast to oxy (zeige GCG Proteine)-NGB (zeige GTPBP4 Proteine).
Taken together, this work support the first evidence that Ngb (zeige GTPBP4 Proteine) can be potentially used as a promising biomarker and target for novel treatment of human glioma
The cochlear nuclei and superior olivary complex (SOC (zeige UBXN11 Proteine)) also express considerable amounts of Ngb (zeige GTPBP4 Proteine). Within the human SOC (zeige UBXN11 Proteine), many medial superior olive neurons, and scattered neurons in the LSO, were Ngb (zeige GTPBP4 Proteine)-immunoreactive
Study characterized the presence of Ngb (zeige GTPBP4 Proteine) in the human cochlea
Data show that the mean peak serum neuroglobin and Nogo-A (zeige RTN4 Proteine) concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after traumatic brain injury (TBI (zeige TBPL1 Proteine)).
Neuroglobin player role in estrogen receptor alpha (zeige ESR1 Proteine)-positive cancer cell viability.
a mechanism for redox control of human Ngb (zeige GTPBP4 Proteine) (hNgb) activity
17beta-estradiol-induced NGB (zeige GTPBP4 Proteine) up-regulation could act as an oxidative stress sensor, which does not oppose to the pro-apoptotic 17beta-estradiol effect in ER beta (zeige ESR2 Proteine)-containing colon cancer cells unless a rise of oxidative stress occurs.
Constitutive expression levels of neuroglobin in neonatal brain cells may explain mild neuronal injury after 60 min. of deep hypothermic circulatory arrest.
Ngb overexpression may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic spinal cord injury
The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
Chimeric Myoglobin (zeige MB Proteine) has a cell-membrane-penetrating activity similar to zebrafish Ngb.
Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin (zeige MB Proteine)-like function of this protein in facilitated oxygen diffusion
both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.
, GTP binding protein 3
, GTP-binding protein NGB
, Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
, chronic renal failure gene protein
, chronic renal failure protein
, nucleolar GTP-binding protein 1