Myocilin Proteine (MYOC)

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. Zusätzlich bieten wir Ihnen Myocilin Antikörper (60) und Myocilin Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MYOC 17926 O70624
MYOC 4653 Q99972
MYOC 81523 Q9R1J4
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Top Myocilin Proteine auf

Showing 10 out of 23 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human His tag Human Myocilin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage

MYOC Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , , , , , , ,
, ,
Rat (Rattus) ,

Weitere Proteine zu Myocilin (MYOC) Interaktionspartnern

Mouse (Murine) Myocilin (MYOC) Interaktionspartner

  1. mutant myocilin induces abnormal ECM (zeige MMRN1 Proteine) accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma.

  2. Mutated myocilin and heterozygous Sod2 (zeige SOD2 Proteine) deficiency act synergistically in a mouse model of open-angle glaucoma

  3. myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 MAPK (zeige MAPK1 Proteine) signaling pathway.

  4. Myocilin binds to ErbB2 (zeige ERBB2 Proteine)/ErbB3 (zeige ERBB3 Proteine), activates these receptors, and affects the downstream PI3K-AKT (zeige AKT1 Proteine) signaling pathway

  5. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38 (zeige CRK Proteine), Erk1/2, and JNK (zeige MAPK8 Proteine) MAP kinase (zeige MAPK1 Proteine) signaling pathways

  6. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin (zeige DMD Proteine) associated protein complex.

  7. The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity.

  8. TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS.

  9. Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma.

  10. Results show that myocilin and gamma-synuclein interact and as a result, myocilin's properties are changed.

Human Myocilin (MYOC) Interaktionspartner

  1. present work reveals that FOXC1 (zeige FOXC1 Proteine) is an important regulator of exocytosis and establishes a new link between FOXC1 (zeige FOXC1 Proteine) and MYOC-associated glaucoma

  2. The four detected MYOC mutations appeared to be associated with morphologic changes in the trabecular meshwork and the underlying pathogenesis of a subtype of familial primary open angle glaucoma.

  3. The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 (zeige B4GALT3 Proteine) are likely responsible for the pathogenesis of Primary Open-angle Glaucoma in this family.

  4. Our findings demonstrated that MYOC cascade genetic testing for POAG allows identification of at-risk individuals at an early stage or even before signs of glaucoma are present. To our knowledge, this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC glaucoma.

  5. regulation by retinoic acid acts through the MYOC promoter which contains a critical cluster of four retinoic acid responsive (zeige GPRC5A Proteine) elements (RAREs), with the RARE-DR2 presenting the strongest effect and binding the RARalpha (zeige RARA Proteine)/RXRalpha (zeige RXRA Proteine) heterodimer.

  6. Five out of 30 families with PCG (16.7%) had disease attributable to CYP1B1 (zeige CYP1B1 Proteine) alterations suggesting that CYP1B1 (zeige CYP1B1 Proteine) is not the major gene causing PCG in Vietnamese unlike in the case of Arab or Romany patients.

  7. The present study provides insight into the genetic or haplotype variants of MYOC and OPTN (zeige OPTN Proteine) genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

  8. Familial linkage studies for primary angle-closure glaucoma have been performed and identified MYOC causative primary angle-closure glaucoma disease

  9. The rate of CYP1B1 (zeige CYP1B1 Proteine) mutations in Lebanese patients with primary congenital glaucoma (PCG) is lower than that reported in other Arab and Middle Eastern populations and suggests other genes are responsible.

  10. Data show that predictive genetic testing for early onset Myocilin glaucoma can facilitate early detection of disease or discharge from routine ophthalmic examinations.

Cow (Bovine) Myocilin (MYOC) Interaktionspartner

  1. endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin

Myocilin (MYOC) Protein Überblick

Protein Überblick

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Genbezeichner und Symbole assoziert mit Myocilin Proteine (MYOC)

  • myocilin (MYOC)
  • myocilin (myoc)
  • myocilin (Myoc)
  • AI957332 Protein
  • GLC1A Protein
  • GPOA Protein
  • JOAG Protein
  • JOAG1 Protein
  • MGC136645 Protein
  • MYOC Protein
  • myocilin Protein
  • Tigr Protein
  • zgc:136645 Protein

Bezeichner auf Proteinebene für Myocilin Proteine (MYOC)

myocilin , trabecular meshwork-induced glucocorticoid response protein , mutated trabecular meshwork-induced glucocorticoid response protein

397046 Sus scrofa
548602 Danio rerio
704406 Macaca mulatta
17926 Mus musculus
4653 Homo sapiens
81523 Rattus norvegicus
281342 Bos taurus
101087632 Felis catus
490344 Canis lupus familiaris
100008897 Oryctolagus cuniculus
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