MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Antikörper (118) und MDS1 and EVI1 Complex Locus Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Ratte MECOM MECOM 294924  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Human
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
Details

Weitere ELISA Kits für MDS1 and EVI1 Complex Locus Interaktionspartner

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. discussion of the role of RUNX1 (zeige RUNX1 ELISA Kits) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (zeige RUNX1 ELISA Kits)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (zeige RUNX1 ELISA Kits) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 ELISA Kits)- and NOTCH1 (zeige NOTCH1 ELISA Kits)-regulated genes, including the MYB (zeige MYB ELISA Kits) and MYC (zeige MYC ELISA Kits) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (zeige ETS1 ELISA Kits)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (zeige RUNX1 ELISA Kits) mutations in acute myeloid leukemia (zeige BCL11A ELISA Kits) and support the notion that RUNX1 (zeige RUNX1 ELISA Kits) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (zeige BCL11A ELISA Kits).

  6. Heterozygous germ line mutations in the RUNX1 (zeige RUNX1 ELISA Kits) gene are responsible genetic events for FPD/AML (zeige RUNX1 ELISA Kits).

  7. Data suggest that RUNX1 (zeige RUNX1 ELISA Kits) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (zeige RUNX1 ELISA Kits), either mutations in RUNX1 (zeige RUNX1 ELISA Kits) gene or variations in expression of RUNX1 (zeige RUNX1 ELISA Kits), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase STUB1 (zeige STUB1 ELISA Kits) is a negative regulator of both RUNX1 (zeige RUNX1 ELISA Kits) and RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 (zeige RUNX1T1 ELISA Kits). Activation of STUB1 (zeige STUB1 ELISA Kits) could be a promising therapeutic strategy for RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 (zeige RUNX1T1 ELISA Kits) leukemia.

  9. The clinical significance of ETV6 (zeige ETV6 ELISA Kits)-RUNX1 (zeige RUNX1 ELISA Kits).

  10. Deliver the necessary promotional drive for the progression of ETV6 (zeige ETV6 ELISA Kits)-RUNX1 (zeige RUNX1 ELISA Kits)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. Gata2 (zeige GATA2 ELISA Kits) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA ELISA Kits) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 ELISA Kits) levels.

  5. Survivin (zeige BIRC5 ELISA Kits) partially regulates HSC (zeige FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (zeige THPO ELISA Kits)/MPL (zeige MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (zeige PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (zeige BAAT ELISA Kits) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL ELISA Kits)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (zeige CEBPB ELISA Kits), liver inhibitory protein (LIP), induced acute myeloid leukemia (zeige BCL11A ELISA Kits) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) Antigen-Profil

Beschreibung des Gens

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (mecom) Antikörper
  • MDS1 and EVI1 complex locus (MECOM) Antikörper
  • MDS1 and EVI1 complex locus (LOC100343228) Antikörper
  • MDS1 and EVI1 complex locus (Mecom) Antikörper
  • runt-related transcription factor 1 (RUNX1) Antikörper
  • AML1 Antikörper
  • AML1-EVI-1 Antikörper
  • AMLCR1 Antikörper
  • CBFA2 Antikörper
  • D630039M04Rik Antikörper
  • EVI-1 Antikörper
  • Evi1 Antikörper
  • im:7140716 Antikörper
  • Jbo Antikörper
  • Mds Antikörper
  • Mds1 Antikörper
  • Mds1-Evi1 Antikörper
  • PEBP2aB Antikörper
  • Prdm3 Antikörper
  • Znfpr1b1 Antikörper

Bezeichner auf Proteinebene für MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPEZIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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