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MDS1 and EVI1 Complex Locus (MECOM) ELISA Kits

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Antikörper (114) und MDS1 and EVI1 Complex Locus Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Anti-Ratte MECOM MECOM 294924  
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Katalog Nr. Reaktivität Sensitivität Bereich Menge Anbieter Lieferzeit Preis Details
96 Tests Anmelden zum Anzeigen 9 bis 12 Tage
788,70 €
96 Tests Anmelden zum Anzeigen 9 bis 12 Tage
788,70 €

Weitere ELISA Kits für MDS1 and EVI1 Complex Locus Interaktionspartner

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 ELISA Kits) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 ELISA Kits) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. the AML1 (zeige RUNX1 ELISA Kits)-ETO (zeige RUNX1T1 ELISA Kits) fusion protein increases the expression of SIRT1 (zeige SIRT1 ELISA Kits), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 ELISA Kits) to activate its transcription in t(8;21) AML (zeige RUNX1 ELISA Kits).

  2. EVI1 transcription is directly regulated by LEF1 (zeige LEF1 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) complex in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A ELISA Kits). Loss of p53 (zeige TP53 ELISA Kits) function as a key regulator for beta-catenin (zeige CTNNB1 ELISA Kits)-EVI1 in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A ELISA Kits).

  3. the Notch (zeige NOTCH1 ELISA Kits) pathway DNA-binding protein (zeige UBE2V1 ELISA Kits) RBP-J (zeige RBPJ ELISA Kits) is the key cellular factor hijacked by EBNA2 to direct activation of RUNX1 (zeige RUNX1 ELISA Kits) transcription via upstream super-enhancers.

  4. revealed more than 170 NFAT (zeige NFATC1 ELISA Kits)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (zeige NFATC1 ELISA Kits) and NFATc2 (zeige NFAT1 ELISA Kits) in T cells, such as Raptor (zeige RPTOR ELISA Kits), CHEK1 (zeige CHEK1 ELISA Kits), CREB1 (zeige CREB1 ELISA Kits), RUNX1 (zeige RUNX1 ELISA Kits), SATB1 (zeige SATB1 ELISA Kits), Ikaros (zeige IKZF1 ELISA Kits), and Helios (zeige ZNFN1A2 ELISA Kits).

  5. we demonstrated that miR (zeige MLXIP ELISA Kits)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1) mRNA is a direct target of miR (zeige MLXIP ELISA Kits)-22 and MECOM (EVI1) functions as a negative regulator in the differentiation.The miR (zeige MLXIP ELISA Kits)-22-mediated MECOM degradation increased c-Jun (zeige JUN ELISA Kits) but decreased GATA2 (zeige GATA2 ELISA Kits) expression, which results in increased interaction between c-Jun (zeige JUN ELISA Kits) and PU.1

  6. Data show that the interaction between aptamer and AML1 (RUNX1 (zeige RUNX1 ELISA Kits)) protein DNA-binding domain known as the Runt (zeige RUNX1 ELISA Kits) domain (RD) is driven by a large enthalpy change.

  7. Results establish the oncogenic contributions of EVI1 in ER- and HER2 (zeige ERBB2 ELISA Kits)-negative subsets of breast cancer.

  8. A feedback circuitry involving miR (zeige MLXIP ELISA Kits)-9-1 and RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 (zeige RUNX1T1 ELISA Kits).

  9. The requirement for Runx1 (zeige RUNX1 ELISA Kits) in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system.

  10. RUNX1 (zeige RUNX1 ELISA Kits) is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 (zeige RUNX1 ELISA Kits) cause familial platelet disorder with associated myeloid malignancies.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA ELISA Kits) from EVI1-induced suppression.

  2. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 ELISA Kits), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 ELISA Kits) levels.

  3. Survivin (zeige BIRC5 ELISA Kits) partially regulates HSC (zeige FUT1 ELISA Kits) function by modulating the Evi-1 transcription factor and its downstream targets

  4. Thrombopoietin (zeige THPO ELISA Kits)/MPL (zeige MPL ELISA Kits) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  5. Prdm16 (zeige PRDM16 ELISA Kits) and Prdm3 control postnatal BAT (zeige BAAT ELISA Kits) identity and function.

  6. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  7. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL ELISA Kits)) fusion protein (MFP) leukemia

  8. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (zeige CEBPB ELISA Kits), liver inhibitory protein (LIP), induced acute myeloid leukemia (zeige BCL11A ELISA Kits) with short latencies in a mouse bone marow transplantation model.

  9. Transient Evi1 transfection inhibited TGF-beta (zeige TGFB1 ELISA Kits)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (zeige TGFB1 ELISA Kits) in MC-26 (zeige Glycam1 ELISA Kits) mouse colon cancer cells.

  10. Evi1 is a key regulator of adipogenic competency

MDS1 and EVI1 Complex Locus (MECOM) Antigen-Profil

Beschreibung des Gens

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (mecom) Antikörper
  • MDS1 and EVI1 complex locus (MECOM) Antikörper
  • MDS1 and EVI1 complex locus (LOC100343228) Antikörper
  • MDS1 and EVI1 complex locus (Mecom) Antikörper
  • runt-related transcription factor 1 (RUNX1) Antikörper
  • AML1 Antikörper
  • AML1-EVI-1 Antikörper
  • AMLCR1 Antikörper
  • CBFA2 Antikörper
  • D630039M04Rik Antikörper
  • EVI-1 Antikörper
  • Evi1 Antikörper
  • im:7140716 Antikörper
  • Jbo Antikörper
  • Mds Antikörper
  • Mds1 Antikörper
  • Mds1-Evi1 Antikörper
  • PEBP2aB Antikörper
  • Prdm3 Antikörper
  • Znfpr1b1 Antikörper

Bezeichner auf Proteinebene für MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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