Hematopoietic Cell Signal Transducer Proteine (HCST)

HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. Zusätzlich bieten wir Ihnen HCST Antikörper (31) und HCST Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HCST 10870 Q9UBK5
HCST 23900 Q9QUJ0
Ratte HCST HCST 474146 Q6X9T8
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HCST Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Hematopoietic Cell Signal Transducer (HCST) Interaktionspartnern

Zebrafish Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. The structure of the adaptor protein dap10 has been identified in the zebrafish genome.

Human Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. These results suggest that NKG2D (zeige KLRK1 Proteine)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.

  2. findings indicate that the functional interaction between RAGE (zeige AGER Proteine) and DAP10 coordinately regulates S100A8 (zeige S100A8 Proteine)/A9-mediated survival and/or apoptotic response of keratinocytes

  3. TGF-beta1 (zeige TGFB1 Proteine) may reduce the expression of NKG2D (zeige KLRK1 Proteine)/DAP10 and 2B4 (zeige CD244 Proteine)/SAPin patients with hepatitis B.

  4. HMBOX1 (zeige HMBOX1 Proteine) negatively regulates the expression of NKG2D (zeige KLRK1 Proteine) and the activation of the NKG2D (zeige KLRK1 Proteine)/DAP10 signaling pathway in NK cells.

  5. Other gamma(c) cytokines act similarly to IL-2 (zeige IL2 Proteine) in up-regulating DAP10 expression and NKG2D (zeige KLRK1 Proteine)-DAP10 surface expression.

  6. TGF-BETA1 (zeige TGFB1 Proteine) down-modulates surface NKG2D (zeige KLRK1 Proteine) expression by controlling the transcriptional and translational levels of DAP10.

  7. A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12 (zeige TYROBP Proteine), not the DAP10 adaptor protein.

  8. NKG2D (zeige KLRK1 Proteine)-DAP10 triggers human NK cell-mediated killing via a Syk (zeige SYK Proteine)-independent regulatory pathway.

  9. both activated and expanded CD8 (zeige CD8A Proteine)+ T cells and NK cells use DAP10 for cytolysis

  10. Downstream targets of DAP10 and DAP12 (zeige TYROBP Proteine) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (zeige TYROBP Proteine) dramatically reduces their lytic capacity.

Mouse (Murine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

  1. Rat and mouse CD94 (zeige KLRD1 Proteine)/NKG2C (zeige KLRC2 Proteine) heterodimers bind efficiently to both DAP12 (zeige TYROBP Proteine) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (zeige KLRD1 Proteine).

  2. contributes to CD8 (zeige CD8A Proteine)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

  3. demonstrate a previously uncharacterized interaction of SHIP1 (zeige INPP5D Proteine) with DAP12 (zeige TYROBP Proteine) that limits TREM2 (zeige TREM2 Proteine)- and DAP12 (zeige TYROBP Proteine)-dependent signaling and identify a mechanism through which SHIP1 (zeige INPP5D Proteine) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K

  4. selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (zeige KLRK1 Proteine)

  5. Differential requirements for Vav (zeige VAV1 Proteine) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

  6. The importance of Fcgr3 (zeige CD16 Proteine)/Cd3z (zeige CD247 Proteine), Hcst, and Tyrobp (zeige TYROBP Proteine) in the activation of NK cells in the uterus of pregnant mice is reported.

  7. Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (zeige GRB10 Proteine) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.

  8. DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.

  9. improved rejection of B16 melanomas in DAP10-deficient mice

  10. these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells.

Cow (Bovine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

HCST Protein Überblick

Protein Überblick

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit HCST

  • hematopoietic cell signal transducer (HCST)
  • hematopoietic cell signal transducer (hcst)
  • hematopoietic cell signal transducer (Hcst)
  • Dap10 Protein
  • HCST Protein
  • KAP10 Protein
  • PIK3AP Protein

Bezeichner auf Proteinebene für HCST

hematopoietic cell signal transducer , dap10 , DNAX-activation protein 10 , kinase assoc pro of ~10kDa , kinase assoc protein , membrane protein DAP10 , phosphoinositide-3-kinase adaptor protein , transmembrane adapter protein KAP10 , putative membrane adaptor molecule , immunoreceptor DAP10

GENE ID SPEZIES
612627 Canis lupus familiaris
748082 Pan troglodytes
100101460 Danio rerio
10870 Homo sapiens
23900 Mus musculus
474146 Rattus norvegicus
767892 Bos taurus
397267 Sus scrofa
574152 Macaca mulatta
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