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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Zusätzlich bieten wir Ihnen EWSR1 Antikörper (153) und EWSR1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Gnai1 (zeige GNAI1 ELISA Kits) function is impaired in the spinal cord of Ews/Ewsr1 KO mice
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (zeige BMP2 ELISA Kits) and BMP4 (zeige BMP4 ELISA Kits) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (zeige PPARGC1A ELISA Kits) protein stability
both Etv1 (zeige ETV1 ELISA Kits) and Ewsr1 were necessary for Fgf10 (zeige FGF10 ELISA Kits) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (zeige COL4A1 ELISA Kits) and CTGF (zeige CTGF ELISA Kits) via a Drosha (zeige DROSHA ELISA Kits)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (zeige AFT1 ELISA Kits) resulted in the development of EWS/ATF1 (zeige AFT1 ELISA Kits)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (zeige AFT1 ELISA Kits)-driven transformation.
Mutation of the EWS gene modulates Sox9 (zeige SOX9 ELISA Kits) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (zeige FLI1 ELISA Kits) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1-FLI1 (zeige FLI1 ELISA Kits) and its effectors has produced promising results.
data suggest EWS/FLI (zeige FLII ELISA Kits) binds to "promoter-like" and "enhancer-like" microsatellites to mediate activation and repression of target genes through different regulatory mechanisms
four oncogenic ETS (zeige ETS1 ELISA Kits) (ERG (zeige ERG ELISA Kits), ETV1 (zeige ETV1 ELISA Kits), ETV4 (zeige ETV4 ELISA Kits), and ETV5), and no other ETS (zeige ETS1 ELISA Kits), interact with the Ewing's sarcoma breakpoint protein, EWS.
As spontaneous fluctuations in EWS-FLI1 (zeige FLI1 ELISA Kits) levels of Ewing sarcoma cells in vitro and in vivo, associated with a switch between a proliferative, non-migratory EWS-FLI1 (zeige FLI1 ELISA Kits)-high and a non-proliferative highly migratory EWS-FLI1 (zeige FLI1 ELISA Kits)-low state, were recently described, our data provide a mechanistic basis for the underlying EWS-FLI1 (zeige FLI1 ELISA Kits)-dependent reversible cytoskeletal reprogramming of Ewing sarcoma cells.
Fusion of short fragments of EWSR1 to FLI1 (zeige FLI1 ELISA Kits) is sufficient to recapitulate BAF (zeige BANF1 ELISA Kits) complex retargeting and EWS-FLI1 (zeige FLI1 ELISA Kits) activities; studies thus demonstrate that the physical properties of prion (zeige PRNP ELISA Kits)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (zeige AFT1 ELISA Kits) gene fusion.
Results expand the spectrum of tumor types harboring EWSR1/FUS (zeige FUS ELISA Kits)-ATF1 (zeige AFT1 ELISA Kits) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.
papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement
The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (zeige FLI1 ELISA Kits) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.
Aggregation of FET proteins FUS, EWSR1, and TAF15 mediate a pathological change in amyotrophic lateral sclerosis. (Review)
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene