Ewing Sarcoma Breakpoint Region 1 (EWSR1) ELISA Kits

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Zusätzlich bieten wir Ihnen EWSR1 Antikörper (153) und EWSR1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
Anti-Ratte EWSR1 EWSR1 289752  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für EWSR1 Interaktionspartner

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. Gnai1 (zeige GNAI1 ELISA Kits) function is impaired in the spinal cord of Ews/Ewsr1 KO mice

  2. EWS is normally O-GlcNAc glycosylated in the brain.

  3. glycosylation of EWS protein

  4. EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  5. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (zeige BMP2 ELISA Kits) and BMP4 (zeige BMP4 ELISA Kits) expression.

  6. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (zeige PPARGC1A ELISA Kits) protein stability

  7. both Etv1 (zeige ETV1 ELISA Kits) and Ewsr1 were necessary for Fgf10 (zeige FGF10 ELISA Kits) expression and elongation of the limb bud.

  8. EWS is involved in post-transcriptional regulation of Col4a1 (zeige COL4A1 ELISA Kits) and CTGF (zeige CTGF ELISA Kits) via a Drosha (zeige DROSHA ELISA Kits)-miRNA-dependent pathway.

  9. These results demonstrate that EWS is essential for early brown fat lineage determination.

  10. Forced expression of EWS/ATF1 (zeige AFT1 ELISA Kits) resulted in the development of EWS/ATF1 (zeige AFT1 ELISA Kits)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (zeige AFT1 ELISA Kits)-driven transformation.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. Mutation of the EWS gene modulates Sox9 (zeige SOX9 ELISA Kits) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (zeige FLI1 ELISA Kits) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1-FLI1 (zeige FLI1 ELISA Kits) and its effectors has produced promising results.

  2. data suggest EWS/FLI (zeige FLII ELISA Kits) binds to "promoter-like" and "enhancer-like" microsatellites to mediate activation and repression of target genes through different regulatory mechanisms

  3. four oncogenic ETS (zeige ETS1 ELISA Kits) (ERG (zeige ERG ELISA Kits), ETV1 (zeige ETV1 ELISA Kits), ETV4 (zeige ETV4 ELISA Kits), and ETV5), and no other ETS (zeige ETS1 ELISA Kits), interact with the Ewing's sarcoma breakpoint protein, EWS.

  4. As spontaneous fluctuations in EWS-FLI1 (zeige FLI1 ELISA Kits) levels of Ewing sarcoma cells in vitro and in vivo, associated with a switch between a proliferative, non-migratory EWS-FLI1 (zeige FLI1 ELISA Kits)-high and a non-proliferative highly migratory EWS-FLI1 (zeige FLI1 ELISA Kits)-low state, were recently described, our data provide a mechanistic basis for the underlying EWS-FLI1 (zeige FLI1 ELISA Kits)-dependent reversible cytoskeletal reprogramming of Ewing sarcoma cells.

  5. Fusion of short fragments of EWSR1 to FLI1 (zeige FLI1 ELISA Kits) is sufficient to recapitulate BAF (zeige BANF1 ELISA Kits) complex retargeting and EWS-FLI1 (zeige FLI1 ELISA Kits) activities; studies thus demonstrate that the physical properties of prion (zeige PRNP ELISA Kits)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.

  6. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (zeige AFT1 ELISA Kits) gene fusion.

  7. Results expand the spectrum of tumor types harboring EWSR1/FUS (zeige FUS ELISA Kits)-ATF1 (zeige AFT1 ELISA Kits) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  8. papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement

  9. The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (zeige FLI1 ELISA Kits) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.

  10. Aggregation of FET proteins FUS, EWSR1, and TAF15 mediate a pathological change in amyotrophic lateral sclerosis. (Review)

EWSR1 Antigen-Profil

Beschreibung des Gens

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Genbezeichner und Symbole assoziert mit EWSR1

  • EWS RNA binding protein 1 (EWSR1) Antikörper
  • EWS RNA binding protein 1 (ewsr1) Antikörper
  • Ewing sarcoma breakpoint region 1 (Ewsr1) Antikörper
  • EWS RNA-binding protein 1a (ewsr1a) Antikörper
  • EWS RNA-binding protein 1 (Ewsr1) Antikörper
  • AU018891 Antikörper
  • bK984G1.4 Antikörper
  • DKFZp459K1116 Antikörper
  • Ews Antikörper
  • Ewsh Antikörper
  • EWSR1 Antikörper
  • fc04c01 Antikörper
  • wu:fc04c01 Antikörper

Bezeichner auf Proteinebene für EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

748264 Pan troglodytes
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100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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