DNA (Cytosine-5-)-Methyltransferase 3 beta Proteine (DNMT3B)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3B Antikörper (133) und DNMT3B Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DNMT3B 1789 Q9UBC3
Ratte DNMT3B DNMT3B 444985  
DNMT3B 13436 O88509
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Top DNMT3B Proteine auf antikoerper-online.de

Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Maus T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage

DNMT3B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) ,

Am meisten referenzierte DNMT3B Proteine

  1. Human DNMT3B Protein expressed in HEK-293 Cells - ABIN2719618 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

Weitere Proteine zu DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartnern

Zebrafish DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. dnmt7 specifically methylates no tail gene in the genome

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Proteine) content are rather a function of time, and not a genetic component.

Human DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. found association between DNMT3B rs2424913 in T allele carriers with Parkinson's disease

  2. H19 (zeige NCKAP1 Proteine) might function as ceRNA (competing endogenous RNA) for miR (zeige MLXIP Proteine)-29b-3p and relieve the suppression for DNMT3B, which led to EMT (zeige ITK Proteine) and metastasis of bladder cancer (BC). Our findings highlight a novel mechanism of H19 (zeige NCKAP1 Proteine) in progression of BC and provide H19 (zeige NCKAP1 Proteine)/miR (zeige MLXIP Proteine)-29b-3p/DNMT3B axis as a promising therapeutic target for BC.

  3. DNMT1 (zeige DNMT1 Proteine) up-regulation induced by IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) signaling was indispensable for IL-6 (zeige IL6 Proteine)-mediated hepaCAM (zeige HEPACAM Proteine) loss in renal cell carcinoma (zeige MOK Proteine) (RCC (zeige XRCC1 Proteine)) cell lines ACHN (zeige LARP6 Proteine) and 769-P, while DNMT3b up-regulation was crucial for hepaCAM (zeige HEPACAM Proteine) loss in A498.

  4. A Methylated DNA Quantification Kit was used to quantify global DNA methylation (zeige HELLS Proteine), and single nucleotide polymorphisms (SNPs) in DNMT3A (zeige DNMT3A Proteine) (rs36012910, rs1550117, and R882) and DNMT3B (rs1569686, rs2424909, and rs2424913) were identified using the restriction fragment length polymorphism method

  5. A novel homozygous missense mutation, Ala585Thr, was found in DNMT3B.

  6. Definitive diagnosis should be done using metaphase analysis to identify centromeric instability and/or ICF disease gene mutations analysis. Bilateral VUR may occur in ICF patients with homozygous DNMT3B mutations in early childhood. Renal ultrasonography should be included in ICF1 patients for the screening of congenital anomalies.

  7. DNMT 3B was upregulated in invasive subclones and exerted on influence of E-cad gene methylation.

  8. Transduction of miR (zeige MLXIP Proteine)-339 and miR (zeige MLXIP Proteine)-766 expressing viruses into colon cancer cell lines (SW480 and HCT116) decreased DNMT3B expression (1.5, 3-fold) and (3, 4-fold), respectively. In addition, DNA methylation (zeige HELLS Proteine) of some tumor suppressor genes decreased.

  9. Immunodeficiency, centromere instability and facial anomalies syndrome specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing.

  10. nickel exposure results in DNMT3b induction and MEG3 (zeige FAM129B Proteine) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (zeige JUN Proteine) and in turn increasing c-Jun (zeige JUN Proteine) inhibition of PHLPP1 transcription, leading to the Akt (zeige AKT1 Proteine)/p70S6K (zeige RPS6KB1 Proteine)/S6 axis activation, and HIF-1alpha (zeige HIF1A Proteine) protein translation, as well as malignant transformation of human bronchial epithelial cells.

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Proteine) and E-CADHERIN (zeige CDH1 Proteine), and the pluripotency markers, DNMT3B and CRIPTO (zeige TDGF1 Proteine).

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.

  2. The expression levels of DNMT3a (zeige DNMT3A Proteine) and DNMT3b were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaktionspartner

  1. a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.

  2. Together, this study described the regulation of Chk2 (zeige CHEK2 Proteine) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (zeige CHEK2 Proteine) during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  3. in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation

  4. three DNA methyltransferases, Dnmt1 (zeige DNMT1 Proteine), Dnmt3a (zeige DNMT3A Proteine), and Dnmt3b, have been identified. Dnmt3a (zeige DNMT3A Proteine) and Dnmt3b are responsible for establishing DNA methylation (zeige HELLS Proteine) patterns produced through their de novo-type DNA methylation (zeige HELLS Proteine) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 Proteine)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS Proteine)

  5. While lens epithelial cell survival requires DNMT1 (zeige DNMT1 Proteine), morphologically normal lenses develop in the absence of both DNMT3A (zeige DNMT3A Proteine) and DNMT3B.

  6. Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.

  7. a miR (zeige MLXIP Proteine)-125b-DNMT3b-p53 (zeige TP53 Proteine) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.

  8. miR-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b and SET1A expression in hepatic stellate cells.

  9. Loss of DNMT3B results in hypomethylation of the miR-196b promoter and increased miR-196b expression, which directly targets the mTORC2 component Rictor.

  10. The findings define PRMT7 (zeige PRMT7 Proteine) as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity.

DNMT3B Protein Überblick

Protein Überblick

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Genbezeichner und Symbole assoziert mit DNMT3B

  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 (dnmt3bb.1)
  • DNA methyltransferase 3 beta (DNMT3B)
  • microtubule associated protein RP/EB family member 1 (MAPRE1)
  • DNA methyltransferase 3 beta (dnmt3b)
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a (dnmt3ba)
  • DNA methyltransferase 3 beta (Dnmt3b)
  • DNA methyltransferase 3B (Dnmt3b)
  • cb91 Protein
  • cb633 Protein
  • DNMT3B Protein
  • dnmt3bl Protein
  • dnmt7 Protein
  • ICF Protein
  • ICF1 Protein
  • LOC100218113 Protein
  • M.HsaIIIB Protein
  • MmuIIIB Protein
  • sb:cb91 Protein
  • wu:fb16h07 Protein

Bezeichner auf Proteinebene für DNMT3B

DNA (cytosine-5)-methyltransferase 3B , DNA (cytosine-5-)-methyltransferase 3 beta , DNA cytosine-5 methyltransferase 3 beta , DNA (cytosine-5)-methyltransferase 3B-like , DNA methyl transferase beta , DNA methyltransferase 3B , DNA MTase HsaIIIB , DNA methyltransferase HsaIIIB , DNA (cytosine-5-)-methyltransferase 3 beta, like , DNA (cytosine-5-)-methyltransferase 7 , fb16h07 , DNA MTase MmuIIIB , DNA methyltransferase MmuIIIB

317744 Danio rerio
458174 Pan troglodytes
711553 Macaca mulatta
100053900 Equus caballus
100218113 Taeniopygia guttata
100412936 Callithrix jacchus
100459992 Pongo abelii
100466728 Ailuropoda melanoleuca
100500777 Ovis aries
100598378 Nomascus leucogenys
100528060 Anolis carolinensis
1789 Homo sapiens
321084 Danio rerio
419287 Gallus gallus
100302109 Sus scrofa
353354 Bos taurus
444985 Rattus norvegicus
13436 Mus musculus
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