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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Zusätzlich bieten wir Ihnen Cystathionine-beta-Synthase Antikörper (123) und Cystathionine-beta-Synthase Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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Human CBS ELISA Kit für Sandwich ELISA - ABIN456995
Sun, Sun, Li, Pan, Xie, Wang, Zhang: Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide. in Chinese medical journal 2014
showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (zeige CTH ELISA Kits) slightly ameliorates the outcome of LPS (zeige TLR4 ELISA Kits)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (zeige CTH ELISA Kits) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 and Tet2 (zeige TET2 ELISA Kits) expression, which leads to hypermethylation of Foxp3 (zeige FOXP3 ELISA Kits), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha (zeige PPARGC1A ELISA Kits) specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (zeige IL10 ELISA Kits) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
Brain of mice heterozygous for Cbs displays overexpression of DYR (zeige DHFR ELISA Kits) kinase and SAH (zeige ACSM3 ELISA Kits) hydrolase.
Uterine artery hydrogen sulfide production is augmented with endothelium and smooth muscle CBS upregulation, contributing to uterine artery vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.
Common polymorphisms in MTHFR (zeige MTHFR ELISA Kits), methionine synthase (zeige MTR ELISA Kits) and cystathione beta lyase genes have no role in premature acute myocardial infarction in Pakistani population.
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.
The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.
There is no ordinary conjunction between human CBS and severe sepsis/septic shock, but CBS genotypes are involved in disease susceptibility.
Oligomeric status of human cystathionine beta-synthase modulates AdoMet (zeige MAT1A ELISA Kits) binding.
Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR (zeige MTHFR ELISA Kits); C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.
results indicate that binding of SAM (zeige TTN ELISA Kits) to regulatory and stabilizing sites in CBS may have evolved to display an exquisite thermodynamic and structural specificity towards SAM (zeige TTN ELISA Kits) as well as the ability to transduce the allosteric signal responsible for CBS activation.
CBS 844ins68 polymorphisms were not associated with Oral squamous cell carcinoma risk in southeastern Brazilians.
These findings indicate that greater synthesis of phosphatidylcholine (zeige SGMS1 ELISA Kits) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase