anti-Cyclin T1 (CCNT1) Antikörper

CCNT1 encodes a member of the highly conserved cyclin C subfamily. Zusätzlich bieten wir Ihnen Cyclin T1 Kits (12) und Cyclin T1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CCNT1 904 O60563
CCNT1 12455 Q9QWV9
CCNT1 315291  
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-CCNT1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>721_B cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB <span>CCNT1 Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.</span> <span>CCNT1 Antibody (Center) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow).</span> 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert FACS, WB CCNT1 Antibody (Center) (ABIN654626) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert IHC (p), WB   100 μg Anmelden zum Anzeigen 4 bis 6 Tage
Human Kaninchen Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert EIA, IHC (fro), IHC (p), IP, WB   0.1 mL Anmelden zum Anzeigen 12 bis 15 Tage
Human Kaninchen Unkonjugiert IP, IHC, ELISA, WB Amino acids are numbered on the bottom of each protein. The cyclin box is indicated. Human cyclins T2a and T2b have 642 amino acids in common but different carboxyl termini (black boxes). Background Information:  Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. Tat stimulates human HIV-1 viral transcription elongation.  This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb.   P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev.  Cyclin T1 is an exceptionally large cyclin and is therefore a candidate for interactions with regulatory proteins. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert IHC (p), IP, ELISA, WB Human Skin (formalin-fixed, paraffin-embedded) stained with CCNT1 antibody ABIN218501 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 16 Days

CCNT1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Cyclin T1 Antikörper

  1. Human Polyclonal Cyclin T1 Primary Antibody für EIA, FACS - ABIN951765 : Moiola, De Luca, Gardner, Vazquez, De Siervi: Cyclin T1 overexpression induces malignant transformation and tumor growth. in Cell cycle (Georgetown, Tex.) 2010 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal Cyclin T1 Primary Antibody für WB - ABIN2792158 : Sun, Zheng, Zhao, Lee, Goldstein: Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide in Journal of virology 2008 (PubMed)

Weitere Antikörper gegen Cyclin T1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Cyclin T1 (CCNT1) Interaktionspartner

  1. We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb (zeige CDK9 Antikörper), SEC and Mediator levels in Drosophila embryos.

  2. following P-TEFb (zeige CDK9 Antikörper) inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated

Human Cyclin T1 (CCNT1) Interaktionspartner

  1. The TAR (zeige RBM8A Antikörper) central loop contacts the CycT1 Tat (zeige TAT Antikörper)-TAR (zeige RBM8A Antikörper) recognition motif (TRM) and the second Tat (zeige TAT Antikörper) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 (zeige AFF4 Antikörper) helix 2 is stabilized in the TAR (zeige RBM8A Antikörper) complex despite not touching the RNA, explaining how it enhances TAR (zeige RBM8A Antikörper) binding to the SEC 50-fold.

  2. Quantitative measurement of the molecular interactions among Tat (zeige TAT Antikörper), CycT1 and CDK9 (zeige CDK9 Antikörper) has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb (zeige TEF Antikörper) complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.

  3. the introduction of HIV-1 Tat (zeige TAT Antikörper) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9 (zeige CDK9 Antikörper)/cyclin T1 complex

  4. AFF4 (zeige AFF4 Antikörper) is positioned to make unexpected direct contacts with HIV Tat (zeige TAT Antikörper), and Tat (zeige TAT Antikörper) enhances P-TEFb/CCNT1 affinity for AFF4 (zeige AFF4 Antikörper).

  5. Plk1 (zeige PLK1 Antikörper) negatively regulates the RNA polymerase II-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 (zeige CDK9 Antikörper) complex.

  6. The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.

  7. the release of P-TEFb from the 7SK snRNP (zeige LSM2 Antikörper) led to increased synthesis of HEXIM1 (zeige HEXIM1 Antikörper) but not HEXIM2 (zeige HEXIM2 Antikörper)

  8. All of the hCD4/R5/cT1 (zeige CTF1 Antikörper) mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone

  9. positive transcription elongation factor b (P-TEFb (zeige CDK9 Antikörper), made of CDK9 (zeige CDK9 Antikörper) and CycT1) is released from its inhibitory complex by histone deacetylase (zeige HDAC1 Antikörper) inhibitors, which also activate HIV transcription

  10. CYCT1b is a newly identified cyclin T1 splice variant whose expression leads to direct inhibition of TAT (zeige TAT Antikörper)-transactivated transcription of the HIV-1 LTR promoter

Mouse (Murine) Cyclin T1 (CCNT1) Interaktionspartner

  1. Data show that the minimal 90-amino acid AF9 (zeige MLLT3 Antikörper) fragment in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1 (zeige DOT1L Antikörper).

  2. Data show that the CDK9 (zeige CDK9 Antikörper) and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 (zeige CDK9 Antikörper) is essential for embryonic genome activation in the mouse.

  3. Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 (zeige E2F1 Antikörper) pathway.

  4. CDK9 (zeige CDK9 Antikörper) has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

  5. P-TEFb is a key mediator of Myc (zeige MYC Antikörper) activated transcription by stimulating elongation

  6. Tat (zeige TAT Antikörper) and trans-activation-responsive (TAR (zeige RBM8A Antikörper)) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1 (zeige SP1 Antikörper).

  7. cyclin T1 binds with granulin (zeige GRN Antikörper) to inhibit transcription

  8. location of the cyclin T1 gene regulatory elements is male germ cell-specific

  9. These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.

  10. knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 (zeige CD4 Antikörper) expression

Cyclin T1 (CCNT1) Antigen-Profil

Protein Überblick

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Cyclin T1 (CCNT1) Antikörper

  • Cyclin T (CycT) Antikörper
  • cyclin T1 (CCNT1) Antikörper
  • cyclin T1 (ccnt1) Antikörper
  • cyclin T1 (Ccnt1) Antikörper
  • cyclin T1 L homeolog (ccnt1.L) Antikörper
  • 2810478G24Rik Antikörper
  • AI115585 Antikörper
  • anon-74EFc Antikörper
  • CCNT Antikörper
  • CG6292 Antikörper
  • Cyclin-T1 Antikörper
  • CycT1 Antikörper
  • Dmcyclin T Antikörper
  • Dmel\\CG6292 Antikörper
  • dT Antikörper
  • fi75b02 Antikörper
  • HIVE1 Antikörper
  • ORE-14 Antikörper
  • P-TEFb Antikörper
  • p124 Antikörper
  • si:dkey-18f23.10 Antikörper
  • wu:fi75b02 Antikörper

Bezeichner auf Proteinebene für anti-Cyclin T1 (CCNT1) Antikörper

CG6292-PA , CG6292-PB , CG6292-PC , CG6292-PD , CycT-PA , CycT-PB , CycT-PC , CycT-PD , CyclinT , cyclin T , cyclin T1 , cyclin T2 , dCyclin T , cyclin-T1-like , CDK9-associated C-type protein , cyclin C-related protein , cyclin-T1 , human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 , cyclin-T , cycT1 , cyclin T1 protein

39961 Drosophila melanogaster
707754 Macaca mulatta
100170179 Xenopus (Silurana) tropicalis
100409876 Callithrix jacchus
100352150 Oryctolagus cuniculus
100583185 Nomascus leucogenys
904 Homo sapiens
12455 Mus musculus
315291 Rattus norvegicus
334465 Danio rerio
734952 Xenopus laevis
486564 Canis lupus familiaris
407194 Bos taurus
100033893 Equus caballus
450146 Pan troglodytes
100860835 Capra hircus
101106415 Ovis aries
Ausgewählte Anbieter für anti-Cyclin T1 (CCNT1) Antikörper
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