Chromobox Homolog 1 Proteine (CBX1)

CBX1 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . Zusätzlich bieten wir Ihnen Chromobox Homolog 1 Antikörper (97) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CBX1 12412 P83917
CBX1 10951 P83916
Ratte CBX1 CBX1 360609  
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Top Chromobox Homolog 1 Proteine auf

Showing 6 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage

CBX1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Chromobox Homolog 1 (CBX1) Interaktionspartnern

Mouse (Murine) Chromobox Homolog 1 (CBX1) Interaktionspartner

  1. We demonstrate an unexpected duality in the role of HP1b: it is essential in ESCs (zeige NR2E3 Proteine) for maintaining pluripotency, while it is required for proper differentiation in differentiated cells.

  2. The N-terminal portion of LBR (zeige LBR Proteine) is probably responsible for the binding to HP1b.

  3. HP1b negatively regulates MMP2 (zeige MMP2 Proteine) expression in a transcriptional level and prevents MMP2 (zeige MMP2 Proteine) activation through reducing the expression of MT1MMP (zeige MMP14 Proteine).

  4. Study concludes that only the 53BP1 (zeige TP53BP1 Proteine) status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Proteine) deficiency, which was not observed for heterochromatin-related proteins HP1beta and BMI1 (zeige BMI1 Proteine).

  5. SUV39h1 (zeige SUV39H1 Proteine) associated with HP1 beta in fibrillarin (zeige FBL Proteine)-positive nucleolar regions.

  6. demonstrate that a green fluorescent protein-HP1beta fusion protein is highly mobile within both the euchromatin and heterochromatin of ex vivo resting T cells; T cell activation greatly increased this mobility

  7. HP1 (zeige CBX5 Proteine) isotypes have specific nonredundant functions; HP1 beta plays an essential role in the shuttling of corepressor transcriptional intermediary factor (TIF)1 (zeige TRIM24 Proteine) beta from eu- to heterochromatin during cell differentiation in vivo.

  8. The localization, dynamics, and mobility of HP1beta in the in mouse preimplantation embryos (pro)nucleus were examined.

  9. HP1alpha (zeige CBX5 Proteine) and HP1beta proteins on the heterochromatin of transcriptionally active oocytes and their absence in transcriptionally silent oocytes suggest that they are necessary for the repression of RNA synthesis in heterochromatin domains.

  10. HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions

Human Chromobox Homolog 1 (CBX1) Interaktionspartner

  1. the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD (zeige TGFBI Proteine)-PXVXL complexes.

  2. Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 (zeige DEFA1 Proteine) protein exemplifying most basal chromatin binding and effects.

  3. increased HP1beta expression is associated with the poor prognosis in breast cancer

  4. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.

  5. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha (zeige CBX5 Proteine) contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.

  6. Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin.

  7. HP1 (zeige DEFA1 Proteine) isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma (zeige CBX3 Proteine) may be a promising therapeutic strategy for treatment of prostate cancer.

  8. The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes.

  9. HP1beta which is associated with PCNA (zeige PCNA Proteine) in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA (zeige PCNA Proteine) may be a component of a DNA repair complex.

  10. The HP1beta interactome is enriched with Lys (zeige LYZ Proteine) methylated proteins.Role of HP1beta in DNA damage response.

Chromobox Homolog 1 (CBX1) Protein Überblick

Protein Überblick

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Genbezeichner und Symbole assoziert mit Chromobox Homolog 1 Proteine (CBX1)

  • chromobox 1 (Cbx1)
  • chromobox 1 (CBX1)
  • chromobox 1 S homeolog (cbx1.S)
  • chromobox homolog 1a (HP1 beta homolog Drosophila) (cbx1a)
  • CBX Protein
  • Cbx-rs2 Protein
  • cbx1 Protein
  • E430007M08Rik Protein
  • HP1-BETA Protein
  • HP1B Protein
  • Hp1beta Protein
  • HP1Hs-beta Protein
  • HP1Hsbeta Protein
  • M31 Protein
  • MOD1 Protein
  • p25beta Protein
  • wu:fe14b09 Protein
  • zgc:55739 Protein

Bezeichner auf Proteinebene für Chromobox Homolog 1 Proteine (CBX1)

HP1 beta , chromobox homolog 1 , chromobox protein homolog 1 , heterochromatin protein 1 homolog beta , heterochromatin protein p25 , modifier 1 protein , HP1 beta homolog , chromobox homolog 1 (HP1 beta homolog Drosophila ) , heterochromatin protein 1-beta , heterochromatin protein p25 beta , chromobox homolog 1 (HP1 beta homolog) , chromobox-like protein 1

12412 Mus musculus
10951 Homo sapiens
491051 Canis lupus familiaris
360609 Rattus norvegicus
444708 Xenopus laevis
374237 Gallus gallus
616506 Bos taurus
326746 Danio rerio
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