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CARD14 encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Zusätzlich bieten wir Ihnen CARD14 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CARD14 Primary Antibody für WB - ABIN528893
Huh, Kim, Kim, Song, Jung, Jeong, Lee, Kim, Lee, An: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. in British journal of cancer 2013
MALT1 (zeige MALT1 Antikörper) deficiency or pharmacological inhibition of MALT1 (zeige MALT1 Antikörper) catalytic activity inhibits pathogenic mutant CARD14-induced cytokine and chemokine (zeige CCL1 Antikörper) expression in human primary keratinocytes.
CARD14/MALT1 (zeige MALT1 Antikörper)-mediated signaling in keratinocytes has a role in psoriasis [review]
The results indicate that the common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF (zeige TNF Antikörper) therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response.
Our findings, combined with the published literature, suggest that Pityriasis Rubra Pilaris Type V, both familial and sporadic, can be caused by CARD14 mutations.
Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10 (zeige BCL10 Antikörper)-MALT1 (zeige MALT1 Antikörper)-dependent NF-kappaB (zeige NFKB1 Antikörper) activation
genetic evidence suggests association of the CARD14 single nucleotide polymorphism rs11652075 and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.
The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 mutational variants seen in cases from Tunisia and other populations.
Genetic interactions of SNPs in CARD14, SENP1 (zeige SENP1 Antikörper) and VEGFA (zeige VEGFA Antikörper) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
analysis of 105 individuals with generalized pustular psoriasis (GPP) identified a low-frequency variant (p.Asp176His) that causes constitutive CARD14 oligomerization
CARD14 protein missense mutation found in patients diagnosed with psoriasis.
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
CARD-containing MAGUK protein 2
, bcl10-interacting maguk protein 2
, card-maguk protein 2
, carma 2
, caspase recruitment domain-containing protein 14
, bcl10-interacting MAGUK protein 2