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CD320 encodes the transcobalamin receptor that is expressed at the cell surface. Zusätzlich bieten wir Ihnen CD320 Proteine (23) und CD320 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320) , and megalin (zeige LRP2 Antikörper) in various tissues during pregnancy.
CD320 role in the hippocampal long-term potentiation and the hippocampal pyramidal neurons.
Severe cobalamin depletion in the central nervous system (CNS) after birth in TCblR knockouts indicates that TCblR is the only receptor responsible for cobalamin uptake in the CNS
In vivo, endogenous PCSK9 (zeige PCSK9 Antikörper) regulates VLDLR (zeige VLDLR Antikörper) protein levels and triglyceride accumulation in adipose tissue.
Diabetic rats showed severe hyperlipidemia on d 21 and 28, with a dramatic decline in VLDL-R (zeige VLDLR Antikörper) protein in skeletal muscle (>90%), heart (approximately 50%) and a loss of adipose tissues itself.
Reelin (zeige RELN Antikörper) binds several receptors, including the VLDL receptor (zeige VLDLR Antikörper) in cultured hippocampus neurons.
VLDL and LDL lowering by gene transfer of the VLDL receptor (zeige VLDLR Antikörper) combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor (zeige LDLR Antikörper)-deficient mice
These data demonstrate a cell-autonomous function of ApoER2 (zeige LRP8 Antikörper), and most likely VLDLR (zeige VLDLR Antikörper) and Dab1 (zeige DAB1 Antikörper), in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin (zeige RELN Antikörper).
The high affinity of apoE4 to the LDLR (zeige LDLR Antikörper) enhances VLDL sequestration on the hepatocyte surface but delays their internalization.
Data show that thrombospondin-1 (THBS-1 (zeige THBS1 Antikörper)) is a novel physiological ligand for ApoER2 (zeige LRP8 Antikörper) and VLDLR (zeige VLDLR Antikörper), and that lack of THBS-1 (zeige THBS1 Antikörper) results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB.
Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2 (zeige TCN2 Antikörper)) and the transcobalamin II (zeige TCN2 Antikörper)-receptor (TCblR), were found to influence several clinical traits of cobalamin deficiency.
The soluble transcobalamin receptor is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta.
Transcobalamin II (TCN2 (zeige TCN2 Antikörper) 67A>G and TCN2 (zeige TCN2 Antikörper) 776C>G) and transcobalamin II (zeige TCN2 Antikörper) receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion
Data indicate that only the extracellular region (aa 32-229) of TCblR/CD320 is needed for transcobalamin-cobalamin (TC-Cbl (zeige CBL Antikörper)) binding.
Proliferating cancer cells express measurable levels of TCII (zeige TCN2 Antikörper) and TCII (zeige TCN2 Antikörper)-R.
TCblr SNP were associated with omphalocele suggests that disruption of methylation reactions, in which folate, vitamin B12 (zeige NDUFB3 Antikörper), and homocysteine play critical parts, may be a risk factor for omphalocele.
Our data suggest that variation in TCblR plays a role in neural tube defect risk and that these variants may modulate cobalamin metabolism.
the cell cycle associated expression of TCblR appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle.
Analysis of TCblR/CD320, the gene for the receptor for cellular uptake of transcobalamin-bound cobalamin, identified a homozygous single codon deletion, c.262_264GAG (p.E88del), resulting in the loss of a glutamic acid residue.
Confocal microscopy of tonsil sections revealed co-localization of CD320 with CD19 (zeige CD19 Antikörper) and CD38 but not with CD3 (zeige CD3 Antikörper) indicating that germinal center B cells expressed CD320 in addition to follicular dendritic cells.
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, putative VLDL lipoprotein receptor
, transcobalamin receptor
, 8D6 antigen
, CD320 antigen
, FDC-signaling molecule 8D6