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BVES encodes a member of the POP family of proteins containing three putative transmembrane domains. Zusätzlich bieten wir Ihnen Blood Vessel Epicardial Substance Antikörper (47) und viele weitere Produktgruppen zu diesem Protein an.
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a loss of zBves affects the proteins involved in the pathway of the PAR (zeige AFG3L2 Proteine) junctional complex, especially aPKC, and both aPKC and Bves are indispensable to claudin expression.
Study shows that EGFR (zeige EGFR Proteine) negatively regulates POPDC1 expression in breast cancer cell lines and that overexpression of POPDC1 can reduce EGFR (zeige EGFR Proteine)-mediated cell migration and proliferation in breast cancer cells.
BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Results also suggest that BVES promotes the post-translational degradation of c-Myc.
Forced expression of POPDC1(S201F) in a murine cardiac muscle cell line (HL-1 (zeige ASGR1 Proteine)) increased hyperpolarization and upstroke velocity of the action potential
These results suggest that down-regulation of BVES in hepatocellular carcinoma induces epithelial-mesenchymal transition, thus promoting invasion and metastasis in HCC (zeige FAM126A Proteine) cells.
Coding sequence and splice junctions of BVES were sequenced in 114 unrelated patients with Tetralogy of Fallot and 400 unrelated healthy individuals.Four novel BVES mutations were identified in patients with TOF (zeige FEZF2 Proteine) but not in the 400 controls.
Popdc1 (Bves) mod (zeige POPDC2 Proteine)ulates cardiac pacemaker activity in response (zeige KCNAB2 Proteine) to str (zeige KCNK2 Proteine)ess and displays high expression levels in the sinus node. The Popeye domain acts as a high-affinity cAMP binding domain and Popdc proteins interact with the ion channel TREK-1.
Low Bves expression is associated with gastric cancer progression.
BVES was found to be underexpressed in all stages of colorectal carcinoma and in adenomatous polyps, indicating its suppression occurs early in transformation.
Bves expression and localization can regulate RhoA (zeige RHOA Proteine) and ZONAB/DbpA (zeige CSDA Proteine) activity.
Data suggest that POPDC gene expression is modified in end-stage heart failure in humans in a manner suggesting regulatory and/or functional differences between the three family members and that POPDC1 is particularly susceptible to this condition.
BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Additionally, these results provide the first in vivo and genetic evidence supporting the hypothesis that BVES regulates Wnt (zeige WNT2 Proteine) activity.
Bves and NDRG4 (zeige NDRG4 Proteine) regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection.
Popdc1 and Popdc2 (zeige POPDC2 Proteine) proteins interact with the potassium channel (zeige KCNAB2 Proteine) TREK-1 (zeige KCNK2 Proteine), which leads to increased cell surface expression and enhanced current density
cell surface Bves/Pop1A is composed of an extracellular amino terminus, three transmembrane domains, and a cytoplasmic carboxyl terminus, which regulates cellular distribution of Bves/Pop1A during coronary vessel development
Bves directly interacts with GEFT and is a novel regulator of the Rac1 and Cdc42 (zeige CDC42 Proteine) signaling cascades.
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene.
popeye domain containing 1
, popeye domain-containing protein 1
, blood vessel epicardial substance
, Popeye domain-containing protein 1
, Popeye protein 1
, blood vessel epicardial substance-like
, popeye protein 1
, popeye 1
, popeye domain-containing 1
, POP1C protein
, popeye domain containing protein 1