AF4/FMR2 Family, Member 4 Proteine (AFF4)

The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia. Zusätzlich bieten wir Ihnen AFF4 Antikörper (70) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
AFF4 27125 Q9UHB7
AFF4 93736 Q9ESC8
Ratte AFF4 AFF4 303132  
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

AFF4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu AF4/FMR2 Family, Member 4 (AFF4) Interaktionspartnern

Human AF4/FMR2 Family, Member 4 (AFF4) Interaktionspartner

  1. The TAR (zeige RBM8A Proteine) central loop contacts the CycT1 (zeige CCNT1 Proteine) Tat (zeige TAT Proteine)-TAR (zeige RBM8A Proteine) recognition motif (TRM) and the second Tat (zeige TAT Proteine) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR (zeige RBM8A Proteine) complex despite not touching the RNA, explaining how it enhances TAR (zeige RBM8A Proteine) binding to the SEC 50-fold.

  2. AFF4 is positioned to make unexpected direct contacts with HIV Tat (zeige TAT Proteine), and Tat (zeige TAT Proteine) enhances P-TEFb (zeige CCNT1 Proteine)/CCNT1 (zeige CCNT1 Proteine) affinity for AFF4.

  3. missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (zeige NIPBL Proteine)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)

  4. HIV-1 Tat (zeige TAT Proteine) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.

  5. overexpression of AFF2 (zeige AFF2 Proteine)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.

  6. Through the bridging functions of Tat (zeige TAT Proteine) and AFF4, P-TEFb (zeige CCNT1 Proteine) and ELL2 (zeige ELL2 Proteine) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.

  7. AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.

  8. MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (zeige TAT Proteine)-transactivation.

  9. Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]

Mouse (Murine) AF4/FMR2 Family, Member 4 (AFF4) Interaktionspartner

  1. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (zeige MLLT1 Proteine)/3 and AFF proteins that is critically important for MLL (zeige MLL Proteine)-mediated transformation of HPCs

  2. AFF4 may therefore help to maintain activation of AMPK (zeige PRKAA1 Proteine) downstream signaling under conditions of prolonged stimulation with ghrelin (zeige GHRL Proteine), such as during fasting.

  3. AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.

  4. Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II

  5. In the absence of Runx1 (zeige RUNX1 Proteine) on the silencer, P-TEFb (zeige CCNT1 Proteine) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (zeige CD4 Proteine) gene

AFF4 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).

Genbezeichner und Symbole assoziert mit AFF4

  • AF4/FMR2 family member 4 L homeolog (aff4.L)
  • AF4/FMR2 family member 4 (AFF4)
  • AF4/FMR2 family, member 4 (aff4)
  • AF4/FMR2 family, member 4 (Aff4)
  • AF5Q31 Protein
  • AFF4 Protein
  • Alf4 Protein
  • Laf4l Protein
  • MCEF Protein
  • RA_m002_jsmFBA6Br Protein

Bezeichner auf Proteinebene für AFF4

AF4/FMR2 family, member 4 , ALL1 fused gene from 5q31 , AF4/FMR2 family member 4-like , AF4/FMR2 family member 4 , ALL1-fused gene from chromosome 5q31 protein , major CDK9 elongation factor-associated protein

446225 Xenopus laevis
462058 Pan troglodytes
100137227 Papio anubis
100328920 Oryctolagus cuniculus
100403628 Callithrix jacchus
556421 Danio rerio
100548612 Meleagris gallopavo
27125 Homo sapiens
93736 Mus musculus
416337 Gallus gallus
474678 Canis lupus familiaris
541306 Bos taurus
303132 Rattus norvegicus
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