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The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia. Zusätzlich bieten wir Ihnen AFF4 Antikörper (70) und viele weitere Produktgruppen zu diesem Protein an.
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The TAR (zeige RBM8A Proteine) central loop contacts the CycT1 (zeige CCNT1 Proteine) Tat (zeige TAT Proteine)-TAR (zeige RBM8A Proteine) recognition motif (TRM) and the second Tat (zeige TAT Proteine) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR (zeige RBM8A Proteine) complex despite not touching the RNA, explaining how it enhances TAR (zeige RBM8A Proteine) binding to the SEC 50-fold.
AFF4 is positioned to make unexpected direct contacts with HIV Tat (zeige TAT Proteine), and Tat (zeige TAT Proteine) enhances P-TEFb (zeige CCNT1 Proteine)/CCNT1 (zeige CCNT1 Proteine) affinity for AFF4.
missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (zeige NIPBL Proteine)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)
HIV-1 Tat (zeige TAT Proteine) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
overexpression of AFF2 (zeige AFF2 Proteine)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.
Through the bridging functions of Tat (zeige TAT Proteine) and AFF4, P-TEFb (zeige CCNT1 Proteine) and ELL2 (zeige ELL2 Proteine) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.
AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.
MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (zeige TAT Proteine)-transactivation.
Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]
define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (zeige MLLT1 Proteine)/3 and AFF proteins that is critically important for MLL (zeige MLL Proteine)-mediated transformation of HPCs
AFF4 may therefore help to maintain activation of AMPK (zeige PRKAA1 Proteine) downstream signaling under conditions of prolonged stimulation with ghrelin (zeige GHRL Proteine), such as during fasting.
AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.
Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II
In the absence of Runx1 (zeige RUNX1 Proteine) on the silencer, P-TEFb (zeige CCNT1 Proteine) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (zeige CD4 Proteine) gene
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).
AF4/FMR2 family, member 4
, ALL1 fused gene from 5q31
, AF4/FMR2 family member 4-like
, AF4/FMR2 family member 4
, ALL1-fused gene from chromosome 5q31 protein
, major CDK9 elongation factor-associated protein