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Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (zeige TOP2 Proteine)-targeting agents.
We demonstrated that Nup98 (zeige NUP98 Proteine)-TopIIbeta and Nup98 (zeige NUP98 Proteine)-SETBP1 (zeige SETBP1 Proteine) negatively regulate the XPO1 (zeige XPO1 Proteine)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (zeige NUP98 Proteine)-fusion proteins induce tumorigenesis.
TOP2 (zeige TOP2 Proteine) and BAF (zeige BANF1 Proteine) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (zeige BANF1 Proteine) complexes.
Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.
Inhibition of DNA topoisomerase II (zeige TOP2 Proteine) selectively reduces the threat of tumorigenicity
Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.
Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.
TOP2beta (zeige TOP2B Proteine) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.
Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.
studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (zeige BANF1 Proteine) complexes and suggest that this activity contributes to the role of BAF (zeige BANF1 Proteine) subunits as tumour suppressors
Data show that comparing with Ki-67 (zeige MKI67 Proteine) and TOP2A, RacGAP1 (zeige RACGAP1 Proteine) allowed for a clearer prognostic statement.
These findings reveal a novel, p53 (zeige TP53 Proteine)-independent activity of Mdm2 (zeige MDM2 Proteine) and have important implications for the choice of chemotherapeutic agents in the treatment of Mdm2 (zeige MDM2 Proteine)-overexpressing tumors. Herein is shown that tumor cells with MDM2 (zeige MDM2 Proteine) amplification are selectively resistant to treatment with topoisomerase II (zeige TOP2 Proteine) poisons but not other DNA damaging agents
The methodology is useful for a high-throughput analysis of drugs that poison Top2, allowing not just the discrimination of the Top2 isoform that is targeted but also to track its removal
TOP2A was identified in association with the progression and prognosis of pancreatic ductal adenocarcinoma probably by regulating cell cycle and p53 (zeige TP53 Proteine) signaling pathway.
the relation between TOP2A levels and sensitivity for doxorubicin was examined, confirming reports that TOP2A mRNA levels were overexpressed in MPNST and showing that MPNST cell lines exhibited relatively high TOP2A protein levels and sensitivity to doxorubicin.
The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIalpha, while preserving the nuclear localization signal (NLS (zeige ALDH1A2 Proteine)), enhances the decatenation checkpoint and sensitivity to topo II (zeige TOP2 Proteine)-targeted drugs. Mutation of Y640 in topo IIalpha inhibi...
Tumors with higher topoisomerase IIalpha and/or mitosin (zeige CENPF Proteine) expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up
Both the genome instability and cell death of MRE11 (zeige MRE11A Proteine)-null and MRE11 (zeige MRE11A Proteine)-mutated H129N cells are significantly reversed by overexpression of Tdp2 (zeige TDP2 Proteine), an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 (zeige MRE11A Proteine) nuclease (zeige DCLRE1C Proteine) activity is likely to remove the DNA lesions.
we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (zeige TCF4 Proteine) and interacts with Wnt (zeige WNT2 Proteine) response elements (WREs) and promoters of direct target genes of TCF (zeige HNF4A Proteine) transcription, including: MYC (zeige MYC Proteine), vimentin (zeige VIM Proteine), AXIN2 (zeige AXIN2 Proteine) and LEF1 (zeige LEF1 Proteine)
This study shows that both survivin (zeige BIRC5 Proteine) and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (zeige IDH1 Proteine)-mutation status
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
DNA topoisomerase II, alpha isozyme
, DNA Topoisomerase II alpha
, DNA topoisomerase 2-alpha
, topoisomerase (DNA) 2 alpha
, DNA gyrase
, DNA topoisomerase (ATP-hydrolyzing)
, DNA topoisomerase II, 170 kD
, DNA topoisomeraseII_alpha
, DNA topoisomerase 2-beta
, DNA topoisomerase II, beta isozyme