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Data suggest that Clock1a (zeige CLOCK Proteine) coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a (zeige CLOCK Proteine) alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a (zeige CLOCK Proteine) activates Smad3a promoter via its E-box1 element. (Clock1a (zeige CLOCK Proteine) = clock circadian regulator (zeige CLOCK Proteine) a; Nodal = nodal modulator 1 (zeige NOMO1 Proteine); Smad3a = SMAD (zeige SMAD1 Proteine) family member 3a)
Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (zeige TGFB1 Proteine) control of zebrafish spinal cord development
Nodal signaling and mesendoderm induction depend on Smad2 (zeige SMAD2 Proteine)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (zeige SMAD2 Proteine)/3 signaling and embryonic patterning.
although the role of Smad (zeige SMAD1 Proteine) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (zeige TDP2 Proteine) provides insight into a novel Smad (zeige SMAD1 Proteine) partner that plays an essential role in the fine-tuning of this signal transduction cascade
Smad2 (zeige SMAD2 Proteine)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (zeige TGFB1 Proteine)/Smad3 signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
The results suggest that co-expression of active SMAD2 (zeige SMAD2 Proteine)/3 could enhance multiple types of transcription factors (TF)-based cell identity conversion and therefore be a powerful tool for cellular engineering.
The SMAD3 SNP rs12901499 GA genotype and G variant may increase the risk of hip osteoarthritis in Chinese Han patients.
We found that ITZ treatment was efficient in suppressing EMT (zeige ITK Proteine) and that the effect of ITZ was partially mediated by impaired TGF-b/SMAD2 (zeige SMAD2 Proteine)/3 signaling. The role of TGF-b/SMAD2 (zeige SMAD2 Proteine)/3 signaling in mediating the effect of ITZ was confirmed based on the results that recombinant TGF-b induced, but the TGF-b neutralizing antibody inhibited EMT (zeige ITK Proteine) as well as the invasion and migration of pancreatic cancer cells
Positive cooperativity of Smad3 and STAT3 (zeige STAT3 Proteine) during epithelial-mesenchymal transition [Review].
CXCL12 (zeige CXCL12 Proteine) activates the MEKK1 (zeige MAP3K1 Proteine)/JNK (zeige MAPK8 Proteine) signaling pathway, which in turn initiates SMAD3 phosphorylation, its translocation to nuclei, and recruitment of SMAD3 to the CTGF (zeige CTGF Proteine) promoter, which ultimately induces CTGF (zeige CTGF Proteine) expression in human lung fibroblasts.
SMAD2 (zeige SMAD2 Proteine)/3 interactome reveals that TGFbeta (zeige TGFB1 Proteine) controls m(6)A mRNA methylation in pluripotency
these results indicated that Bone marrow-derived mesenchymal stem cells -conditioned medium suppressed the epithelial-mesenchymal transition which might be associated with TGF-B1/Smad3. This study provides the theoretical basis for the research of the mechanisms responsible for pulmonary disease.
our findings demonstrated that thymoquinone suppressed the metastatic phenotype and reversed EMT (zeige ITK Proteine) of prostate cancer cells by negatively regulating the TGF-beta (zeige TGFB1 Proteine)/Smad2 (zeige SMAD2 Proteine)/3 signaling pathway. These findings suggest that thymoquinone is a potential therapeutic agent against prostate cancer which functions by targeting TGF-beta (zeige TGFB1 Proteine)
The present findings indicate that RACK1 (zeige GNB2L1 Proteine) silencing attenuates renal fibrosis by suppressing the activation of TGF-beta1 (zeige TGFB1 Proteine)/Smad3 signaling pathway in HK-2 (zeige HK2 Proteine) cells. Thus, RACK1 (zeige GNB2L1 Proteine) may serve as a novel regulator of renal fibrosis.
was found that treatment with iPSC-CM markedly reduced the proliferation of TGF-beta1 (zeige TGFB1 Proteine)-exposed cells, and the activities of TGF-beta1 (zeige TGFB1 Proteine), Smad-2 (zeige SMAD2 Proteine) and Smad-3. Accompanied by alterations in the expression of the indicated molecules, the lung structure of mice with PF was also markedly ameliorated.
E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2 (zeige SMAD2 Proteine)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
HSP70 (zeige HSP70 Proteine) indirectly interacted with Smad3.
Activin A (zeige INHBA Proteine) and overexpression of SMAD2 (zeige SMAD2 Proteine)/3 significantly promoted expressions of porcine NANOG (zeige NANOG Proteine) and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Proteine)/OCT4 (zeige POU5F1 Proteine) expression.
Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition
SP1 (zeige SP1 Proteine) and SMAD3 are required for high glucose-induced p21(WAF1 (zeige CDKN1A Proteine)) gene transcription in LLC-PK1 (zeige PKLR Proteine) cells.
Cav-3 (zeige CAV3 Proteine) and Smad3 may be involved in the occurrence and development of viral myocarditis.
In pancreata of mice and rats, TGFB (zeige TGFB1 Proteine) promotes peripheral nociceptive sensitization via a direct effect on primary sensory neurons mediated by intra-neuronal SMAD3.
We provide the evidence that over-expression of miR (zeige MLXIP Proteine)-145 could inhibit osteoclast differentiation, at least partially, by decreasing Smad3 expression
Activin signaling through SMAD2 (zeige SMAD2 Proteine)/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 (zeige TLR7 Proteine) expression and beta-catenin (zeige CTNNB1 Proteine) activation
SMAD3 is regulated by miR (zeige MLXIP Proteine)-489 in pulmonary fibrosis.miR-489 suppresses fibroblast differentiation by targeting Smad3.
Alendronate (ALN)-augmented IL-1beta production and cell death require Smad3 and ASC activation, and SIS3 and anti-ASC antibodies may serve as palliative agents for necrotizing inflammatory diseases caused by ALN
CRP (zeige CRP Proteine) is pathogenic in type-2 diabetes (T2DN). CRP (zeige CRP Proteine) may promote CD32b- NF-kappaB (zeige NFKB1 Proteine) signaling to mediate renal inflammation; whereas, CRP (zeige CRP Proteine) may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR (zeige FRAP1 Proteine) signaling.
A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-beta (zeige TGFB1 Proteine) in mouse endometrium.
These findings indicate that both systemic factors and intrinsic properties of skin cells contribute to enhanced wound healing and less inflammatory reaction observed in Smad3 knock-out mice.
Data show that the transcription factor Smad3 (Smad3) gene was expressed ubiquitously in 11 bovine tissues and displayed different expression patterns between muscle and adipose tissue.
the present work provides evidence supporting a functional role of SMAD2 (zeige SMAD2 Proteine)/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (zeige SMAD2 Proteine)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
MAD homolog 3
, MAD homolog 3a
, MAD, mothers against decapentaplegic homolog 3
, SMA- and MAD-related protein 3
, SMAD, mothers against DPP homolog 3
, mad homolog JV15-2
, mad protein homolog
, mothers against DPP homolog 3
, mothers against decapentaplegic homolog 3
, SMAD 3
, TGF beta response effector Smad3
, TGF-beta response effector Smad3
, Smad 3
, MAD (mothers against decapentaplegic, Drosophila) homolog 3
, SMAD family member 3