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Skeletal muscle stem cells underwent a switch from beta-catenin-Lef1 to Smad3-Lef1 interactions during the postnatal switch from proliferation to quiescence, with beta-catenin-Lef1 interactions recurring during damage-induced reactivation.
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serine 204 within Smad3 is the key Pin1-binding site during inhibition of myoblast fusion
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our data suggest that RepSox regulates osteoclast differentiation, bone resorption, and OVX-induced OP via the suppression of the Smad3 and JNK/AP-1 pathways.
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Depletion of Dicer and microRNAs may upregulate Smad2/3-related signaling pathway to enhance the progression of chronic kidney disease.
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Genome-wide experiments demonstrate that the proneural factor ASCL1 assists SMAD3 in the binding to a subset of enhancers. Once located at the enhancers, SMAD3 recruits the histone demethylase JMJD3 and the remodeling factor CHD8, creating the appropriate chromatin landscape to allow enhancer transcription and posterior gene activation
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miR-21 knockout exacerbated AngII-induced thoracic aortic dissecting aneurysm formation in mice, which was associated with TGF-beta/Smad3 signaling dysfunction.
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Our findings generate a mouse model to study the roles of SMAD2/3 in the uterus and serve to provide insight into the mechanism by which the endometrium can escape the plethora of growth regulatory proteins
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Here the authors have demonstrated that TGF-beta/Smad signaling plays an important role in Laser-induced choroidal neovascularization formation through down-regulation of VEGF and TNF-alpha expressions.
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In healing myocardial infarction, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional outcomes that may involve activation of an integrin/reactive oxygen axis.
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The application of the combined siRNAs of SPARC, CCR2, and SMAD3 genes ameliorated inflammation and fibrosis in bleomycin-induced mice. It systemically reinstated multiple biopathways, probably through controlling on different cell types including fibroblasts, monocytes/macrophages, endothelial cells and others.
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Ash1l upregulates Smad3 expression by directly targeting Smad3 promoter to increase local H3K4 trimethylation.
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Data indicate E4BP4/NFIL3 as a direct Smad3 target gene critical for NK cell differentiation.
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Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
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These data indicate that SMAD3- and beta-catenin-dependent induction occurs in the taurine transporter knockout mouse
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Cav-3 and Smad3 may be involved in the occurrence and development of viral myocarditis.
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In pancreata of mice and rats, TGFB promotes peripheral nociceptive sensitization via a direct effect on primary sensory neurons mediated by intra-neuronal SMAD3.
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We provide the evidence that over-expression of miR-145 could inhibit osteoclast differentiation, at least partially, by decreasing Smad3 expression
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Activin signaling through SMAD2/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
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conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation
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SMAD3 is regulated by miR-489 in pulmonary fibrosis.miR-489 suppresses fibroblast differentiation by targeting Smad3.