Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219
Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016
The non-Smad (zeige SMAD1 Proteine) JNK (zeige MAPK8 Proteine) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (zeige SMAD1 Proteine) pathway, and this nuclear movement is associated with Smad (zeige SMAD1 Proteine) signal transduction toward the nucleus.
The results of this study found that Bptf and TGF-beta (zeige TGFB1 Proteine)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Proteine) expression and hence neural posteriorization.
Smad2 and Eomesodermin (zeige EOMES Proteine) a (Eomesa (zeige EOMES Proteine)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Proteine) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
Nodal signaling through the Smad2/3 pathway up-regulated Slug, Snail (zeige SNAI1 Proteine) and c-Myc (zeige MYC Proteine) to induce EMT (zeige ITK Proteine), thereby promotingVasculogenic mimicry (VM) formation.
this study shows that EGF (zeige EGF Proteine) induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail (zeige SNAI1 Proteine) signaling pathway in breast cancer cells
Multiple myeloma cells adapted to long-term exposure to hypoxia exhibit stem cell characteristics with TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) pathway activation.
a novel heterozygous missense mutation (c.833C>T, p.A278V) in the SMAD2 gene in a family with early onset aortic aneurysms
Data suggest that oncogenic Y-box binding protein 1 (YB-1 (zeige YBX1 Proteine)) indirectly enhances transforming growth factor beta (TGFbeta (zeige TGFB1 Proteine)) signaling cascades via Sma (zeige SMN1 Proteine)/Mad related protein 2 (Smad2)phospho-activation and may represent a promising factor for future diagnosis and therapy of breast cancer.
Asiaticoside hindered the invasive growth of KFs (zeige GDF6 Proteine) by inhibiting the GDF-9 (zeige GDF9 Proteine)/MAPK (zeige MAPK1 Proteine)/Smad (zeige SMAD1 Proteine) pathway.
High Smad2 expression is associated with invasion and metastasis in pancreatic ductal adenocarcinoma.
Data indicate that miR (zeige MLXIP Proteine)-206 inhibits neuropilin-1 (NRP1 (zeige NRP1 Proteine)) and SMAD2 gene expression by directly binding to their 3'-UTRs.
Results show that members of the Activin branch of the TGFbeta (zeige TGFB1 Proteine) signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
Grg4 occupancy at the Xnr1 (zeige NODAL Proteine) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (zeige FOXH1 Proteine) at the Xnr1 (zeige NODAL Proteine) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (zeige GDF11 Proteine) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (zeige INHBA Proteine) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG Proteine) and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Proteine)/OCT4 (zeige POU5F1 Proteine) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
Results suggest that Smad2/3 linker threonine phosphorylation is expressed during acinar-ductal metaplasia.
NODAL/Activin signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms.
Blocking Smad2/3 signaling in pluripotent stem cells results in epigenetic changes that enhance the capacity for endoderm differentiation.
cells expressing mutant huntingtin (zeige HTT Proteine) have a dysregulated transcriptional response to epidermal growth factor (zeige EGF Proteine) stimulation
Smad2- and Smad3 (zeige SMAD3 Proteine)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (zeige TGFB1 Proteine)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (zeige LRRC32 Proteine) is involved in up-regulation of Tgfb3 (zeige TGFB3 Proteine) and is essential for embryogenesis of palate; Garp (zeige LRRC32 Proteine) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (zeige LRRC32 Proteine) = glycoprotein A repetitions predominant (zeige LRRC32 Proteine) protein; Tgfb3 (zeige TGFB3 Proteine) = transforming growth factor beta 3 (zeige TGFB3 Proteine))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (zeige TPM1 Proteine), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (zeige TGFB1 Proteine), Smad2, Smad3 (zeige SMAD3 Proteine), Notch2 (zeige NOTCH2 Proteine) and Notch3 (zeige NOTCH3 Proteine) which, in turn, results in TGFbeta (zeige TGFB1 Proteine) and Notch (zeige NOTCH1 Proteine) pathway activation.
P311 (zeige C5orf13 Proteine) is a novel TGFbeta1 (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (zeige SMAD7 Proteine) expression was increased after treatment with osthole.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2