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anti-Human PLK1 Antikörper:
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Human Polyclonal PLK1 Primary Antibody für IHC - ABIN966866
Lake, Jelinek: Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase. in Molecular and cellular biology 1994
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Human Polyclonal PLK1 Primary Antibody für IHC - ABIN966867
Golsteyn, Schultz, Bartek, Ziemiecki, Ried, Nigg: Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. in Journal of cell science 1994
Show all 7 Pubmed References
Human Monoclonal PLK1 Primary Antibody für FACS, IHC - ABIN1098105
Lin, Sun, Wang: Suppression of Polo like kinase 1 (PLK1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death. in Cellular signalling 2011
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Human Monoclonal PLK1 Primary Antibody für WB - ABIN967616
Ando, Ozaki, Yamamoto, Furuya, Hosoda, Hayashi, Fukuzawa, Nakagawara: Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. in The Journal of biological chemistry 2004
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Xenopus laevis Polyclonal PLK1 Primary Antibody für WB - ABIN152619
Kumagai, Dunphy: Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. in Science (New York, N.Y.) 1996
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Human Monoclonal PLK1 Primary Antibody für ICC, ELISA - ABIN969580
Lee, Rhee: PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. in The Journal of cell biology 2011
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Human Polyclonal PLK1 Primary Antibody für IHC (p), WB - ABIN392446
Negishi, Kumano, Nishida: Polo-like kinase 1 is required for localization of Posterior End Mark protein to the centrosome-attracting body and unequal cleavages in ascidian embryos. in Development, growth & differentiation 2011
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Human Polyclonal PLK1 Primary Antibody für ICC, IF - ABIN256400
Seeger-Nukpezah, Liebau, Höpker, Lamkemeyer, Benzing, Golemis, Schermer: The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1. in PLoS ONE 2012
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Human Polyclonal PLK1 Primary Antibody für IHC, ELISA - ABIN129581
Adler, Müller, Rached, Dekant, Mally: Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. in Carcinogenesis 2009
Human Monoclonal PLK1 Primary Antibody für ICS - ABIN1177153
Peter, Gleixner, Cerny-Reiterer, Herrmann, Winter, Hadzijusufovic, Ferenc, Schuch, Mirkina, Horny, Pickl, Müllauer, Willmann, Valent: Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536. in Haematologica 2011
Study shows that cnn exon1A-encoded proteins interact with Polo at 2 residues and that this interaction is required for polar body and pericentriolar matrix formation in syncytial embryos.
Cdk1 (zeige CDK1 Antikörper) phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.
Polo is an important in vivo regulator of the pathological functions of APP (zeige APP Antikörper).
Both conditions impaired NSC lineage progression. Ca(2 (zeige CA2 Antikörper)) mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro
During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome.
Polo kinase is required for localization and activity of the chromosomal passenger complex in mitosis and meiosis.
Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement.
Results show that Polo kinase positively and negatively regulates Augmin distribution for microtubule nucleation and acentrosomal spindle formation.
Regulation of Polo by Aurora B (zeige AURKB Antikörper) and Map205 is required for cytokinesis.
These data indicate APC (zeige APC Antikörper)(Cort (zeige CORT Antikörper)) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.
Novel roles for Plk and GSK3 regulation of ADAM13 (zeige ADAM33 Antikörper) function in cranial neural crest cell migration.
Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development.
Coordinated interplays between Plx1 and Gwl (zeige MASTL Antikörper) are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.
the penultimate CRS (zeige CARS Antikörper) serine (Ser (zeige SIGLEC1 Antikörper) 101) of cyclin b1 (zeige CCNB1 Antikörper) is a Plx substrate
Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes.
Plx1 cooperates with CaMKII (zeige CAMK2G Antikörper) to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed.
Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3 (zeige TRIM32 Antikörper)/2 epitope and targeting structural and checkpoint proteins to kinetochores.
Polo-like kinase Plx1 is an essential factor for calcium ion-induced meiotic exit during cytostatic factor arrest
Polo-like kinase (Plx1) phosphorylates xTRF1 in vitro and the mitotic xTRF1-chromatin association was significantly impaired when Plx1 was immunodepleted from the extracts (Plx1).
Cdk1 (zeige CDK1 Antikörper) phosphorylation of BubR1 (zeige BUB1B Antikörper) controls spindle checkpoint arrest and plk-mediated formation of the 3F3 (zeige TRIM32 Antikörper)/2 epitope.
Polo-like kinase inhibition can sensitize cholangiocarcinoma cells to cisplatin-induced apoptosis with proteasomal Bcl-2 (zeige BCL2 Antikörper) degradation as an additional pro-apoptotic effect.
Results showed that Polo-like kinase 1 (Plk1) plays an important role in the conversion of cancer stem cells (CSCs) between active and quiescent states.
Authors demonstrated that WDR62 (zeige WDR62 Antikörper) is a PLK1 substrate that is phosphorylated at Ser (zeige SIGLEC1 Antikörper) 897, and that this phosphorylation at the spindle poles promotes astral microtubule assembly to stabilize spindle orientation.
findings thus elucidate a critical role for Plk1 in CyclinB1-Cdk1 (zeige CDK1 Antikörper) activation and mitotic entry and outline how CyclinA2-Cdk (zeige CDK4 Antikörper), an S-promoting factor, poises cells for commitment to mitosis.
Data show that a microRNA-mimic to increase miR (zeige MLXIP Antikörper)-34a together with siRNA to silence PLK1 oncogene (zeige RAB1A Antikörper) prolonged survival.
PLK1 inhibitors may be effective for patients with high-risk or relapsed neuroblastomas with upregulated PLK1.
The authors found that SYP (zeige SYP Antikörper)-4 is phosphorylated dependent on Polo-like kinases PLK-1/2. They propose a model in which Polo-like kinases recognize crossover designation and phosphorylate SYP (zeige SYP Antikörper)-4 thereby stabilizing the synaptonemal complex and making chromosomes less permissive for further double-strand break formation.
Data suggest that FBXW7 (zeige FBXW7 Antikörper), MCL1 (zeige MCL1 Antikörper) and PLK1 may be relevant predictive markers of tumor progression and response to paclitaxel treatment.
we have identified lnc-RI as a new regulator of mitosis which acts by releasing PLK1 mRNA activity via competition for binding to miRNA-210-3p.
A FAK (zeige PTK2 Antikörper)-Src (zeige SRC Antikörper) signaling pathway downstream of integrin-mediated cell adhesion was found to decelerate both PLK1 degradation and CEP55 (zeige CEP55 Antikörper) accumulation at the midbody. These data identify the regulation of PLK1 and CEP55 (zeige CEP55 Antikörper) as steps where integrins exert control over the cytokinetic abscission.
Plk1 plays an essential role during the meiosis I/meiosis II transition in porcine oocytes, and the regulation is associated with Plk1's effects on homologous chromosome segregation in the Anaphase-telophase I stage.
Thus, these results indicated that Plk1 is essential for porcine embryos to complete the first mitotic division. Furthermore, Plk1 regulation was associated with effects on spindle assembly and chromosome arrangement
PLK1 might play a critical role in vascular smooth muscle cell mitosis in hyperplastic intima of the injured vessels.
Data show that Polo-like kinase 1 is activated before M phase promoting factor (MPF (zeige MSLN Antikörper)), which is consistent with its role in activating MPF (zeige MSLN Antikörper) in mammalian oocytes.
integrity is required for PLK1 localization with SUMO-1 (zeige SUMO1 Antikörper) but not with SUMO-2 (zeige SUMO2 Antikörper)/3. Inhibition of SUMOylation disrupts proper meiotic bipolar spindle organization and spindle-kinetochore attachment.
CIP2A (zeige KIAA1524 Antikörper) acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A (zeige AURKA Antikörper) during meiotic maturation in mouse oocytes
Plk1 overexpression may contribute to tumor formation by both inducing chromosomal instability and suppressing the DDR (zeige DDR1 Antikörper) pathway.
Plk1 is essential for the mammalian embryonic development, and its depletion leads to mitotic alterations and lethality at different stages during mammalian development.
Plk1 regulated angiotensin II-dependent activation of RhoA (zeige RHOA Antikörper) and actomyosin dynamics in VSMCs in a mitosis-independent manner. This regulation depended on Plk1 kinase activity. Plk1 haploinsufficiency in mice did not induce obvious cell proliferation defects but did result in arterial structural alterations, which frequently led to aortic rupture and death.
The findings reveal a PLK1-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.
These data implicate the insulin (zeige INS Antikörper)-FoxM1 (zeige FOXM1 Antikörper)/PLK1/CENP-A (zeige CENPA Antikörper) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
centrosome maturation occurs during interphase in an MLK (zeige MUSK Antikörper)-dependent manner, independent of the classic mitotic kinase, Plk1.
centrosome protein Dzip1 (zeige DZIP1 Antikörper) mediates the assembly of the BBSome-Dzip1 (zeige DZIP1 Antikörper)-PCM1 (zeige MBD1 Antikörper) complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 (zeige DZIP1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 (zeige DZIP1 Antikörper) and the BBSome from the CS.
These findings suggest that Plk1 regulates smooth muscle contraction by modulating vimentin (zeige VIM Antikörper) phosphorylation at Ser (zeige SIGLEC1 Antikörper)-56.
Report the 2.3-A crystal structure of the complex of the N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD together with a PBD-binding motif of Drosophila melanogaster microtubule-associated protein (zeige FAM82A2 Antikörper) 205 (Map205(PBM)).
Studies demonstrate that Plk1 is required for embryonic proliferation because its activity is crucial for mitotic integrity.
for the first time that Plk1 can accommodate extended ATP-competitive compounds that project toward the adaptive pocket and help the enzyme order its activation segment
PLK1 inhibition mitigates autophagy in cancer cells both under nutrient starvation and sufficiency, and a role of PLK1 in autophagy is also observed in the invertebrate model organism Caenorhabditis elegans.
These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.
Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis
PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans.
NCAPG2 (zeige NCAPG2 Antikörper) plays an important role in regulating proper chromosome segregation through a functional interaction with PLK1 during mitosis
CDK-1 (zeige CDK1 Antikörper) activates PLK-1 via SPAT (zeige AGXT Antikörper)-1 phosphorylation to promote entry into mitosis.
The result provide key insights into the regulation of homolog pairing and reveal that targeting of plk-1 to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment.
SPAT (zeige AGXT Antikörper)-1 and PLK-1 depletion causes impaired polarity with abnormal length of the anterior and posterior PAR (zeige AFG3L2 Antikörper) domains, and partial plk-1(RNAi) or spat (zeige AGXT Antikörper)-1(RNAi), but not air-1(RNAi), can rescue the lethality of a par-2 (zeige F2RL1 Antikörper) mutant.
Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX (zeige ZSWIM2 Antikörper)-6.
plk-1 asymmetry contributes to asynchronous cell division in C. elegans embryos.
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis
, cell cycle regulated protein kinase
, polo (Drosophia)-like kinase
, polo like kinase
, serine/threonine-protein kinase 13
, serine/threonine-protein kinase PLK1
, polo-like kinase homolog
, polo-like protein kinase