Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human MDM4-binding Protein Antikörper:
anti-Rat (Rattus) MDM4-binding Protein Antikörper:
anti-Mouse (Murine) MDM4-binding Protein Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal MDM4-binding Protein Primary Antibody für IP, WB - ABIN151988
Patton, Mayo, Singhi, Gudkov, Stark, Jackson: Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. in Cancer research 2006
Show all 32 Pubmed References
Human Monoclonal MDM4-binding Protein Primary Antibody für ICC, IHC - ABIN969282
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 Pubmed References
Mouse (Murine) Monoclonal MDM4-binding Protein Primary Antibody für IP, ELISA - ABIN3201009
Chen, Gilkes, Pan, Lane, Chen: ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. in The EMBO journal 2005
Show all 3 Pubmed References
Human Polyclonal MDM4-binding Protein Primary Antibody für WB - ABIN2442622
Elgohary, Pellegrino, Neumann, Elzawahry, Saber, Zeeneldin, Geffers, Ehemann, Schemmer, Schirmacher, Longerich: Protumorigenic role of Timeless in hepatocellular carcinoma. in International journal of oncology 2014
Human Polyclonal MDM4-binding Protein Primary Antibody für IF, WB - ABIN517808
Jacob, OBrien, Singh, Comiskey, Littleton, Mohammad, Gladman, Widmann, Jeyaraj, Bolinger, Anderson, Barkauskas, Boris-Lawrie, Chandler: Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. in Neoplasia (New York, N.Y.) 2013
Cow (Bovine) Polyclonal MDM4-binding Protein Primary Antibody für WB - ABIN2792185
Danovi, Meulmeester, Pasini, Migliorini, Capra, Frenk, de Graaf, Francoz, Gasparini, Gobbi, Helin, Pelicci, Jochemsen, Marine: Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. in Molecular and cellular biology 2004
Show all 2 Pubmed References
Human Monoclonal MDM4-binding Protein Primary Antibody für IF, IHC - ABIN2725702
Mancini, Pieroni, Monteleone, Lucà, Fici, Luca, Urbani, Xiong, Soddu, Masetti, Lozano, Pontecorvi, Moretti: MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response. in Oncogene 2015
In multivariate analysis, MDM2 (zeige MDM2 Antikörper)/MDM4 and EGFR (zeige EGFR Antikörper) alterations correlated with time-to-treatment failure (TTF)..Some patients with MDM2 (zeige MDM2 Antikörper) family amplification or EGFR (zeige EGFR Antikörper) aberrations had poor clinical outcome and significantly increased rate of tumor growth after single-agent checkpoint (PD-1 (zeige PDCD1 Antikörper)/PD-L1 (zeige CD274 Antikörper)) inhibitors
We conclude that Mdm4-S overexpression is a consequence of splicing defects in tumor cells rather than a cause of tumor evolution.
These results indicate that the rs4245739 polymorphism may contribute to a decreased cancer susceptibility and support the hypothesis that genetic variants in the MDM4 genes act as important modifiers of cancer risk.
our study is the first to identify miR (zeige MLXIP Antikörper)-766 as a novel p53 (zeige TP53 Antikörper) activator that functions by targeting MDM4 and thereby enhancing the p53 (zeige TP53 Antikörper) signalling axis.
High MDM4 expression levels are associated with lymph node metastasis of gastric adenocarcinoma and influence the prognosis of patients with gastric adenocarcinoma
MDM4 rs4245739 A > C polymorphism appears to be associated with decreased cancer risk
analyses indicated that rs4245739 polymorphism in the MDM4 gene may play an important role in the etiology of cancer
analysis of linear and stapled peptides comprising 6-Me-tryptophan provides mechanistic insight into dual Mdm2 (zeige MDM2 Antikörper)/Mdm4 antagonism and confirms L98 of Mdm4 as a mutable steric gate. The results also highlight a possible role of the flexible hinge region in determining Mdm2 (zeige MDM2 Antikörper)/Mdm4 plasticity
we have herein demonstrated that ERalpha (zeige ESR1 Antikörper) expression associates with MDM4 and MDM2 (zeige MDM2 Antikörper) gene expression in primary breast invasive carcinoma samples
It is now clear that functional p53 (zeige TP53 Antikörper) is critical to protect the genome from alterations that lead to tumorigenesis. The current understanding of the multiple ways p53 (zeige TP53 Antikörper) contributes to genome stability and how two of its negative regulators, Mdm2 (zeige MDM2 Antikörper) and Mdmx, induce genome instability will be described. [review]
Data indicate that knockdown of the Mdm2 (zeige MDM2 Antikörper) and Mdm4 caused dramatic accumulation of mutant p53 protein (zeige TP53 Antikörper).
crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (zeige TP53 Antikörper) peptide was determined; structure reveals that although principle features of Mdm2 (zeige MDM2 Antikörper)-p53 (zeige TP53 Antikörper) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (zeige TP53 Antikörper) peptide binds is altered
Selective dysregulation of Mdm2 (zeige MDM2 Antikörper) and Mdm4 alternative splicing underlies p53 (zeige TP53 Antikörper) anti-repression and motor neuron death in a mouse model of spinal muscular atrophy.
The p53 (zeige TP53 Antikörper)-null mice with the highest level of Mdm4 tended to have multiple tumours. Mdm4 transgenic mice in various genetic backgrounds shows synergy in tumour development in vivo. Mdm4 may thus serve as a therapeutic target in cancers.
These findings suggest that Mdm2 (zeige MDM2 Antikörper) splice isoforms may play critical roles in the regulatory loop of p53 (zeige TP53 Antikörper)/Mdm2 (zeige MDM2 Antikörper)-Mdm4 via a RING domain-mediated biochemical mechanism.
both MDM2 (zeige MDM2 Antikörper) and MDMX deletion-caused pancreatic defects are completely rescued by loss of p53 (zeige TP53 Antikörper), verifying the crucial role of the MDM2 (zeige MDM2 Antikörper) and/or MDMX in regulating p53 (zeige TP53 Antikörper) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
we failed to detect any increase in p53 (zeige TP53 Antikörper) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (zeige TP53 Antikörper)-/- mice restored the fertility of females. This study is the first to show that Mdm2 (zeige MDM2 Antikörper), but not Mdm4, has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.
Data show that the Mdm4-p73 (zeige ARHGAP24 Antikörper) axis cannot override the dominant role of p53 (zeige TP53 Antikörper) in development and tumorigenesis and that Mdm4 and p73 (zeige ARHGAP24 Antikörper) interaction during development and tumorigenesis suggests new insight into the role of p53 (zeige TP53 Antikörper) family members.
MDM4/HIPK2 (zeige HIPK2 Antikörper)/p53 (zeige TP53 Antikörper) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.
MDMx degradation associated with neuronal death occurs via caspase (zeige CASP3 Antikörper) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (zeige APP Antikörper)-induced neuronal death during disease progression in AD
our results show MDM4-MDM2 (zeige MDM2 Antikörper)/p53 (zeige TP53 Antikörper)-IGF1R (zeige IGF1R Antikörper) as an original regulatory mechanism for CNS regeneration
Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
double minute 4 protein
, mdm2-like p53-binding protein
, p53-binding protein Mdm4
, protein Mdm4
, MDM4-related protein 1
, double minute 4, human homolog of; p53-binding protein
, protein Mdmx
, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
, double minute 4 homolog
, transformed mouse 3T3 cell double minute 4