anti-Cyclin B1 (CCNB1) Antikörper

Zebrafish Cyclin B1 (CCNB1) Interaktionspartner

1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Antikörper), wee1 (zeige WEE1 Antikörper), p21 (zeige CDKN1A Antikörper), PCNA (zeige PCNA Antikörper) and cdk2 (zeige CDK2 Antikörper), but only weakly influences cyclin B1, cyclin B2 (zeige CCNB2 Antikörper) and cyclin E1 (zeige CCNE1 Antikörper) expression.

2. the sequence in the coding region of cyclin B1 mRNA plays an important role as a cis (zeige CISH Antikörper)-acting element in both subcellular localization and translational timing of mRNA

3. Reporter mRNAs with the whole cyclin B1 sequence precisely mimic the localization & translation of endogenous cyclin B1 mRNA. mRNAs containing cyclin B1 3' UTR (zeige UTS2R Antikörper) but lacking ORFs had abnormal localization & precocious translational activation.

4. zebrafish cyclin B1 3'UTR (zeige UTS2R Antikörper) was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR (zeige UTS2R Antikörper) during both zebrafish and Xenopus oocyte maturation

Xenopus laevis Cyclin B1 (CCNB1) Interaktionspartner

1. Data show that CDK1 (zeige CDK1 Antikörper) and cyclin B synergize during oocyte maturation to inhibit Myt1 (zeige PKMYT1 Antikörper) ensuring meiotic progression.

2. new role for Erk (zeige MAPK1 Antikörper) in mitotic regulation, identification of the Ser (zeige SIGLEC1 Antikörper) 101-directed kinase, and a picture of cyclin B1/Cdc2 regulation by the combinatorial action of distinct kinases

3. Cyclin B1 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.

4. Cyclin B dissociation from CDK1 (zeige CDK1 Antikörper) precedes cyclins B degradation upon CDK1 (zeige CDK1 Antikörper) inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 (zeige CDK1 Antikörper) in such extracts.

5. zebrafish cyclin B1 3'UTR (zeige UTS2R Antikörper) was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR (zeige UTS2R Antikörper) during both zebrafish and Xenopus oocyte maturation

Human Cyclin B1 (CCNB1) Interaktionspartner

1. Defective cyclin B1 induction by T-DM1 (zeige DMPK Antikörper) mediates acquired resistance in HER2 (zeige ERBB2 Antikörper)-positive breast cancer cells.

2. Up-regulation of CCNB1 could be an indicator for invasiveness of pituitary adenomas.Up-regulation of CCNB1 could be an indicator for invasiveness of pituitary adenomas.

3. We identified the known APC (zeige APC Antikörper)/C regulator Cdh1 (zeige CDH1 Antikörper) and the F-box protein (zeige FBXW10 Antikörper) Fbxl15 (zeige FBXL15 Antikörper) as specific modulators of N-cyclin B1-luciferase steady-state levels and turnover. Collectively, our studies suggest that analyzing the steady-state levels of luciferase fusion proteins in parallel facilitates identification of specific regulators of protein turnover.

4. Overexpression of cyclin B1 is correlated with poor survival in most solid tumors, which suggests that the expression status of cyclin B1 is a significant prognostic parameter in solid tumors. [review]

5. CDK9 (zeige CDK9 Antikörper), in addition to CDK1 (zeige CDK1 Antikörper), has roles in mediating the growth inhibitory effect of dinaciclib on cyclin B1 in triple negative breast cancer

6. Data show that Islet-1 (ISL1 (zeige ISL1 Antikörper)) activated the expression of cyclin B1 (CCNB1), cyclin B2 (CCNB2 (zeige CCNB2 Antikörper)) and c-myc (c-MYC (zeige MYC Antikörper)) genes by binding to the conserved binding sites on their promoters or enhancers.

7. XIAP (zeige XIAP Antikörper) is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (zeige CDK1 Antikörper)-cyclin-B1 at S40.

8. ZIC5 (zeige ZIC5 Antikörper) is highly upregulated in non-small cell lung cancer tumor tissues and may act as an oncogene (zeige RAB1A Antikörper) by influencing CCNB1 and CDK1 (zeige CDK1 Antikörper) complex expression

9. Knockdown of DRG2 (zeige DRG2 Antikörper) elicited down-regulation of the major mitotic promoting factor, the cyclin B1/Cdk1 (zeige CDK1 Antikörper) complex.

10. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1 (zeige CDK1 Antikörper)) activity and mitochondrial protein (zeige COX6B2 Antikörper) synthesis in mammalian cells

Mouse (Murine) Cyclin B1 (CCNB1) Interaktionspartner

1. Results indicate that CCNB1 is critically required for the proliferation of gonocytes and spermatogonia but may be redundant in meiosis of spermatocytes in mouse spermatogenesis.

2. Results provide evidence that cdc2 (zeige CDK1 Antikörper)/cyclin B1 kinase activation was synchronous with the initial appearance of cytoskeletal lesions in mouse with Niemann-Pick disease type C.

3. Inhibition of CDK7 (zeige CDK7 Antikörper) bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.

4. timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the presence of transcripts with different 3' untranslated regions

5. AURKA (zeige AURKA Antikörper) induced phosphorylation and recruitment of CDC25B (zeige CDC25B Antikörper) to MTOCs prior to p-Cyclin B1-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.

6. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

7. Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.

8. Cyclin B1/Cdk1 (zeige CDK1 Antikörper)-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.

9. sticky siRNAs against survivin (zeige BIRC5 Antikörper) and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 (zeige F10 Antikörper) tumors as well as formation and dissemination of melanoma lung metastases.

10. Inhibitions of Aurora B (zeige AURKC Antikörper) and Cyclin-dependent kinase 1 (zeige CDK1 Antikörper) activity in vertebrate cells also have opposite effects on the timing of abscission.

Pig (Porcine) Cyclin B1 (CCNB1) Interaktionspartner

1. Cyclin B1 plays a significant role in promoting the maturation of large-follicle oocytes.

2. cyclin B1 distribution in porcine oocytes is affected by demecolcine-assisted enucleation

3. germinal vesicle is not required for the activation of M phase promoting factor during the first meiosis, but it is required for the second meiosis because of its promotion of CCNB1 accumulation

4. Results describe the expression of maternal cyclin B1 and Cdc2 (zeige CDK1 Antikörper) during in vitro maturation of porcine oocytes.

Cow (Bovine) Cyclin B1 (CCNB1) Interaktionspartner

1. Cyclin-dependent kinase (zeige CDK1 Antikörper) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (zeige MSLN Antikörper)) and MAPK (zeige MAPK1 Antikörper), and had nearly no effect on kinase activities during maturation.

2. link between cytoplasmic polyadenylation of cyclin B1 and translation/appearance of cyclin B1 protein before in vitro maturation of oocytes

3. Polyadenylation of cyclin B1 was also completely prevented when 3'-dA was added at 0 hr, and greatly reduced when added at 6 hr