anti-Cyclin B1 (CCNB1) Antikörper

Zebrafish Cyclin B1 (CCNB1) Interaktionspartner

1. The findings suggest that cyclin B1 mRNA-Staufen1 protein complexes are transported toward the animal pole of zebrafish oocytes by the plus-end-directed motor protein Kinesin1 along microtubules, and that a common mRNA transport machinery functions in zebrafish and Xenopus oocytes, although its transport direction is opposite due to different organizations of microtubules.

2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.

3. the sequence in the coding region of cyclin B1 mRNA plays an important role as a cis-acting element in both subcellular localization and translational timing of mRNA

4. Reporter mRNAs with the whole cyclin B1 sequence precisely mimic the localization & translation of endogenous cyclin B1 mRNA. mRNAs containing cyclin B1 3' UTR but lacking ORFs had abnormal localization & precocious translational activation.

5. zebrafish cyclin B1 3'UTR was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR during both zebrafish and Xenopus oocyte maturation

Xenopus laevis Cyclin B1 (CCNB1) Interaktionspartner

1. Mitotic CDK (cyclin B1-CDK1) promotes a pathway of global replisome disassembly that can trigger replication fork collapse and DNA rearrangements.

2. Data show that CDK1 and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression.

3. new role for Erk in mitotic regulation, identification of the Ser 101-directed kinase, and a picture of cyclin B1/Cdc2 regulation by the combinatorial action of distinct kinases

4. Cyclin B1 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.

5. Cyclin B dissociation from CDK1 precedes cyclins B degradation upon CDK1 inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 in such extracts.

6. zebrafish cyclin B1 3'UTR was quantitatively less effective at stimulating polyadenylation and translation compared to the Xenopus cyclin B1 3'UTR during both zebrafish and Xenopus oocyte maturation

Human Cyclin B1 (CCNB1) Interaktionspartner

1. The study provides a mechanism by which gastric tumor cells maintain their high proliferation rate via coordination of AURKB and CREPT on the expression of CCNB1.

2. Beside their direct functions in regulation of cell cycle progression, the complex of cyclin B1-CDK1 is able to coordinate the cell cycle events with enhanced mitochondrial bioenergetics. Such nucleus-mitochondria oscillation may play key roles in the flexible bioenergetics required for tumor cell survival and compromising the efficacy of anti-cancer therapy. [review]

3. This work demonstrates that in the presence of high serum, and/or Akt signaling, direct binding between Tuberin and the G2/M cyclin, Cyclin B1, is stabilized and the rate of mitotic entry is decreased.

4. Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.

5. The PFT-alpha group had increased proliferation and S-phase cell proportion and declined apoptosis, senescence, and G0/G1-phase cell proportion. CCNB1 silencing inhibits cell proliferation and promotes cell senescence via activation of the p53 signaling pathway in PC.

6. STAT3 participates in modulating G2-M phase checkpoint by regulating gene expressions of cyclin B1 and Cdc2 via E2F.

7. These findings enhance our understanding of how loss of BRCA1 disrupts mitosis regulation through dysregulation of cyclin B1 and provide evidence suggesting that targeting cyclin B1 may be useful in BRCA1-associated breast cancer therapy.

8. High expression of CCNB1 was specifically associated with poor survival in lung adenocarcinoma.

9. FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1.

10. SNAP23 suppressed progression of cervical cancer and induced cell cycle G2/M arrest via upregulating p21(cip1) and downregulating CyclinB1

11. Defective cyclin B1 induction by T-DM1 mediates acquired resistance in HER2-positive breast cancer cells.

12. Up-regulation of CCNB1 could be an indicator for invasiveness of pituitary adenomas.Up-regulation of CCNB1 could be an indicator for invasiveness of pituitary adenomas.

13. We identified the known APC/C regulator Cdh1 and the F-box protein Fbxl15 as specific modulators of N-cyclin B1-luciferase steady-state levels and turnover. Collectively, our studies suggest that analyzing the steady-state levels of luciferase fusion proteins in parallel facilitates identification of specific regulators of protein turnover.

14. Overexpression of cyclin B1 is correlated with poor survival in most solid tumors, which suggests that the expression status of cyclin B1 is a significant prognostic parameter in solid tumors. [review]

15. CDK9, in addition to CDK1, has roles in mediating the growth inhibitory effect of dinaciclib on cyclin B1 in triple negative breast cancer

16. Data show that Islet-1 (ISL1) activated the expression of cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes by binding to the conserved binding sites on their promoters or enhancers.

17. XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1-cyclin-B1 at S40.

18. ZIC5 is highly upregulated in non-small cell lung cancer tumor tissues and may act as an oncogene by influencing CCNB1 and CDK1 complex expression

19. Knockdown of DRG2 elicited down-regulation of the major mitotic promoting factor, the cyclin B1/Cdk1 complex.

20. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells

Mouse (Murine) Cyclin B1 (CCNB1) Interaktionspartner

1. Sirt1-Nrf2-Cyclin B1 signaling pathway is important for regulating oocyte meiosis and aging.

2. stress disturbed meiotic resumption through APC/C-mediated CCNB1 degradation.

3. These results have revealed a hidden compensatory mechanism between Cyclin B1 and Cyclin B2 in regulating MPF and oocyte meiotic resumption.

4. Rate of translation of Cyclin B1 and B2 proteins, together with their degradation, is a major determinant of their divergent temporal accumulation during oocyte maturation. The Cdk1-independent translation of Ccnb2 mRNA strongly suggest that this Cyclin is present in prophase and may play a critical role in setting the stockpile of Cyclin B protein for the assembly of pre-maturation promoting factor.

5. The results show that Cyclin B1 is essential for mitosis in mammalian cells and that its spatial localization has a crucial role in triggering mitosis at the correct time, even when Cdk1 can be regulated by the antagonistic Wee1-Myt1-Cdc25 pathways.

6. Results indicate that CCNB1 is critically required for the proliferation of gonocytes and spermatogonia but may be redundant in meiosis of spermatocytes in mouse spermatogenesis.

7. Results provide evidence that cdc2/cyclin B1 kinase activation was synchronous with the initial appearance of cytoskeletal lesions in mouse with Niemann-Pick disease type C.

8. Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.

9. timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the presence of transcripts with different 3' untranslated regions

10. AURKA induced phosphorylation and recruitment of CDC25B to MTOCs prior to p-Cyclin B1-Ser123, and this sequential regulation is essential for the commitment of the oocytes to resume meiosis.

11. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression

12. Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.

13. Cyclin B1/Cdk1-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.

14. sticky siRNAs against survivin and cyclin B1 efficiently blocks growth of established subcutaneaous B16-F10 tumors as well as formation and dissemination of melanoma lung metastases.

15. Inhibitions of Aurora B and Cyclin-dependent kinase 1 activity in vertebrate cells also have opposite effects on the timing of abscission.

16. It was concluded that insensitivity of mouse germinal vesicle oocytes to cyclohexidine was due to the presence of sufficient cyclin B1, and that cyclin B1 level in such oocytes was maintained by an equilibrium between synthesis and degradation.

17. Data show nuclear accumulation of cyclin B1 with a subsequent premature increase in G2/M kinase activity in Nipa-/- spermatocytes.

18. Data show that Cyclin B1 is synchronously degraded in whole oocytes and oocyte halves with a single bivalent

19. Data show that protein expression of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4 was downregulated upon LXR activation.

20. Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

Pig (Porcine) Cyclin B1 (CCNB1) Interaktionspartner

1. Cyclin B1 plays a significant role in promoting the maturation of large-follicle oocytes.

2. cyclin B1 distribution in porcine oocytes is affected by demecolcine-assisted enucleation

3. germinal vesicle is not required for the activation of M phase promoting factor during the first meiosis, but it is required for the second meiosis because of its promotion of CCNB1 accumulation

4. Results describe the expression of maternal cyclin B1 and Cdc2 during in vitro maturation of porcine oocytes.

Cow (Bovine) Cyclin B1 (CCNB1) Interaktionspartner

1. Cyclin-dependent kinase inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF) and MAPK, and had nearly no effect on kinase activities during maturation.

2. link between cytoplasmic polyadenylation of cyclin B1 and translation/appearance of cyclin B1 protein before in vitro maturation of oocytes

3. Polyadenylation of cyclin B1 was also completely prevented when 3'-dA was added at 0 hr, and greatly reduced when added at 6 hr