anti-Maus COPS5 Antikörper für Immunohistochemistry

Recommended COPS5 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
  • BcDNA.LD14392
  • BcDNA:LD14392
  • CG14884
  • CH5
  • CSN-5
  • Csn5
  • DCH5
  • Dch5
  • Dmel\\CG14884
  • JAB1
  • JAB1/CSN5
  • Jab1
  • JadBp
  • csn5
  • dch5
  • jab1/csn5
  • l(3)89Cf
  • l(3)L4032
  • l(3)M203
  • quo
  • COPS5
  • MGC76063
  • AI303502
  • CSN5
  • Mov34
  • Sgn5
  • zgc:73130
  • MOV-34
  • SGN5
  • COP9 signalosome subunit 5
  • COP9 signalosome complex subunit 5
  • COP9 signalosome subunit 5 S homeolog
  • CSN5
  • COPS5
  • cops5
  • CpipJ_CPIJ012314
  • Bm1_46585
  • VDBG_06932
  • LOAG_01443
  • csn5
  • Cops5
  • cops5.S
  • csn-5
Epitop
pSer5
13
6
4
2
2
2
2
2
2
2
2
1
1
1
Reaktivität
Maus, Ratte (Rattus), Human
121
103
65
18
7
7
7
5
4
4
3
3
3
2
1
1
1
Wirt
Kaninchen
76
54
2
Klonalität
Polyklonal
Konjugat
Dieser COPS5 Antikörper ist unkonjugiert
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
114
61
43
39
33
22
19
14
1
Optionen
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Bilder

Produktnummer ABIN3022512
$ 393.25
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
18.992775 ABIN1871963 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
18.755764 ABIN3185252 ELISA IHC WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
12.992776 ABIN6260970 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.992776 ABIN604871 IHC IHC (p) IP WB Mouse IgG2a Anmelden zum Anzeigen 8H8-5 0
12.992776 ABIN5964295 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10 ABIN2990289 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
9.992776 ABIN2706422 IHC WB Rabbit Center Anmelden zum Anzeigen Polyclonal 0
9.992776 ABIN1804054 IHC IHC (p) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 0
7 ABIN216226 IHC IHC (p) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 0
7 ABIN2421763 IHC ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
6.992776 ABIN5499242 IHC IHC (p) IP WB Mouse IgG2a Anmelden zum Anzeigen 6C3-38 0
6.992776 ABIN2469777 IP IHC WB Mouse IgG2a full length Anmelden zum Anzeigen 6C3-38 0
6.992776 ABIN2471121 IP IHC WB Mouse IgG2a full length Anmelden zum Anzeigen 8H8-5 0
6.992776 ABIN2469776 IF IP IHC WB Mouse IgG2b full length Anmelden zum Anzeigen 2A10-8 0
4 ABIN5499241 IF IHC IHC (p) IP WB Mouse IgG2b Anmelden zum Anzeigen 2A10-8 0
1 ABIN2892282 IHC IHC (p) WB Rabbit Lys191 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2882092 IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2619458 IHC IHC (p) WB Rabbit Internal Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN2894586 IHC WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1977960 IF IHC IHC (p) WB Rabbit IgG AA 175-225 Anmelden zum Anzeigen Polyclonal 0

General

Antigen COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
Epitop pSer5
(13), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Reaktivität Maus, Ratte (Rattus), Human
(121), (103), (65), (18), (7), (7), (7), (5), (4), (4), (3), (3), (3), (2), (1), (1), (1)
Wirt Kaninchen
(76), (54), (2)
Klonalität
Polyklonal
Konjugat Dieser COPS5 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(114), (61), (43), (39), (33), (22), (19), (14), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-COPS5 Antikörper

Target Details COPS5 Anwendungsinformationen Handhabung Bilder
Reinigung Affinity purification
Immunogen Recombinant protein of human COP pSer5
Isotyp IgG
Plasmids, Primers & others

Target Details COPS5

Produktdetails anti-COPS5 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung COPS5 (COPS5 Antibody Abstract)
Hintergrund The COP9 Signalosome (CSN) is a ubiquitously expressed multiprotein complex that is involved in a vast array of cellular and developmental processes, which is thought to be attributed to its control over the ubiquitin-proteasome pathway. Typically, the CSN is composed of eight highly conserved subunits (CSN1-CSN8), each of which is homologous to one of the eight subunits that form the lid of the 26S proteasome particle, suggesting that these complexes have a common evolutionary ancestor. CSN was first identified in Arabidopsis thaliana mutants with a light-grown seedling phenotype when grown in the dark. The subsequent cloning of the constitutive morphogenesis 9 (cop9) mutant from Arabidopsis thaliana was soon followed by the biochemical purification of the COP9-containing multiprotein complex. It is now widely accepted that the CSN directly interacts with cullin-RING ligase (CRL) families of ubiquitin E3 complexes, and that CSN is required for their proper function. In addition, CSN may also regulate protein homeostasis through its association with protein kinases and deubiquitinating enzymes. Collectively, these activities position the CSN as a pivotal regulator of the DNA-damage response, cell-cycle control, and gene expression. COPS5/CSN5/Jab1 (c-Jun activation domain-binding protein-1) was originally identified as a transcriptional coactivator of c-Jun and subsequently discovered to be a fifth component and integral part of the CSN. As the catalytic center of the CSN, COPS5 is able to integrate multiple functions of the CSN complex such as cell-cycle control, transcription, and DNA-damage response by regulating the activity of CRLs through deneddylation of cullins. Indeed, COPS5 harbors a Mpr1-Pad1-N-terminal (MPN) domain with an embedded Jab1/CSN5 MPN domain metalloenzyme (JAMM) motif that is essential for the CSN isopeptidase activity responsible for deneddylation of CRLs. COPS5 is an evolutionarily conserved 38 kDa protein in humans, mice, fission yeast, and plants, which suggests that it is critical to cell survival and proliferation. A role for COPS5 as a positive regulator of cellular proliferation is supported by evidence that it functionally inactivates several key tumor suppressors such as p53, RUNX3, Smad4, and p27Kip1 through altered subcellular localization, degradation, and deneddylation. These findings are underscored by the observation that COPS5 overexpression has been identified in a number of different tumor types and has been implicated in the initiation and progression of several types of cancer. Moreover, COPS5-deficient mice display an embryonically lethal phenotype highlighted by elevated expression of COPS5 targets such as p53 and p27.
Synonyms: CSN5, JAB1, MGC3149, MOV-34, SGN5
Gen-ID 10987
UniProt Q92905
Pathways Zellzyklus

Anwendungsinformationen

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Handhabung Bilder zurück nach oben
Applikations-hinweise Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze / thaw cycles
Lagerung -20 °C/-80 °C

Bilder

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (pSer5) antibody (ABIN3022512) anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (pSer5) antibody
Western Blotting (WB) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (pSer5) antibody (ABIN3022512) Western blot analysis of extracts of various cell lines, using COPS5 antibody.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (pSer5) antibody (ABIN3022512) Immunohistochemistry of paraffin-embedded rat kidney using COPS5 antibody.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (pSer5) antibody (ABIN3022512) Immunohistochemistry of paraffin-embedded human liver using COPS5 antibody.