anti-Maus COPS5 Antikörper für Immunocytochemistry

Recommended COPS5 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
  • BcDNA.LD14392
  • BcDNA:LD14392
  • CG14884
  • CH5
  • CSN-5
  • Csn5
  • DCH5
  • Dch5
  • Dmel\\CG14884
  • JAB1
  • JAB1/CSN5
  • Jab1
  • JadBp
  • csn5
  • dch5
  • jab1/csn5
  • l(3)89Cf
  • l(3)L4032
  • l(3)M203
  • quo
  • COPS5
  • MGC76063
  • AI303502
  • CSN5
  • Mov34
  • Sgn5
  • zgc:73130
  • MOV-34
  • SGN5
  • COP9 signalosome subunit 5
  • COP9 signalosome complex subunit 5
  • COP9 signalosome subunit 5 S homeolog
  • CSN5
  • COPS5
  • cops5
  • CpipJ_CPIJ012314
  • Bm1_46585
  • VDBG_06932
  • LOAG_01443
  • csn5
  • Cops5
  • cops5.S
  • csn-5
Reaktivität
Human, Maus, Ratte (Rattus)
121
103
65
18
7
7
7
5
4
4
3
3
3
2
1
1
1
Wirt
Kaninchen
76
54
2
Klonalität
Polyklonal
Konjugat
Dieser COPS5 Antikörper ist unkonjugiert
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
114
61
42
39
33
21
18
14
1
Hersteller
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Bilder

Produktnummer ABIN6260970
$ 390.77
Zzgl. Versandkosten $45.00

General

Antigen COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(121), (103), (65), (18), (7), (7), (7), (5), (4), (4), (3), (3), (3), (2), (1), (1), (1)
Wirt Kaninchen
(76), (54), (2)
Klonalität
Polyklonal
Konjugat Dieser COPS5 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(114), (61), (42), (39), (33), (21), (18), (14), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-COPS5 Antikörper

Target Details COPS5 Anwendungsinformationen Handhabung Bilder
Spezifität COPS5 Antibody detects endogenous levels of total COPS5
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Immunogen A synthesized peptide derived from human COPS5
Isotyp IgG
Plasmids, Primers & others

Target Details COPS5

Produktdetails anti-COPS5 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung COPS5 (COPS5 Antibody Abstract)
Hintergrund

Description: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Gene: COPS5

Molekulargewicht 37kDa
Gen-ID 10987
UniProt Q92905
Pathways Zellzyklus

Anwendungsinformationen

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months

Bilder

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibody (ABIN6260970) Western blot analysis of Hela whole cell lysates, using COPS5 Antibody. The lane on t...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibody (ABIN6260970) ABIN6276865 staining 293 cells by IF/ICC. The sample were fixed with PFA and permeab...
Immunohistochemistry (IHC) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) antibody (ABIN6260970) ABIN6276865 at 1/100 staining Rat lung tissue by IHC-P. The sample was formaldehyde f...